Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies [published erratum appears in Blood 1996 Oct 1;88(7):2818]

Kersten, M.J.; Evers, LM; Dellemijn, P. L. I.; Berg, Hendrik Van den; Portegies, Peter; Hintzen, R.Q.; Lier, RA van; Borne, AE von dem; Oers, R van

doi:10.1182/blood.v87.5.1985.bloodjournal8751985

Cited by 4 publications

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“…From the findings of somatic mutations without ongoing mutation, it seemed likely that at least most of our lymphomas were derived from post-GC cells, in particular from memory cells. Consistent with this consideration, some previous studies 40,41) have shown a high level of soluble CD27, a memory cell marker, 16) in the cerebrospinal fluid of all 40) or most 41) brain lymphoma patients examined. In a few brain lymphoma cases, however, a flow cytometry study 42) failed to detect lymphoma cells positive for CD10, a GC cell marker.…”

Section: Discussionsupporting

confidence: 79%

Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

Endo

Zhang

Saito

et al. 2002

Japanese Journal of Cancer Research

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Using reverse transcription-polymerase chain reaction (RT-PCR), six primary brain lymphomas, pathologically diagnosed as diffuse large B-cell lymphoma, were examined for rearranged V H -D-J H sequences of the immunoglobulin heavy chain gene, focusing on somatic mutations and intraclonal heterogeneity. The reliability of the isolated PCR clones was confirmed by in situ hybridization (ISH) with complementarity-determining region (CDR) 3 oligonucleotide probes. Sequence analysis of the PCR clones revealed a high frequency of somatic mutation, ranging from 8.8 to 27.3% (mean 18.2%) in the V H gene segments in all the lymphomas. A significantly lower frequency of replacement (R) mutations than expected was also seen in their frameworks (FRs) in all cases. These findings suggested that the precursor cells were germinal center (GC)-related cells in these lymphomas. However, despite extensive cloning experiments, intraclonal heterogeneity was not detected in any case except for one in which it could not be ruled out. Thus, it seemed likely that all of our brain lymphomas were derived from GC-related cells and that at least most of them were from post-GC cells. Key words: Lymphoma -Brain lymphoma -B-cell lymphoma -Immunoglobulin gene -In situ hybridizationPrimary brain lymphoma usually occurs in the brain parenchyma of aged patients whose general organs show no lymphoproliferative focus.1, 2) Pathologically, most brain lymphomas belong to the category of diffuse large B-cell lymphoma.3-5) The incidence of this tumor is low, accounting for about 1-3% of all intracranial tumors.2) However, a high incidence has been noted in immunodeficient patients.2) In addition, an increased incidence in nonimmunodeficient patients has recently been reported in several countries.2) Although the clinical, pathological, and immunological characteristics of this tumor have been adequately described, [1][2][3][4][5][6][7][8] there still remain a number of unsolved problems, including the histogenesis of the neoplastic B lymphocytes.In B lymphocytes in general, immunoglobulin heavy and light chain genes are rearranged. 9,10) In the heavy chain gene, 1 each of heavy chain variable (V H ), diversity (D) and joining (J H ) gene segments are chosen and assembled, resulting in a considerable variety of rearranged V H -D-J H gene sequences among B cells. 9,10) In addition, further variability is introduced by random deletions and insertions of nucleotides at V H -D and D-J H junctions 11,12) as well as by somatic mutations in the entire V H -D-J H sequence. [13][14][15] While V H -D-J H gene rearrangements, which are associated with random nucleotide deletions and insertions at the V H -D and D-J H junctions, occur at an earlier stage of B-cell differentiation, somatic mutations in the entire V H -D-J H sequences occur at a later stage when B cells are in the germinal center (GC) microenvironment of the lymphatic tissues. [13][14][15] Using polymerase chain reaction (PCR), recent studies of B-cell lymphomas have analyzed the rearranged immunoglobul...

