Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors

Calzada, M C; López-Riquelme, Natividad; Noguera, José Antonio; Mendiola, Jaime; Torres, A. Martínez

doi:10.1007/s40618-018-0888-y

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…The present study shows statistically no significantly higher serum levels of 8-Isoprostane in women with PCOS compared with controls. The present study showed no evidence that the 8-Isoprostane used to evaluate oxidative stress in association with risk factors of CVD, which is not consistent with the commonly held notion that oxidative stress significantly contributes to CVD where there were no statistically significant between 8-Isoprostane with another parameter and the results of this study were that 8-Isoprostane levels showed negative weak correlate with most parameters in patients and this was not consistent with the previous study which showed presence association between 8-Isoprostane with higher CV risk in women with polycystic ovary syndrome [7] .…”

Section: Discussioncontrasting

confidence: 99%

“…Isoprostane is a group of compounds create via encouraging of free radicals for non-enzymatic peroxidation of arachidonic acid that is similar to prostaglandins [6] . Since Isoprostane's discovery by Roberts and Morrow in 1990 [7] , proposed many studies the good biomarker reliable for endogenous lipid peroxidation is the level of Isoprostane, consequently in vivo is important tool reverse the damage and oxidative status [6] . The high concentrations of 8-Isoprostane promote atherosclerosis and cardiovascular disease.…”

Section: Annals Of Tropical Medicine and Publicmentioning

confidence: 99%

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The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

Khudhair¹,

Taha²

2020

ATMPH

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The current study emphasis assay the association of 8-Isoprostane levels with cardiovascular disease risk factors in polycystic ovary syndrome patients, which is conceder as a current endocrine metabolic disorder that uncovers many serious rates outcomes to female good health, inclusively terrible ratio of infertility. This study including a total of 90 women divided into two groups (50 PCOS patients and 40 healthy controls). Homeostasis model assessment (HOMA-IR), lipid parameters, atherogenic index of plasma (AIP) as well as anthropometric measurements were measured. The level of 8-Isoprostane in serum was measured by a commercially available ELISA kit. The level of 8-Isoprostane was no significantly higher in women with polycystic ovary syndrome (61.97±51.86 pg/mL) compared with the healthy control group (52.44±28.49 pg/mL) (p˃0.05). There were significantly higher in the mean of insulin, homeostatic model assessment for insulin resistance, triglycerides and atherogenic index of plasma in polycystic ovary syndrome patients than the control group (p˂0.05). There was no correlation between 8-Isoprostane with any parameter in patients with polycystic ovary syndrome as showed the Pearson correlation analyses. In conclusion, increased levels of serum 8-Isoprostane are not associated with elevated CV risk in women with polycystic ovary syndrome.

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Section: Discussioncontrasting

confidence: 99%

Section: Annals Of Tropical Medicine and Publicmentioning

confidence: 99%

The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

Khudhair¹,

Taha²

2020

ATMPH

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Biomarkers in polycystic ovary syndrome

Huffman,

Rezq,

Basnet

et al. 2023

Current Opinion in Physiology

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Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Zhuang

Luo

Wang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous condition that affects women of reproductive age. The association between PCOS and cardiovascular risk according to body mass index (BMI) categories is unclear.ObjectiveWe evaluated the association between cardiovascular risk according to BMI categories and PCOS in women of reproductive age.MethodsA literature search was conducted in the EMBASE, MEDLINE, Cochrane Library, and PubMed databases from their inception to 9 September, 2021. Observational cross-sectional, retrospective, and prospective controlled studies were included. The main analyses examined the relationship between cardiovascular risks (i.e., blood pressure and lipid levels) and BMI in women of reproductive age with PCOS.ResultsThirty-eight studies, with a total of 6,078 subjects, were included in this metaanalysis. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher in women of reproductive age with PCOS. Lower high-density lipoprotein (HDL)-cholesterol [SMD (95% CI): −0.21 (−0.35, −0.08), p = 0.002], higher triglycerides [SMD (95% CI): 0.38 (0.29, 0.48), p < 0.001], higher low-density lipoprotein (LDL)-cholesterol [SMD (95% CI): 0.29 (0.20, 0.39), p < 0.001], higher nonHDL-cholesterol [SMD (95% CI): 0.42 (0.31, 0.52), p < 0.001] and waist-to-hip ratio (WHR) [MD (95% CI): 0.03 (0.02, 0.04), p < 0.001] were seen in women of reproductive age with PCOS. In addition, the subgroup analysis revealed that systolic BP and HDL-cholesterol increased at BMI < 25 kg/m2 and BMI 25–30 kg/m2. Diastolic BP increased at BMI 25–30 kg/m2. Triglycerides, LDL-cholesterol, nonHDL-cholesterol, and WHR increased in all BMI categories.ConclusionsPCOS is associated with cardiovascular risk. Lipid levels and BP increased in women of reproductive age with PCOS, regardless of BMI.Systematic Review RegistrationOpen Science Framework (10.17605/OSF.IO/92NBY).

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Elevation of isoprostanes in polycystic ovary syndrome and its relationship with cardiovascular risk factors

Abstract: Patients with polycystic ovary syndrome have higher 8-isoprostanes levels and it is associated with several cardiovascular risk factors.

Cited by 4 publications

References 56 publications

The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

The association of isoprostane levels with cardiovascular disease risk factors in Iraqi women with polycystic ovary syndrome

Biomarkers in polycystic ovary syndrome

Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

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