Elevation of C-reactive protein in adolescent bipolar disorder vs. anxiety disorders

Whitney, Marybeth; Scott, Stephen L.; Perez, Abe; Barnes, Stephanie; McVoy, Molly

doi:10.1016/j.jpsychires.2022.09.019

Cited by 3 publications

(2 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, maternal inflammation may play a significant role in the offspring’s schizophrenia, and increased maternal CRP has been significantly associated with the condition in their offspring [ 619 ]. Despite the fact that some studies have possibly linked CRP in Bipolar Disorder (BD) cases with underlying medical conditions or obesity, a recent study revealed that mean CRP levels were notably elevated in BD adolescents relative to those with anxiety issues and no psychiatric conditions; the mean CRP levels were lower in those with anxiety compared to those with no issues, and although CRP was significantly higher in males and younger individuals, the important between-cohort CRP differences remained after controlling for multiple confounders [ 620 , 621 , 622 , 623 ]. It was discussed that CRP concentrations play the role of biomarker to differentiate between major depressive disorder and bipolar disorder depression in both depressed and euthymic states in these individuals [ 623 ].…”

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

View full text Add to dashboard Cite

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of various diseases is presented, of all cardiovascular, respiratory, hepatobiliary, gastrointestinal, pancreatic, renal, gynecological, andrological, dental, oral, otorhinolaryngological, ophthalmological, dermatological, musculoskeletal, neurological, mental, splenic, thyroid conditions, as well as infections, autoimmune-supposed conditions and neoplasms, including other possible factors that have been linked with elevated concentrations of that protein. Moreover, data on molecular diagnostics on CRP are discussed, and possible etiologies of false test results are highlighted. Additionally, this review evaluates all current pieces of evidence on CRP and systemic inflammation, and highlights future goals. Finally, a novel diagnostic algorithm to carefully assess the CRP level for a precise diagnosis of a medical condition is illustrated.

show abstract

Section: Current Evidence On C-reactive Protein and Potential Conditionsmentioning

confidence: 99%

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Mouliou

2023

Diseases

View full text Add to dashboard Cite

show abstract

“…Meta-analyses report that levels of CRP are higher in adults with BD compared with healthy controls ( Dargel et al, 2015 ), especially during manic and depressive episodes ( Solmi et al, 2021 ). Similarly, youth with BD exhibit higher CRP levels compared with control groups (CG) or patients with other psychiatric disorders ( Zou et al, 2021 ; Whitney et al, 2022 ; Wu et al, 2022 ; Chen et al, 2023 ). In addition, higher CRP levels were also significantly associated with more severe mood symptoms in youth with BD ( Goldstein et al, 2011 ; Karthikeyan et al, 2022 ).…”

Section: Introductionmentioning

confidence: 97%

Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder

Shao,

Zou,

Kennedy

et al. 2023

International Journal of Neuropsychopharmacology

View full text Add to dashboard Cite

Background Inflammation is implicated in the neuropathology of bipolar disorder (BD). The association of C-reactive protein (CRP) with brain structure has been examined in relation to BD among adults but not youth. Methods Participants included 101 youth (BD, n=55; control group [CG], n=46; aged 13-20 years). Blood samples were assayed for levels of CRP. T1-weighted brain images were acquired to obtain cortical surface area (SA), volume, and thickness for three regions of interest (ROI; whole-brain cortical gray matter, prefrontal cortex (PFC), orbitofrontal cortex (OFC)) and for vertex-wise analyses. Analyses included CRP main-effects and interaction effects controlling for age, sex, and intracranial volume. Results In ROI analyses, higher CRP was associated with higher whole-brain SA (β=0.16; p=0.03), lower whole-brain (β=-0.31; p=0.03) and OFC cortical thickness (β=-0.29; p=0.04) within the BD group, and was associated with higher OFC SA (β=0.17; p=0.03) within CG. In vertex-wise analyses, higher CRP was associated with higher SA and lower cortical thickness in frontal and parietal regions within BD. A significant CRP-by-diagnosis interaction was found in frontal and temporal regions, whereby higher CRP was associated with lower neurostructural metrics in the BD group but higher neurostructural metrics in CG. Conclusions This study found that higher CRP among youth with BD is associated with higher SA but lower cortical thickness in ROI and vertex-wise analyses. The study identified two regions in which the association of CRP with brain structure differs between youth with BD vs. CG. Future longitudinal, repeated-measures studies incorporating additional inflammatory markers are warranted.

show abstract

Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder – A systematic review and meta-analysis

Munkholm,

Mäkinen,

Maigaard

et al. 2024

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Elevation of C-reactive protein in adolescent bipolar disorder vs. anxiety disorders

Cited by 3 publications

References 124 publications

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians

Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder

Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder – A systematic review and meta-analysis

Contact Info

Product

Resources

About