Elevation of amniotic fluid interleukin 6 (IL-6), IL-8 and granulocyte colony stimulating factor (G-CSF) in term and preterm parturition

Saito, Shigeru; Kimura, Tadashi; Kato, Yumiko; Ishihara, Yuki; Ichijo, Motohiko

doi:10.1016/1043-4666(93)90027-3

Cited by 183 publications

(103 citation statements)

References 22 publications

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“…The results of our study are in keeping with the results of many others in that elevated AF IL-6 concentrations correlated with positive AF culture or imminent delivery [17][18][19] . The performance statistics for IL-6 were not significantly better than for AF glucose or MMP-9, however our sample size was too small to detect clinically important differences between methods.…”

Section: Discussionsupporting

confidence: 92%

Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis

Edwards

Clark

Locksmith³

et al. 2001

Infectious Diseases in Obstetrics and Gynecology

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Objective: To evaluate amniotic fluid glucose, matrix metalloproteinase (MMP)-9, interleukin (IL)-6, and IL-12 for diagnosing subclinical chorioamnionitis in women with preterm labor. Methods: Forty-four women in preterm labor at 22-35 weeks gestation with suspected subclinical chorioamnionitis underwent amniocentesis. Amniotic fluid analysis included Gram stain, culture, and determination of glucose, MMP-9, IL-6, and IL-12 concentrations. Median values of these analytes were compared using the Mann-Whitney U test. Sensitivity, specificity, and positive and negative predictive values were calculated for tests using a positive amniotic fluid culture or delivery within 24 hours as the key outcome variables. Results: Amniotic fluid concentrations of glucose, MMP-9, and IL-6 correlated closely with positive culture or delivery within 24 hours. IL-12 concentrations did not correlate with either a positive culture or delivery within 24 hours. Conclusions: Amniotic fluid glucose, MMP-9, and IL-6 reliably predict microbial invasion of the amniotic cavity or imminent delivery. IL-12 values did not correlate with amniotic fluid culture results or imminent delivery.

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Section: Discussionsupporting

confidence: 92%

Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis

Edwards

Clark

Locksmith³

et al. 2001

Infectious Diseases in Obstetrics and Gynecology

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“…Findings of elevated IL-6 in amniotic fluid in women with premature delivery have also been documented by a number of other researchers around the world (Saito, Kasahara, Kato, Ishihara, & Ichijo, 1993;Steinborn, Kuhnert, & Halberstadt, 1996).…”

Section: Cytokines and Prostaglandinmentioning

confidence: 72%

Psychological and Physiological Stress: Impact on Preterm Birth

Gennaro

Hennessy

2003

Journal of Obstetric, Gynecologic & Neonatal Nursing

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Stress increases corticotropin‐releasing hormone and may ultimately result in increased uterine contractility. Stress also increases cytokine production, which independently may lead to preterm birth or increase susceptibility to infection, thereby increasing the risk of preterm birth. Finally, stress may change health behaviors that lead to preterm birth. Research findings on the relationship between stress and preterm birth have been contradictory. In this article, the authors propose a model of the relationship between stress and preterm birth, evaluate the research on stress and pregnancy outcomes, and discuss the implications for nursing practice and research.

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“…43 In relation to birth outcomes, elevated serum, intra-amniotic, and cervical IL-8 has been associated with preterm as well as term parturition. [44][45][46][47] IL-8, a chemokine, is a potent chemoattractant implicated in endothelial dysfunction. 48 As such, IL-8 plays an important role in the development of atherosclerosis and is implicated in risk of cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

Blair

Porter

Leblebicioğlu

et al. 2015

Sleep

160

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1259Sleep and Preterm Birth-Blair et al. INTRODUCTIONIn the United States, preterm birth affects 11.5% of deliveries and is the underlying cause of more than one third of infant deaths.1 A high proportion of surviving preterm infants suffer from severe physical and cognitive consequences, potentially requiring intensive medical and/or educational support throughout the lifespan.2 The morbidity and mortality associated with preterm birth pose significant drains on the financial and emotional resources of afflicted families, and on the nation as a whole, costing more than $26 billion annually in the United States. 3Inflammation is a causal mechanism in the initiation of preterm as well as term labor. 4 Inflammatory mediators can initiate contractions, encourage cervical ripening, and cause rupture of the membranes.4,5 Via these mechanisms, inflammation induced by infection or psychological stress may trigger early parturition. 6,7Importantly, poor sleep promotes inflammation.8 For example, in a population-based cohort of more than 5,000 adults, shorter sleep duration was associated with elevations in Study Objectives: Poor sleep promotes inflammation. In turn, inflammation is a causal mechanism in term as well as preterm parturition. In the United States, a persistent racial disparity in preterm birth exists, with African Americans showing ~1.5 times greater risk. This study examined associations among sleep quality, serum proinflammatory cytokines, and length of gestation in a racially diverse sample of 138 pregnant women. Design: Observational. Measurements: Women completed the Pittsburgh Sleep Quality Index (PSQI) and other psychosocial and behavioral measures during midpregnancy. Serum levels of interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor (TNF)-α were determined by high-sensitivity assays. Birth outcomes were determined via medical record review. Results: Among African American women (n = 79), shorter gestation was predicted by poorer overall sleep (r s = −0.35, P = 0.002) as well the following PSQI subscales: subjective sleep quality (r s = −0.34, P = 0.002), sleep latency (r s = −0.27, P = 0.02), and sleep efficiency (r s = −0.27, P = 0.02). African American women with poor sleep quality (PSQI > 5) had 10.2 times the odds of preterm birth compared to those with good sleep quality. In contrast, among European American women (n = 53), gestational length was not significantly predicted by sleep quality (Ps > 0.12). Bootstrapping analyses showed that, among African Americans, IL-8 significantly mediated the association between sleep quality and length of gestation (indirect effect estimate −0.029; 95% confidence interval −0.06, −0.002). Conclusions:The data provide novel evidence that African American women exhibit greater inflammation in response to sleep disturbance than European American women and these effects correspond with length of gestation. Racial differences in susceptibility to sleep induced immune dysregulation may contribute to marked racial disparities in preterm birth.

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Elevation of amniotic fluid interleukin 6 (IL-6), IL-8 and granulocyte colony stimulating factor (G-CSF) in term and preterm parturition

Cited by 183 publications

References 22 publications

Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis

Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis

Psychological and Physiological Stress: Impact on Preterm Birth

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

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