Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection

Daure, Evence; Bélanger, Myriam; Beauchamp, Guy; Lapointe, Catherine

doi:10.1016/j.rvsc.2013.09.002

Cited by 28 publications

(29 citation statements)

References 34 publications

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“…Elevated uNGAL was detected in non‐azotaemic dogs with pyuria, presumably as a result of the increased presence of neutrophils in the urinary tract (Daure et al. ). Human neutrophils produce a different molecular form of NGAL compared with the renal form (Cai et al.…”

Section: Discussionmentioning

confidence: 99%

“…; Lippi & Cervellin ; Daure et al. ). Although ELISAs that distinguish between different molecular forms of human NGAL are available, canine NGAL ELISAs are currently unable to make this discrimination (Bangert et al.…”

Section: Discussionmentioning

confidence: 99%

“…Another potential source of variation may be the fact that, in addition to the kidney, neutrophils are capable of producing NGAL (Mori & Nakao 2007;Lippi & Cervellin 2012;Smertka & Chudek 2012). Elevated uNGAL was detected in non-azotaemic dogs with pyuria, presumably as a result of the increased presence of neutrophils in the urinary tract (Daure et al 2013). Human neutrophils produce a different molecular form of NGAL compared with the renal form (Cai et al 2010;Lippi & Cervellin 2012; Daure al.…”

Section: Discussionmentioning

confidence: 99%

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Urinary neutrophil gelatinase-associated lipocalin concentration changes after acute haemorrhage and colloid-mediated reperfusion in anaesthetized dogs

Davis

Raisis

Cianciolo

et al. 2016

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Urinary neutrophil gelatinase-associated lipocalin concentration changes after acute haemorrhage and colloid-mediated reperfusion in anaesthetized dogs

Davis

Raisis

Cianciolo

et al. 2016

Veterinary Anaesthesia and Analgesia

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“…In comparison between healthy non-azotemic dogs, dogs with lower urinary tract disorder and negative urine culture and dogs with UTI, the highest level of urinary NGAL and UNCR was found in dogs with UTI. The recommendation is to perform urine culture and to consider the results when interpreting urinary NGAL values in dogs with suspected kidney injury to avoid misdiagnosis (Daure et al 2013). UNCR was increased significantly in dogs with lower urinary tract diseases compared with healthy dogs.…”

Section: Neutrophil Gelatinase-associated Lipocalinmentioning

confidence: 99%

Urinary biomarkers of renal function in dogs and cats: a review

Kovaříková¹

2015

Vet. Med.

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Kidney diseases commonly affect dogs and cats. Early diagnosis of renal impairment may be challenging even when urinalysis is used to provide additional information. Serum creatinine concentration is often used in the diagnosis, but it is a relatively insensitive marker of renal function. Particular attention is aimed at the investigation of certain molecules that may occur in urine at elevated levels as a result of glomerular or tubular dysfunction. These changes may be found before the increase of serum creatinine levels. This review article summarises reports of urine biomarkers and their utility in detecting early kidney disease in dogs and cats. Detection of multiple urinary biomarkers in diagnosis of acute kidney injury and chronic kidney disease may increase specificity and sensitivity. Early diagnosis of reduced renal functional mass allows early therapeutic interventions which may decrease morbidity and mortality. Keywords: microalbuminuria; neutrophil gelatinase-associated lipocalin; N-acetyl-β-d-glucosaminidase; gammaglutamyl transpeptidase; immunoglobulin GAbbreviations AKI = acute kidney injury; ARF = acute renal failure; CKD = chronic kidney disease; CRP = C-reactive protein; GFR = glomerular filtration rate; GGT = gamma-glutamyl transpeptidase; HMW = high molecular weight; ICU = intensive care unit; IgG = immunoglobulin G; NAG = N-acetyl-β-d-glucosaminidase; NGAL = neutrophil gelatinaseassociated lipocalin; PTH = parathormone; RBP = retinol binding protein; UAC = urinary albumin to creatinine ratio; uGGT = urinary gamma-glutamyl transpeptidase; uNAG = urinary N-acetyl-β-d-glucosaminidase; UNCR = urinary neutrophil gelatinase-associated lipocalin to creatinine ratio; UPC = urinary protein to creatinine ratio; uRBP = urinary retinol binding protein; UTI = urinary tract infection

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“…Subsequently, novel biomarkers are emerging as alternative tools in the diagnosis of UTI (6)(7)(8)(9)(10)(11)(12)(13), and as predictors of its complications such as vesico-ureteric reflux (VUR) (14)(15)(16)(17)(18) as well as renal parenchymal injury (19)(20)(21)(22). Reports also show that febrile UTI in children activate an interleukin 6 (IL-6) and interleukin 8 (IL-8) responses, thus adding the estimation of these cytokines in the diagnostic trajectory of the disease (23,24).…”

Section: Introductionmentioning

confidence: 99%

Urinary Tract Infection in Children: Diagnostic and Prognostic Utility of Biomarkers

Uwaezuoke

2017

J Compr Ped

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In the diagnostic evaluation of urinary tract infection (UTI) in children, dipstick urinalysis and urine microscopy/culture are the initial steps. Although these investigations are not without their drawbacks, urine culture remains the gold standard. Biomarkers may also be used as diagnostic tools, predictors of complications, and renal parenchymal injury. This paper aims to review the studies reporting the utility of biomarkers in the diagnosis and prognostication of UTI. Using the key words-'urinary tract infection', 'children', and 'biomarkers'-the PubMed database was searched for systematic reviews/meta-analyses and original studies, which were published within the past 25 years. Information was also gathered from relevant textbooks published within the same period. Serum procalcitonin, urine/serum interleukin 6 (IL-6) and 8 (IL-8), as well as urine neutrophil gelatinase-associated lipocalin (NGAL) are the major biomarkers of febrile UTI. In addition, procalcitonin and these cytokines are reported to be early predictors of vesicoureteric reflux (VUR) and renal parenchymal injury, while procalcitonin and IL-6 can also help to differentiate between lower UTI and upper UTI (pyelonephritis). Despite the wide range in the sensitivity and specificity of these biomarkers reported in the reviewed studies, the values are still acceptable. Some of these biomarkers may, in the future, obviate the need for invasive radiological tests, although their utility still require validation by further research. However, given the ability of imaging studies to detect structural abnormalities of the urinary tract, their use still remains relevant in the investigation of UTI despite the radiation risks associated with majority of them.

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Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection

Cited by 28 publications

References 34 publications

Urinary neutrophil gelatinase-associated lipocalin concentration changes after acute haemorrhage and colloid-mediated reperfusion in anaesthetized dogs

Urinary neutrophil gelatinase-associated lipocalin concentration changes after acute haemorrhage and colloid-mediated reperfusion in anaesthetized dogs

Urinary biomarkers of renal function in dogs and cats: a review

Urinary Tract Infection in Children: Diagnostic and Prognostic Utility of Biomarkers

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