Elevation of cerebral lactate detected by localized sup 1 H-magnetic resonance spectroscopy in migraine during the interictal period

Watanabe, Hiroshi; Kuwabara, Takashi; Ohkubo, Masaki; Tsuji, Shohei; Yuasa, Takayuki

doi:10.1212/wnl.47.4.1093

Cited by 69 publications

(70 citation statements)

References 6 publications

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“…In Lodi et al, prolonged aura/ migrainous stroke) out of six investigated migraine patients (27). The migraine patient group in the study of Sandor et al was also rather heterogeneous, including patients suffering from…”

Section: Migraine Subtypes and Attack Frequencymentioning

confidence: 99%

“…According to several studies this was due to the fact that aura, with most often visual symptoms, could be attributed to this area in MwA patients (13,27,37,49). However, aura symptoms are experienced by 20-30% of migraine patients.…”

Section: Occipitalmentioning

confidence: 99%

“…three MwA patients, one basilar-type migraine patient, one migrainous stroke patient and one migraine with prolonged aura/ migrainous stroke patient) (27).…”

Section: Lacmentioning

confidence: 99%

“…Attack-free intervals ranged from 48 hours (12,27,30,31) to a few days (11,28,34,49), from a week (5-7, 10, 14) to more than a week (17,19,20,23,39). In all other studies no information concerning the attack-free period is specified (8, 9, 13, 15, 16, 18, 24, 36, 37, 45, 48, 54).…”

Section: Ictal Versus Interictalmentioning

confidence: 99%

“…In quite a few other studies, however, no information about the medication history of migraine patients is given (15,17,19,20,27,28,37,48,54). Furthermore, in the earliest MRS-studies (5-7) as well as in Prescot et al (45), a small minority of patients studied ictally were taking medication for migraine prophylaxis.…”

Section: Prophylaxis: Yes or No?mentioning

confidence: 99%

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Magnetic resonance spectroscopy in migraine: What have we learned so far?

2012

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Objective: To summarize and evaluate proton (1H) and phosphorus (31P) magnetic resonance spectroscopy (MRS) findings in migraine. Methods: A thorough review of 1H and/or 31P-MRS studies in any form of migraine published up to September 2011. Results: Some findings were consistent in all studies, such as a lack of ictal/interictal brain pH change and a disturbed energy metabolism, the latter of which is reflected in a drop in phosphocreatine content, both in the resting brain and in muscle following exercise. In a recent interictal study ATP was found to be significantly decreased in the occipital lobe of migraine with aura patients, reinforcing the concept of a mitochondrial component to the migraine threshold, at least in a subgroup of patients. In several studies a correlation between the extent of the energy disturbance and the clinical phenotype severity was apparent. Less consistent but still congruent with a disturbed energy metabolism is an observed lactate increase in the occipital cortex of several migraine subtypes (MwA, migraine with prolonged aura). No increases in brain glutamate levels were found. Conclusion: The combined abnormalities found in MRS studies imply a mitochondrial component in migraine neurobiology. This could be due to a primary mitochondrial dysfunction or be secondary to, for example, alterations in brain excitability. The extent of variation in the data can be attributed to both the variable clinical inclusion criteria used and the variation in applied methodology. Therefore it is necessary to continue to optimize MRS methodology to gain further insights, especially concerning lactate and glutamate.

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Section: Migraine Subtypes and Attack Frequencymentioning

confidence: 99%

Section: Occipitalmentioning

confidence: 99%

“…three MwA patients, one basilar-type migraine patient, one migrainous stroke patient and one migraine with prolonged aura/ migrainous stroke patient) (27).…”

Section: Lacmentioning

confidence: 99%