Elevation of microRNA-214 is associated with progression of liver fibrosis in patients with biliary atresia

Yoneyama, Tomohisa; Ueno, Takayoshi; Masahata, Kazunori; Toyama, Chiyoshi; Maeda, Akira; Tazuke, Yuko; Oue, Takaharu; Miyagawa, Shuji; Okuyama, Hiroomi

doi:10.1007/s00383-021-05009-7

Cited by 7 publications

(11 citation statements)

References 36 publications

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“…The expression of microRNA214 was higher in patients with liver cirrhosis than in those without cirrhosis 32 . Research by Yoneyama et al enrolled 54 Japanese Biliary atresia (BA) patients with different fibrosis by liver biopsy, among whom the serum of 28 BA patients was also collected 33 . Results showed the expression of microRNA214 was significantly higher in BA patients with severe fibrosis (F3–F4) than in those with mild fibrosis (F0–F2) 33 .…”

Section: Micrornamentioning

confidence: 99%

“…Research by Yoneyama et al enrolled 54 Japanese Biliary atresia (BA) patients with different fibrosis by liver biopsy, among whom the serum of 28 BA patients was also collected 33 . Results showed the expression of microRNA214 was significantly higher in BA patients with severe fibrosis (F3–F4) than in those with mild fibrosis (F0–F2) 33 . ROC analysis showed the AUC of serum microRNA214 to distinguish BA patients with severe fibrosis from those with mild fibrosis was 0.805 (95%CI:0.591–0.921) 33 .…”

Section: Micrornamentioning

confidence: 99%

“…32 Research by Yoneyama et al enrolled 54 Japanese Biliary atresia (BA) patients with different fibrosis by liver biopsy, among whom the serum of 28 BA patients was also collected. 33 Results…”

Section: Microrna214mentioning

confidence: 99%

“…showed the expression of microRNA214 was significantly higher in BA patients with severe fibrosis (F3-F4) than in those with mild fibrosis (F0-F2). 33 ROC analysis showed the AUC of serum microRNA214 to distinguish BA patients with severe fibrosis from those with mild fibrosis was 0.805 (95%CI:0.591-0.921). 33 The sensitivity and specificity were 58.8% and 90.9%,respectively.…”

Section: Microrna214mentioning

confidence: 99%

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Serum non‐coding RNAs for diagnosis and stage of liver fibrosis

Liu

Hou

et al. 2022

Clinical Laboratory Analysis

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Although the liver has regeneration capacity, chronic liver injury would lead to liver fibrosis. 1 Advanced fibrosis would result in liverrelated mortality: liver failure, and hepatocellular carcinoma. 2 The diagnosis of early liver fibrosis and accurate fibrosis stage was important for the screening, diagnosis, and treatment of liver fibrosis.Liver biopsy was the gold method to examine fibrosis. However, it has several implications: inconvenience for doctors and patients, invasive method which could cause pain and bleeding, and indeterminacy due to that specimen was only a very small part of the liver. 3 Non-invasive tests for fibrosis were developed, which include radiologic and serum-based test. Radiologic examinations include ultrasonography, magnetic resonance imaging, and elastography; however, they also have some implications: obesity impact, inconvenience, and high cost. 4 Serum-based methods include serum algorithm

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Section: Micrornamentioning

confidence: 99%

Section: Micrornamentioning

confidence: 99%

Section: Microrna214mentioning

confidence: 99%

Section: Microrna214mentioning

confidence: 99%

See 2 more Smart Citations

Serum non‐coding RNAs for diagnosis and stage of liver fibrosis

Liu

Hou

et al. 2022

Clinical Laboratory Analysis

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“…Moreover, a mouse liver screening after biliary obstruction identified upregulation of miRNA let7a-5p, which targets the 3 0 -UTR and downregulates the expression of ABCC2, a gene encoding a critically important transporter involved in biliary excretion [4]. Hepatic overexpression of miR-214 was also found to be associated with progression of liver fibrosis in patients with biliary atresia [5].…”

Section: Introductionmentioning

confidence: 99%

Cholangiopathies and the noncoding revolution

Gradilone

Brunetti‐Pierri

Piccolo

2022

Current Opinion in Gastroenterology

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Purpose of reviewNoncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) among others, have attracted a great deal of attention for their potential role as master regulators of gene expression and as therapeutic targets. This review focuses on recent advances on the role of ncRNAs in the pathogenesis, diagnosis and treatment of diseases of the cholangiocytes (i.e. cholangiopathies). Recent findingsIn the recent years, there has been an exponential growth in the knowledge on ncRNAs and their role in cholangiopathies, particularly cholangiocarcinoma.

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Robotic-assisted Kasai portoenterostomy for biliary atresia

Zhang

Cao

et al. 2023

Surg Endosc

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Elevation of microRNA-214 is associated with progression of liver fibrosis in patients with biliary atresia

Cited by 7 publications

References 36 publications

Serum non‐coding RNAs for diagnosis and stage of liver fibrosis

Serum non‐coding RNAs for diagnosis and stage of liver fibrosis

Cholangiopathies and the noncoding revolution

Robotic-assisted Kasai portoenterostomy for biliary atresia

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