Elevation of 8‐hydroxy‐2′‐deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis

Abstract

Superficial siderosis is a progressive disorder of the central nervous system in which chronic intrathecal bleeding leads to hemosiderin deposition in the brain and spinal cord. Although it is hypothesized that oxidative stress caused by deposited iron contributes to the pathomechanism of superficial siderosis, there is a paucity of research supporting this hypothesis. We examined the cerebrospinal fluid of three patients with superficial siderosis for the oxidative stress marker 8‐hydroxy‐2′‐deoxyguanosine. The origin of bleeding was identified in two of the three patients, who subsequently underwent surgical treatment. We detected elevated 8‐hydroxy‐2′‐deoxyguanosine levels in the cerebrospinal fluid of all three patients that remained high in two patients, even after surgical treatment. Elevated 8‐hydroxy‐2′‐deoxyguanosine levels suggest that oxidative stress is involved in the pathomechanism of superficial siderosis.

Circadian Rhythms of Oxidative Stress Markers and Melatonin Metabolite in Patients with Xeroderma Pigmentosum Group A

“…Oxidative stress originates from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the antioxidant capacities of cells and organs [ 3 ]. Oxidative stress has been confirmed to play a role in adult-onset neurodegenerative diseases, such as Alzheimer's disease [ 4 ], and we confirmed the involvement of oxidative neuronal damage in child-onset and adult neurodegenerative diseases, such as dentatorubral-pallidoluysian atrophy and superficial siderosis [ 5 , 6 ]. We clarified the accumulation of oxidative stress markers in the basal ganglia in autopsy rains in XPA and Cockayne syndrome (CS), having a genetic defect in transcription-coupled repair, which results in multiple organ impairment and various neurological disorders [ 7 ].…”