Elevation of c-abl-mRNA in human leukemic b lymphoblasts

Kretser, T de; Adams, Felicity; Devereux, Lisa; Garson, Margaret; Michael, Patricia; Savin, Keith W.

doi:10.1016/0145-2126(86)90005-6

“…Several surveys of mRNA expression in human leukemias have been reported [62,[72][73][74][75][76][77][78][79][80][81]. These studies involve leukemia cell lines as well as fresh leukemia cells.…”

Section: Rnamentioning

confidence: 99%

“…In these studies of relative expression of cellular oncogenes in different leukemias no major differences were noted, except for c-fos transcription detected primarily in AML M4 and M5 [79-811 and c-cis transcription, predominantly reported in patients with CML in accelerated or acute phase [78]. Concomitant presence of transcripts of different size was reported for c-myc [73,79], c-abl [77], c-sis [78] and c-fos [79]. The ratio of expression of different mRNA species was variable and was not correlated with other characteristics of the leukemia cells.…”

Section: Rnamentioning

confidence: 99%

Oncogenes and human leukemias

Butturini¹,

Gale

²

1988

The International Journal of Cell Cloning

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Abstract. Eukaryotic cells contain a family of genes termed "cellular oncogenes" or "proto-oncogenes," thought to regulate normal cell growth and development. In some circumstances, such as following transduction by retroviruses, activation of these genes causes tumors and leukemias in animals. Possible mechanisms of cellular oncogene activation include: 1) DNA point mutation, deletion or insertion, 2) gene amplification, 3) gene activation by internal rearrangement, chromosomal translocation or promoter insertion, 4) recombinative events resulting in the formation of novel chimeric genes, and others.

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“…In these studies of relative expression of cellular oncogenes in different leukemias no major differences were noted, except for c-fos transcription detected primarily in AML M4 and M5 [79-811 and c-cis transcription, predominantly reported in patients with CML in accelerated or acute phase [78]. Concomitant presence of transcripts of different size was reported for c-myc [73,79], c-abl [77], c-sis [78] and c-fos [79]. The ratio of expression of different mRNA species was variable and was not correlated with other characteristics of the leukemia cells.…”

Section: Rnamentioning

confidence: 99%

“…Several surveys of mRNA expression in human leukemias have been reported [62,[72][73][74][75][76][77][78][79][80][81]. These studies involve leukemia cell lines as well as fresh leukemia cells.…”

Section: Rnamentioning

confidence: 99%

Oncogenes in Human Leukemias

Butturini¹,

Sthivelman

²

,

Canaani

³

et al. 1987

Acta Haematol

3

0

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Eukaryotic cells contain a family of genes termed cellular oncogenes or proto-oncogenes thought to regulate normal cell growth and development. In some abnormal circumstances, such as following transduction by retroviruses, activation of these genes causes tumors and leukemias in animals. Possible mechanisms of activation of cellular oncogenes include: (1) point mutation, deletion, insertion; (2) amplification; (3) activation by internal rearrangement, chromosomal translocation or promoter insertion, and (4) recombinatorial events resulting in the formation of novel chimeric genes, and others. In this review, we consider data implicating activation of cellular oncogenes in the pathogenesis of leukemia in man. We discuss possible mechanisms whereby oncogene activation may induce leukemias as well as the potential diagnostic and therapeutic implication

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