Elevated urinary cytokine levels in patients undergoing ileal neobladder replacement compared with sigmoid neobladder replacement

Nakano, Yuzo; Inoue, Takamitsu; Takenaka, Atsushi; Hara, Isao; Fujisawa, Masato

doi:10.1007/s11255-006-9071-z

Cited by 5 publications

(1 citation statement)

References 31 publications

(39 reference statements)

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“…Nakano et al found that the level of urinary pro-inflammatory interleukin-1b, interleukin-6 and interleukin-8 in IN patients was greater than in patients with SN, and this enhanced production was associated with chronic bacteriuria. 29 This signifies that the sigmoidal mucosa can better bear the burden of chronic inflammation caused by chronic urine contact.…”

Section: Discussionmentioning

confidence: 99%

Use of sigmoid colon in orthotopic neobladder reconstruction: Long‐term results

et al. 2016

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Objectives: To present our experience with a sigmoid orthotopic neobladder. Methods: We retrospectively evaluated the functional and oncological outcomes of 160 patients who underwent orthotopic neobladder reconstruction using a detubularized 20-25-cm sigmoid segment at our institution. Each patient was evaluated every 3 months the first year, every 6 months for the next 4 years and annually thereafter. Urodynamic studies of all consenting patients were carried out after 6 months, and 2, 5 and 10 years. We carried out the log-rank test, and used Cox regression models and Kaplan-Meier survival analysis. The ANOVA test was used to compare urodynamic findings over time. Results: Mean follow up was 6.8 years (range 0.65-21.7 years). Overall survival was 58.1% at 5 years, and 47.1% at 10 years. Early complications occurred in 36 patients (22.6%); late complications in 40 (25%). Stage V chronic kidney disease developed in two patients (1.3%). Complete (daytime and night-time) continence, defined as no need for pads or condom devices, was achieved by 45% of patients at 5 years, daytime continence was achieved by just 36% of patients; both were unchanged at 10 years. A significant difference emerged in maximal neobladder capacity and post-void residual values between 6 months and 2 years, and between 2 and 5 years (P < 0.01 and P = 0.03, respectively). Conclusions: Sigmoid neobladder continence and capacity significantly improve over the first 5 years, and they remain stable over the long term. Upper urinary tract function is not affected by endoluminal pressure, and the rate of metabolic imbalance is negligible.

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Section: Discussionmentioning

confidence: 99%

Use of sigmoid colon in orthotopic neobladder reconstruction: Long‐term results

et al. 2016

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Systematic review: bacterial colonisation of conduits and neobladders—when to test, watch, and treat

Adam

Ranasinghe

et al. 2019

World J Urol

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Long-term complications arising from bowel interposition in the urinary tract

Martini

Villari

Nicita

2017

International Journal of Surgery

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After radical cystectomy or pathologies affecting the ureter(s), bowel segments can be employed to restore the natural urine flow or to create an external urinary diversion. Nevertheless, the interposition of bowel segments in the urinary tract is not devoid of complications. In fact, bowel's microstructure differs from the urothelium; specifically its mucosa is aimed at reabsorption, rather than storage. The aim of this paper is to revise the pathophysiology of complications related to bowel's mucosal properties. Those are: metabolic imbalance, malabsorption of vitamins, cholelitiasis, nephrolitiasis and infections. Their entity varies according to the segment used and to its length, which reflects the surface in contact with urine. Mostly, they occur on the long-term, but metabolic imbalances might occur soon after surgery as well.

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Elevated urinary cytokine levels in patients undergoing ileal neobladder replacement compared with sigmoid neobladder replacement

Abstract: These findings suggest that chronic inflammation was more frequently observed in patients with ileal neobladder than in those with sigmoid neobladder, and that IL-6 and IL-8 were involved in persistent bacteriuria in patients with ileal and sigmoid neobladder, respectively.

Cited by 5 publications

References 31 publications

Use of sigmoid colon in orthotopic neobladder reconstruction: Long‐term results

Use of sigmoid colon in orthotopic neobladder reconstruction: Long‐term results

Systematic review: bacterial colonisation of conduits and neobladders—when to test, watch, and treat

Long-term complications arising from bowel interposition in the urinary tract

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