Elevation of progesterone on the trigger day exerts no carryover effect on live birth in freeze-all cycles

Boynukalın, Fazilet Kübra; Yarkıner, Zalihe; Gültomruk, Meral; Turgut, Niyazi Emre; Ecemis, Selen; Fındıklı, Necati; Bahçeci, Mustafa

doi:10.1080/09513590.2020.1786510

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…However, the remaining six studies indicated a similar number of top-quality embryos in both groups with no obvious detrimental effect of PPE on oocyte and embryo quality. [ 42 43 44 47 54 57 ] The euploidy rate after PGT-A was also similar in most studies. [ 45 46 47 48 ]…”

Section: E Levated P Rogesterone and ...mentioning

confidence: 54%

“…Two studies[ 42 43 ] found that PPE in the fresh cycle did not hamper CLBR in subsequent FET cycles using a freeze-all approach. It was also demonstrated that in oocyte donation cycles, PPE had greater number of oocytes obtained and good quality cleavage stage embryos.…”

Section: P Remature P Rogesterone ...mentioning

confidence: 99%

“…Ten studies have been published evaluating the impact of PPE on oocyte and embryo quality since the systematic review of Venetis et al . [ 6 42 43 44 47 53 54 55 56 57 ] [ Table 2 ]. They are all retrospective cohort studies using a P threshold of 1.5–2.0 ng/ml.…”

Section: E Levated P Rogesterone and ...mentioning

confidence: 99%

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Premature progesterone elevation in in vitro fertilisation cycles – current perspectives

Gurunath

2022

J Hum Reprod Sci

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Section: E Levated P Rogesterone and ...mentioning

confidence: 54%

Section: P Remature P Rogesterone ...mentioning

confidence: 99%

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Premature progesterone elevation in in vitro fertilisation cycles – current perspectives

Gurunath

2022

J Hum Reprod Sci

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“…Moreover, there are few studies evaluating whether low P on the trigger day disrupts pregnancy outcomes or embryo quality in subsequent FET cycles. Only one study reported the effect of P<0.8 ng/ml on euploid embryos and reproductive outcomes in subsequent FET cycles ( 34 ). Nonetheless, a large-scale meta-analysis of over 55,000 cycles noted that P was significantly and inversely associated with pregnancy outcomes when the P level reached 0.8 ng/ml or above in the late-follicular phase ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of trigger-day progesterone in the preimplantation genetic testing cycle on the embryo quality and pregnancy outcomes of the subsequent first frozen-thawed blastocyst transfer

Cui²,

Shi³

et al. 2023

Front. Endocrinol.

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ObjectiveTo assess whether progesterone (P) levels on the trigger day during preimplantation genetic testing (PGT) cycles are associated with embryo quality and pregnancy outcomes in the subsequent first frozen-thawed blastocyst transfer (FET) cycle.MethodsIn this retrospective analysis, 504 eligible patients who underwent ICSI followed by frozen-thawed embryo transfer (FET) with preimplantation genetic test (PGT) between December 2014 and December 2019 were recruited. All patients adopted the same protocol, namely, the midluteal, short-acting, gonadotropin-releasing hormone agonist long protocol. The cutoff P values were 0.5 and 1.5 ng/ml when serum P was measured on the day of human chorionic gonadotropin (HCG) administration, and cycles were grouped according to P level on the day of HCG administration. Furthermore, the effect of trigger-day progesterone on embryo quality and the subsequent clinical outcome of FET in this PGT population was evaluated.ResultsIn total, 504 PGT cycles were analyzed. There was no significant difference in the number of euploid blastocysts, top-quality blastocysts, euploidy rate, or miscarriage rate among the three groups (P>0.05). The 2PN fertilization rate (80.32% vs. 80.17% vs. 79.07%) and the top-quality blastocyst rate (8.71% vs. 8.24% vs. 7.94%) showed a downward trend with increasing P, and the between-group comparisons showed no significant differences (P>0.05). The clinical pregnancy rate (41.25% vs. 64.79%; P<0.05) and live birth rate (35.00% vs. 54.93%; P<0.05) in subsequent FET cycles were substantially lower in the high-P group than in the P ≤ 0.5 ng/ml group. After adjustments were made for confounding variables, multivariate logistic regression analysis revealed that the high-P group had a lower clinical pregnancy rate (adjusted OR, 0.317; 95% CI, 0.145–0.692; P=0.004) and live birth rate (adjusted OR, 0.352; 95% CI, 0.160–0.773; P=0.009) than the low-P group in subsequent FET cycles, and the differences were significant.Conclusion(s)This study demonstrates that in the PGT population, elevated P on the trigger day may diminish the top-quality blastocyst rate (although there is no difference in the euploidy rate). Trigger-day P is an important factor influencing clinical outcomes in subsequent FET cycles.

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“…Although previous studies have reported the live birth rate of patients with late follicular phase progesterone elevation [10,11], the evidence showing its impact on frozen embryo 2 of 9 transfer (FET) cycles is quite limited [12]. Since progesterone elevation negatively affects endometrial receptivity, the freeze-all strategy is the usual alternative [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles

Huang

Wen

et al. 2022

JCM

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Late follicular phase progesterone elevation during in vitro fertilization impedes embryo implantation. It is unclear whether late follicular phase progesterone elevation still has a negative effect on cumulative live births and embryo quality when a freeze-all strategy is adopted. Data from a total of 4072 patients were reviewed. All patients used the freeze-all strategy. Multivariate regression analyses were used to assess the association of progesterone levels with both cumulative live birth and embryo quality. There was no significant difference in the cumulative live birth rate between the groups with progesterone level <1.5 ng/mL and ≥1.5 ng/mL. The progesterone level was not associated with cumulative live birth and embryo quality.

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Elevation of progesterone on the trigger day exerts no carryover effect on live birth in freeze-all cycles

Cited by 5 publications

References 34 publications

Premature progesterone elevation in in vitro fertilisation cycles – current perspectives

Premature progesterone elevation in in vitro fertilisation cycles – current perspectives

Effects of trigger-day progesterone in the preimplantation genetic testing cycle on the embryo quality and pregnancy outcomes of the subsequent first frozen-thawed blastocyst transfer

The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles

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