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Section: Discussionsupporting

confidence: 79%

Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

Endo

Zhang

Saito

et al. 2002

Japanese Journal of Cancer Research

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“…CD27, a lymphocyte-specific member of the TNF-receptor family, is a transmembrane glycoprotein expressed on T-lymphocytes as well as on normal and malignant B-lymphocytes. Kersten et al (1996) demonstrated a sensitivity of 100% and specificity of 82% for sCD27 in detection of leptomeningeal disease in acute lymphoblastic leukaemia as well as non-Hodgkin lymphoma. However, there is some concern regarding the specificity of sCD27 measurements in CNS lymphomas dealing with its increased expression on activated T and B-cells during infectious and inflammatory CNS diseases (Hintzen et al, 1991;Murase et al, 2000).…”

Section: Cerebrospinal Fluid Analysismentioning

confidence: 98%

“…However, their routine application in standard clinical practice of lymphoma diagnosis still remains to be established. A soluble form of CD27 (sCD27) has been described as a marker of CSF involvement of lymphoid malignancies including PCNSL (Kersten et al, 1996;Murase et al, 1998). CD27, a lymphocyte-specific member of the TNF-receptor family, is a transmembrane glycoprotein expressed on T-lymphocytes as well as on normal and malignant B-lymphocytes.…”

Section: Cerebrospinal Fluid Analysismentioning

confidence: 99%

Current strategies in the diagnosis of diffuse large B‐cell lymphoma of the central nervous system

Baraniskin

Deckert

Schulte-Altedorneburg

et al. 2011

Br J Haematol

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SummaryLymphomas can arise within the central nervous system (CNS) as primary CNS lymphoma (PCNSL) typically involving the brain and less often the leptomeninges, eyes, and spinal cord. In contrast to PCNSL, secondary CNS lymphoma (SCNSL) is considered to originate as quasi metastasis from systemic lymphoma spreading to the CNS. Both types of CNS lymphomas are predominantly tumours of the diffuse large B-cell type and represent aggressive diseases necessitating a rapid diagnosis. Following neuroimaging based on magnetic resonance imaging, stereotaxy and histopathological diagnosis of CNS lymphoma currently remain obligatory to plan treatment. However, progress in cytopathological, immunophenotypic, and molecular genetic analyses of the cerebrospinal fluid (CSF) has been achieved recently and potentially will facilitate lymphoma diagnosis in the future. This review describes the diagnostic procedures in patients with suspected CNS lymphomas, primarily PCNSL. In addition to a summary of the standard diagnostic work-up, an overview and discussion of current data on different techniques for evaluation of the CSF in CNS lymphoma are given.

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“…In HIV-positive patients with CNSL, Epstein-Barr virus (EBV) DNA in the CSF may be used as a diagnostic biomarker (34). In HIV-negative patients, several diagnostic biomarkers, including interleukin (IL)-10, IL-6, CXC chemokine ligand-13 (CXCL13), neopterin, β2-microglobulin (β2-MG), osteopontin, soluble CD27, specific microRNAs and cell-free DNA, have been described (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). Soluble transmembrane activator and CAML interactor, and soluble B-cell maturation antigen in the CSF have also been identified as promising novel biomarkers for the diagnosis and treatment monitoring of PCNSL (46).…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis, prognosis and treatment of primary central nervous system lymphoma in the elderly population (Review)

Liu

Yao

2021

Int J Oncol

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Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin lymphoma that is unique and different from systemic diffuse large B-cell lymphomas. The median age at diagnosis of PCNSL is 65 years and its incidence is rising rapidly in the elderly population. A total of ≥20% of all patients with PCNSL are ≥80 years old. Notably, age has been identified as an independent poor prognostic factor for PCNSL. Elderly patients have an inferior prognosis to that of younger patients and are more severely affected by iatrogenic toxicity; therefore, elderly patients represent a unique and vulnerable treatment subgroup. The present review summarized the available literature to provide an improved understanding of the epidemiology, clinical characteristics, diagnosis, prognosis and management of PCNSL in the elderly population. Notably, the incidence of PCNSL in immunocompetent elderly patients, predominantly in men, is increasing. For the diagnosis of CNSL, imaging-guided stereotactic biopsy is considered the gold standard. When stereotactic biopsy is not possible or conclusive, certain biomarkers have been described that can help establish a diagnosis. PCNSL has a very poor prognosis in the elderly, even though several prognostic scoring systems exist and several prognostic markers have been reported in patients with PCNSL. Furthermore, the treatment of elderly patients remains challenging; it is unlikely that a novel agent could be used as a curative monotherapy; however, a combination of novel agents with polychemotherapy or its combination with other novel drugs may have therapeutic potential. Contents1. Epidemiology 2. Clinical manifestation 3. Brain imaging

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Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies [published erratum appears in Blood 1996 Oct 1;88(7):2818]

Cited by 4 publications

References 0 publications

Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

Current strategies in the diagnosis of diffuse large B‐cell lymphoma of the central nervous system

Diagnosis, prognosis and treatment of primary central nervous system lymphoma in the elderly population (Review)

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