Elevation of Plasma Soluble T Cell Costimulatory Molecules CTLA-4, CD28 and CD80 in Children with Allergic Asthma

Ip, W. K.; Wong, Chun Kwok; Leung, Ting Fan; Lam, C. W. K.

doi:10.1159/000084612

Cited by 19 publications

(12 citation statements)

References 78 publications

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“…Subsequent to these findings, many others have reported associations between SNPs within and around the CLTA-4 region and rheumatoid arthritis [ 10 , 11 ], celiac disease [ 12 - 14 ], type I diabetes, [ 15 ], myasthenia gravis [ 16 , 17 ] and autoimmune pancreatitis [ 18 ]. At the protein level, a variety of studies have implicated elevated levels of the sCTLA-4 protein in the plasma of patients with a variety of immunologically mediated diseases including autoimmune thyroid disease [ 6 , 19 ], systemic lupus erythematosus [ 20 ] cutaneous systemic sclerosis [ 21 ], allergic asthma [ 22 , 23 ], psoriasis vulgaris [ 24 ], and autoimmune pancreatitis [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms

Berry

Tector

Oaks

2008

J Negat Results BioMed

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Background: Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an important downregulatory molecule expressed on both T and B lymphocytes. Numerous population genetics studies have documented significant associations between autoimmune diseases and single nucleotide polymorphisms (SNPs) within and around the CTLA-4 region of chromosome 2 in man. Furthermore, circulating levels of a soluble form of CTLA-4 (sCTLA-4) have been reported in a variety of autoimmune mediated diseases. Despite these findings, the relationship between levels of sCTLA-4 protein, mRNA transcript levels, and SNPs within the CTLA-4 region have not been clearly defined. In order to further clarify this relationship, we have tested four different SNPs within the CTLA-4 region among subjects whom are negative (n = 53) versus positive (n = 28) for sCTLA-4.

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Section: Introductionmentioning

confidence: 99%

Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms

Berry

Tector

Oaks

2008

J Negat Results BioMed

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“…[19, 20] Clinical investigations in autoimmune disorders and malignancies have demonstrated increased levels of circulating soluble co‐stimulatory factors. For instance, sCD28 was increased in patients with Sjögren's syndrome [19], SLE [21] and allergic asthma [22], and sCD86 was increased in SLE [21], allergic asthma [22] and leukaemia [23]. sCD80 was also increased in SLE [21] and allergic asthma [22] and in haematological malignancies [24].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, sCD28 was increased in patients with Sjögren's syndrome [19], SLE [21] and allergic asthma [22], and sCD86 was increased in SLE [21], allergic asthma [22] and leukaemia [23]. sCD80 was also increased in SLE [21] and allergic asthma [22] and in haematological malignancies [24]. Elevated levels of sCTLA‐4 were found in SLE [21], asthma [22], thyroiditis [25] and autoimmune myasthenia gravis [26].…”

Section: Introductionmentioning

confidence: 99%

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The soluble forms of CD28, CD86 and CTLA‐4 constitute possible immunological markers in patients with abdominal aortic aneurysm

Sakthivel¹,

Shively

Kakoulidou³

et al. 2007

Journal of Internal Medicine

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Objective. The T cell co-stimulatory factors CD28 and CTLA-4 and their ligands CD80 and CD86 occur as receptors on T cells and antigen-presenting cells and also in soluble forms in the circulation. We determined the levels of soluble co-stimulatory molecules in patients with abdominal aortic aneurysm (AAA) and normal individuals. We further correlated these soluble co-stimulatory molecules to other clinical parameters of importance such as age of the patient, presence of hypertension, size of the aneurysm and levels of matrix metalloproteinases-9 and C-reactive protein.Design, setting, subjects. This case-control study was designed to quantify the circulating levels of soluble co-stimulatory molecules by an in-house enzyme linked immunosorbent assay. A total of 314 subjects participated in the study including 100 patients and 214 normal controls. The statistical analysis was performed by Mann-Whitney test and Spearman's correlation rank test.Results. Our results show increased plasma levels of sCD28, sCD86 (P ¼ 0.0001) and decreased plasma levels of sCTLA-4 (P ¼ 0.0018) in the patients compared with normal individuals. The levels of these factors were not related to the age of the patient, size of aneurysm or levels of C-reactive protein in plasma. There was, however, a significant inverse relationship between the concentrations of sCTLA-4 and sCD80 with matrix metalloproteinase-9.Conclusions. We suggest that soluble co-stimulatory molecules serve as biomarkers for the estimation of immune activation in AAA patients.

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“…A series of work by our group and others has established the critical part fulfilled by STAT5 in mast cell development and survival. In particular, STAT5A appears to be more important for survival as demonstrated by dominant negative and gene KO approaches (Shelburne et al, 2003; Ikeda et al, 2005). Bone marrow devoid of STAT5A has markedly higher rates of apoptosis and lesser proliferation compared to wild type when cultured in IL-3 or SCF alone.…”

Section: Stat5 Activity Is Modulated By Fcεri In a Fyn-dependent Mannermentioning

confidence: 99%

The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling

Pullen¹,

Falanga²,

Morales³

et al. 2012

Front. Immun.

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Mast cells are central players in immune surveillance and activation, positioned at the host–environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important and still less understood area of mast cell-mediated disease. With respect to allergic disease, it is well established that IgE and its high affinity receptor FcεRI are major mediators of mast cell activation. However, IgG-mediated signals can also modulate mast cell activities. Signals elicited by IgG binding to its cognate receptors (FcγR) are the basis for autoimmune disorders such as lupus and rheumatoid arthritis. Using knowledge of IgE-mediated mast cell signaling, recent work has begun to illuminate potential overlap between FcεRI and FcγR signal transduction. Herein we review the importance of Src family kinases in FcεRI and FcγR signaling, the role of the transcription factor STAT5, and impingement of the regulatory cytokines IL-4, IL-10, and TGFβ1 upon this network.

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Elevation of Plasma Soluble T Cell Costimulatory Molecules CTLA-4, CD28 and CD80 in Children with Allergic Asthma

Cited by 19 publications

References 78 publications

Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms

Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms

The soluble forms of CD28, CD86 and CTLA‐4 constitute possible immunological markers in patients with abdominal aortic aneurysm

The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling

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