Elevation of CA 125 in patients with benign and malignant ascites

Bergmann, Jean‐François; Bidart, Jean‐Michel; George, Mercy; Beaugrand, Michel; Lévy, V. G.; Bohuon, C

doi:10.1002/1097-0142(19870115)59:2<213::aid-cncr2820590206>3.0.co;2-i

Cited by 134 publications

(64 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding may also support the notion that CA-125 is of mesothelial rather than tumoral origin. This is consistent with the findings in previous studies (Bergmann et al 1987;Zeimet et al 1996;Epiney et al 2000;Sjoval et al 2002;Miralles et al 2003;Uenishi et al 2003).…”

Section: Discussionsupporting

confidence: 94%

Diagnostic Usefulness of Carbohydrate Antigen-125 in Cancerous and Noncancerous Peritoneal Effusions

Kemer

Örmen

Kuralay

et al. 2005

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Carbohydrate antigen-125 (CA-125) is a tumor marker that has been used for differential diagnosis of peritoneal malignancies. The aim of the present study was to evaluate the diagnostic usefulness of simultaneous quantification of CA-125 in peritoneal fluid and serum for abdominal cancer cases and noncancer diseases. Noncancer disease group included cirrhotic patients (n = 28) and spontaneous bacterial peritonitis (SBP) patients (n = 11). Abdominal cancer group was composed of histologically diagnosed various malignancies (n = 10), such as gastric cancer. CA-125 levels were quantified by chemiluminescent enzyme immunoassay. Diagnostic usefulness tests and receiver operating characteristics (ROC) curve analysis were performed for the levels of peritoneal fluid CA-125 (pCA-125) and serum , and the ratio of pCA-125 to sCA-125 (p/sCA-125). The sCA-125 levels were significantly higher in noncancer patients than those in the cancer patients, while the pCA-125 levels showed no significant difference between the two groups. Notably, the p/sCA-125 ratio was significantly lower in the noncancer patients than that in the cancer patients. Area under the ROC curve was 0.267 for sCA-125, 0.542 for pCA-125 and 0.831 for p/sCA-125. The accepted cutoff values were the combination of values that gave the greatest diagnostic sensitivity plus specificity. Either sCA-125 or pCA-125 value gave lower diagnostic accuracy, whereas p/sCA-125 value demonstrated a significantly higher diagnostic accuracy (sensitivity-specificity pairs: 0.40-0.33 for sCA-125, 0.60-0.54 for pCA-125, and 0.80-0.72 for p/sCA-125, respectively). Hence, determination of p/sCA-125 improves the biochemical discrimination of abdominal cancerous cases from noncancerous diseases.carbohydrate antigen-125(CA-125); cirrhosis; spontaneous bacterial peritonitis; cancer; peritoneal effusion

show abstract

Section: Discussionsupporting

confidence: 94%

Diagnostic Usefulness of Carbohydrate Antigen-125 in Cancerous and Noncancerous Peritoneal Effusions

Kemer

Örmen

Kuralay

et al. 2005

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…High level of ADA (cut off value 24 U/L) gave the test sensitivity of 93% and specificity 96%. [2][3][4] The CA-125 is a tumor marker associated with ovarian carcinoma. The CA-125 is also significantly higher in tuberculous peritonitis.…”

Section: Introductionmentioning

confidence: 99%

Role of ascitic fluid adenosine deaminase (ADA) and serum CA-125 in the diagnosis of tuberculous peritonitis

Ali

Nath²,

Parvin

et al. 2015

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

show abstract

“…According to our results, there was a significant correlation between CA 125 serum levels and HF, including the correlation between this tumoral marker and BNP values. Many reports 12,14,19,36,37 have suggested that serosal fluids occurring in patients with HF are directly responsible for elevated serum CA 125 levels and that the presence of serosal fluid may stimulate the release of CA 125 rather than its cytopathological content. Recent studies have suggested that CHF may, in part, be an inflammatory disease.…”

Section: Discussionmentioning

confidence: 99%

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

et al. 2013

View full text Add to dashboard Cite

Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 AE 35.48 U/ mL, was significantly higher than that found in healthy controls (9.20 AE 4.55 U/mL; p ¼ 0.003). Patients with elevated CA 125 levels (n ¼ 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r ¼ 0.596, p50.05) and C-reactive protein (CRP) levels (r ¼ 0.439, p50.05), as well as LVEDd (r ¼ 0.599, p50.001), LVESd (r ¼ 0.750, p50.001) and LV mass index (r ¼ 0.378, p50.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r ¼ À0.513, p50.05) and hemoglobin (r ¼ À0.475, p50.05) as well as the EF (r ¼ À0.878, p50.0001). A depressed EF ( ¼ À1.121, p50.0001) and increased CRP levels ( ¼ 0.247, p ¼ 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.

show abstract

Elevation of CA 125 in patients with benign and malignant ascites

Cited by 134 publications

References 9 publications

Diagnostic Usefulness of Carbohydrate Antigen-125 in Cancerous and Noncancerous Peritoneal Effusions

Diagnostic Usefulness of Carbohydrate Antigen-125 in Cancerous and Noncancerous Peritoneal Effusions

Role of ascitic fluid adenosine deaminase (ADA) and serum CA-125 in the diagnosis of tuberculous peritonitis

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

Contact Info

Product

Resources

About