Elevation of C‐reactive protein and interleukin‐6 in plasma of patients with aggressive periodontitis

Sun, X. F.; Meng, Hua; Shi, Dong; Xu, Li; Zhang, L.; Chen, Z. B.; Feng, Xiaodong; Lu, Ruifang; Ren, Xiang

doi:10.1111/j.1600-0765.2008.01131.x

Cited by 53 publications

(53 citation statements)

References 36 publications

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“…For example, Glurich (Glurich et al 2002), reporting data from the Erie County Periodontal Epidemiology Study, noted a hierarchy in levels of CRP, serum amyloid A and alpha 1-antichymotrypsin, wherein the highest levels were found in patients with both periodontitis and CVD compared to either condition alone. Other markers such as ceruloplasmin and sVCAM-1 were elevated only in CVD Serum levels increased in chronic periodontitis (CP) Ebersole et al 1997, Loos et al 2000, Slade et al 2000, Noack et al 2001, Offenbacher 2002, Ebersole et al 2002, Buhlin et al 2003, Beck and Slade et al 2003, Amar et al 2003, Yoshii et al 2009, Gomes-Filho et al 2011, Pejcic et al 2011, Serum levels increased in aggressive periodontitis Salzberg et al 2006, Sun et al 2009, Serum levels increased in patients with CVD and CP compared to either condition alone Glurich et al 2002, Persson et al 2005, Amabile et al 2008, Malali et al 2010, Liu et al 2010 PAF levels elevated in serum and gingiva, PAF-AH levels decrease following therapy Noguchi et al 1989, Losche et al 2005, Zheng et al 2006, Chen et al 2010 while some including sICAM-1 were not elevated. Similar observations have since been made in other populations, including a Chinese population with relatively low CRP concentrations (Liu et al 2010).…”

Section: C-reactive Proteinmentioning

confidence: 99%

“…Further studies have provided evidence for elevated systemic levels of additional proinflammatory mediators and markers in chronic periodontitis (CP) including fibrinogen, haptoglobin, and IL-18, as well as decreased levels of anti-inflammatory mediators including IL-4 (Buhlin et al 2009). Furthermore, CRP levels may be elevated in sera from patients with AgP based on two studies (Salzberg et al 2006, Sun et al 2009). …”

Section: C-reactive Proteinmentioning

confidence: 99%

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Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Schenkein

Loos

2013

Journal of Periodontology

174

120

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Inflammatory mechanisms linking periodontal diseases to cardiovascular diseasesSchenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. AbstractAims: In this article, inflammatory mechanisms that link periodontal diseases to cardiovascular diseases are reviewed. Methods: This article is a literature review. Results: Studies in the literature implicate a number of possible mechanisms that could be responsible for increased inflammatory responses in atheromatous lesions due to periodontal infections. These include increased systemic levels of inflammatory mediators stimulated by bacteria and their products at sites distant from the oral cavity, elevated thrombotic and hemostatic markers that promote a prothrombotic state and inflammation, cross-reactive systemic antibodies that promote inflammation and interact with the atheroma, promotion of dyslipidemia with consequent increases in pro-inflammatory lipid classes and subclasses, and common genetic susceptibility factors present in both disease leading to increased inflammatory responses. Conclusions: Such mechanisms may be thought to act in concert to increase systemic inflammation in periodontal disease and to promote or exacerbate atherogenesis. However, proof that the increase in systemic inflammation attributable to periodontitis impacts inflammatory responses during atheroma development, thrombotic events or myocardial infarction or stroke is lacking.

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Section: C-reactive Proteinmentioning

confidence: 99%

Section: C-reactive Proteinmentioning

confidence: 99%

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Schenkein

Loos

2013

Journal of Periodontology

174

120

View full text Add to dashboard Cite

show abstract

“…[111213141516] Since both forms of periodontitis show disparity in the rate of progression, the effect of chronic and aggressive periodontitis on CRP levels seems to be an appealing area of research. Thus, the present study was undertaken to determine the relative levels of serum CRP and compare them in aggressive and chronic periodontitis patients and correlating the serum CRP levels with severity of disease.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of serum C-reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity

et al. 2014

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Objective:C-reactive protein (CRP) is an acute-phase reactant and has been proved to be a significant predictor of future cardiovascular events. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. However, most of the studies have focused on chronic periodontitis and very few studies are done in patients with aggressive periodontitis. The aim of this study was to determine and compare the relative levels of serum CRP in aggressive and chronic periodontitis patients.Materials and Methods:A total of 75 systemically healthy subjects were divided into three groups: Group I, nonperiodontitis subjects; group II, chronic generalized periodontitis patients and group III, generalized aggressive periodontitis patients. All participants were subjected to quantitative CRP analysis using enzyme-linked immunosorbent assay.Results:Mean CRP levels were significantly greater in both group II and III as compared to group I and group III having greater level than group II. Furthermore, CRP levels positively correlated with the amount of periodontal destruction as measured by probing depth and clinical attachment loss.Conclusion:The present study indicates a positive correlation between CRP and periodontal disease severity with particular concern in younger individuals that could be a possible underlying pathway in the association between periodontal disease and the observed higher risk for cardiovascular disease in periodontitis patients.

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“…Recently, accumulated evidence has demonstrated the association between periodontitis and CRP. The serum CRP is increased in systemically healthy subjects with periodontitis [46]. It was reported that subjects with periodontitis had 1.65 mg/L higher serum CRP compared with individuals without periodontitis [47].…”

Section: Effect Of Periodontal Intervention On C-reactive Proteinmentioning

confidence: 99%

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

Chen¹,

Zhang²,

Xu³

et al. 2017

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Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre-or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.

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Elevation of C‐reactive protein and interleukin‐6 in plasma of patients with aggressive periodontitis

Abstract: Patients with aggressive periodontitis have significantly elevated levels of plasma C-reactive protein and interleukin-6. These elevated inflammatory factors might potentially increase the risk for cardiovascular events and glucose dysregulation in relatively young individuals.

Cited by 53 publications

References 36 publications

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Comparative evaluation of serum C-reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

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