Elevation of serum stem‐cell factor in postoperative biliary atresia

Honsawek, Sittisak; Chongsrisawat, Voranush; Vejchapipat, Paisarn; Thawornsuk, Nutchanart; Tangkijvanich, Pisit; Poovorawan, Yong

doi:10.1111/j.1442-200x.2007.02476.x

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Placental derived growth factor 1 (PIGF-1) is a member of the VEGF family and pathological contributor to liver fibrosis and angiogenesis. Serum stem cell factor (SCF) was shown to be elevated in 57 BA patients compared to 30 healthy controls, and furthermore, seems to be correlated with the degree of liver injury and portal hypertension [ 39 ]. In our cohort of BA patients, the SCF levels were lower (in liver and sera) compared to other proteins in the panel and did not correlate with KPE outcome.…”

Section: Discussionmentioning

confidence: 99%

Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia

Madadi-Sanjani

Froemmel

Falk

et al. 2021

JCM

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Background: Biliary atresia (BA) is a neonatal cholangiopathy characterized by progressive destruction of the biliary system resulting in liver cirrhosis. Residual bile drainage can temporarily be achieved through Kasai portoenterostomy (KPE) and some children show long-term survival with their native liver. However, most children eventually require liver transplantation (LTX). As several growth factors (GF) and chemokines have been shown to promote fibrogenesis in the liver, we assessed whether GF are predictive for the course of disease. Material and Methods: Liver and sera samples were collected from 49 infants with BA during KPE. Levels of 13 different GF were measured by multiplex immunoassay. Patient outcomes were stratified into favorable (bilirubin < 20 µmol/L at 2-year follow-up) and unfavorable (LTX). GF levels were compared between groups by a t-test, correlation coefficients were calculated, and principal component analyses performed. Results: Twenty-two patients showed a favorable and 27 an unfavorable disease course. No relation of GF and outcome could be established. In both groups, high levels of SDF-1alpha/CXCL12 (1473.0 ± 497.5 pg/mL), FGF2 (301.2 ± 207.8 pg/mL), and VEGF-a (209.0 ± 146.4 pg/mL) levels were measured within the liver, followed (in descending order) by PDGF-bb, LIF, GM-CSF, BDNF, VEGF-d, beta-NGF, IL-7, SCF, PIGF-1, and EGF. Serum marker levels showed much higher mean variation compared to hepatic values and no correlation to the protein microenvironment in the liver. Conclusions: Our study demonstrates high amounts of GF in livers from infants with BA at KPE, but no correlation to the outcome or serum values could be established. Our data suggest that local or systemic GF levels are unsuitable for prediction of the disease course. Collectively, we conclude that in BA the degree of proliferative activity caused by GF is a dismissible factor for the further course of disease.

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Section: Discussionmentioning

confidence: 99%

Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia

Madadi-Sanjani

Froemmel

Falk

et al. 2021

JCM

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“…Disease progression leads to liver fi brosis and cirrhosis with concomitant portal hypertension and hepatic failure. Although there have been several studies focusing on the role of growth factors in BA patients including serum levels of growth factors [11,21] and cytokines [3,12,22] , the determination of COX-2 expression in biliary atresia patients has received little attention.…”

Section: Discussionmentioning

confidence: 99%

Cyclooxygenase-2 Overexpression is Associated with Clinical Outcome in Biliary Atresia

Honsawek

Klaikeaw²,

Vejchapipat³

et al. 2010

Eur J Pediatr Surg

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“…Although the etiology and pathogenesis of BA remain largely unknown, several mechanisms have been suggested including defects in biliary tract morphogenesis, defects in prenatal circulation, viral infection, exposure to environmental toxins, and immunological dysregulation [3]. A number of growth factors and cytokines have been recently documented in patients with BA including hepatocyte growth factor [4], connective tissue growth factor [5], stem-cell growth factor [6], and monocyte chemoattractant protein-1 [7].…”

Section: Introductionmentioning

confidence: 98%

Relationships between OPG, RANKL, bone metabolism, and bone mineral density in biliary atresia

et al. 2009

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Elevation of serum stem‐cell factor in postoperative biliary atresia

Cited by 6 publications

References 32 publications

Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia

Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia

Cyclooxygenase-2 Overexpression is Associated with Clinical Outcome in Biliary Atresia

Relationships between OPG, RANKL, bone metabolism, and bone mineral density in biliary atresia

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