Elevated Unconjugated Bilirubin  in Schizophrenic Patients

Aziz, Ilhamuddin; Widaningsih, Yuyun; Natzir, Rosdiana; Tanra, Andi Jayalangkara

doi:10.20956/nmsj.v3i1.5780

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Our results are similar to the previous study done by Aziz et al,in 2018, where unconjugated mean bilirubin level was much higher in patients with Schizophrenia. Also in line with other studies that shows much higher levels of unconjugated bilirubin mean levels even on comparing them with patients in remission phase or general populations or even with other psychiatric patients (Müller et al, 1991;Bach et al 2010 ).…”

Section: Unconjugated Bilirubin and Schizophreniasupporting

confidence: 93%

Unconjugated Bilirubin as a State Marker in Patients with Schizophrenia in Acute Episode. An Egyptian Study

Mohamed,

Abd-Elsamei,

Gabry

et al. 2024

Preprint

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Background: Evidence supporting a correlation between unconjugated bilirubin and schizophrenia is considerable. Most previous studies have reported a statistically relevant link between the two variables. Aim of the Work: To assess the level of unconjugated bilirubin in patients with schizophrenia in acute episode and to analyse its correlation with the psychopathological, psychosocial and neuropsychological dimensions. Patients and Methods: A sample of 80 subjects with schizophrenia; divided into two major groups: Cases (40 patients in relapse) and Controls (40 patients in remission) were recruited. Subjects were diagnosed by DSM-IV and underwent the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Positive and Negative Syndrome Scale (PANSS), General Assessment of Function (GAF), and Trail Making Test (TMT) were used to assess severity of symptoms, social functioning, and cognitive functioning respectively. Subjects underwent a blood draw to measure serum bilirubin level. We analysed the relation and correlation of unconjugated bilirubin with the previous scales scores. Results: The study found that patients with schizophrenia had significantly higher levels of total bilirubin, and indirect bilirubin than healthy control subjects. Only one subject (with schizophrenia) had an abnormally elevated total bilirubin level (> 1.2 mg/dL). None of the subjects had a clinically abnormal direct (> 0.3 mg/dl) or indirect bilirubin level (> 1.2 mg/dL). A statistically significant positive correlation was found between PANSS total score, PANSS N score, and PANSS G score with total, direct, and indirect bilirubin levels. Linear regression analysis showed that none of the variables entered into the analysis (age, gender, smoking, BMI, Total PANSS, PANSS P, PANSS N, PANSS G, GAF, TMT-A, TMT-B, duration of psychotic disorder, duration of untreated psychosis, and antipsychotic medications) were predictive for total or indirect bilirubin levels. However, Total PANSS, PANSS N, and PANSS G were significantly predictive for direct bilirubin levels. Conclusion: Our study managed to find a statistically significant difference for total and unconjugated bilirubin mean serum levels between patients with schizophrenia and healthy individuals. However further longitudinal studies are needed to reveal the contradictory results in literature on the unconjugated bilirubin and Schizophrenia.

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Section: Unconjugated Bilirubin and Schizophreniasupporting

confidence: 93%

Unconjugated Bilirubin as a State Marker in Patients with Schizophrenia in Acute Episode. An Egyptian Study

Mohamed,

Abd-Elsamei,

Gabry

et al. 2024

Preprint

View full text Add to dashboard Cite

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Unconjugated bilirubin as a state marker in patients with schizophrenia in acute episode: an Egyptian study

Abd-Elsamei,

Gabry,

Mohamed

et al. 2024

Middle East Curr Psychiatry

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Background There is a substantial body of evidence linking unconjugated bilirubin to schizophrenia. Most of the earlier research has found a statistically significant relationship between the two factors. Aim of the work To study the level of unconjugated bilirubin in individuals with acute schizophrenia and to investigate its correlation with neuropsychological, psychopathological, and psychosocial aspects of the disorder. Patients and methods Eighty schizophrenia patients were included in the sample, they had multiple previous episodes and were in acute episodes at the time of recruitment. Forty healthy individuals were recruited for the control group. The DSM-IV was used to diagnose the subjects, and the Trail Making Test (TMT), Positive and Negative Syndrome Scale (PANSS), General Assessment of Function (GAF), and Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) were used to evaluate the subjects’ social functioning, symptom severity, and cognitive functioning. A blood sample was drawn to measure serum bilirubin level. We analyzed the relationship and correlation of unconjugated bilirubin with the previous scale scores. Results Compared to healthy control individuals, who volunteered to participate, schizophrenia patients reported significantly higher levels of both total and indirect bilirubin. One subject (with schizophrenia) had an abnormally elevated total bilirubin level (> 1.2 mg/dL). Neither the direct nor the indirect bilirubin levels (> 0.3 mg/dl or > 1.2 mg/dL) were clinically abnormal in any of the patients. PANSS total score, PANSS N score, and PANSS G score were found to have a statistically significant positive connection with levels of total, direct, and indirect bilirubin. Age, gender, smoking, BMI, Total PANSS, PANSS P, PANSS N, PANSS G, GAF, TMT-A, TMT-B, antipsychotic medication, psychotic disorder duration, and duration of untreated psychosis were not predictive of total or indirect bilirubin levels, according to linear regression analysis. However, Total PANSS, PANSS N, and PANSS G were significantly predictive for direct bilirubin levels. Conclusion A statistically significant difference in total and unconjugated bilirubin mean serum levels between schizophrenia patients and healthy individuals was found. More studies are recommended to revise the contradictory results in literature on the unconjugated bilirubin and Schizophrenia.

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Elevated Unconjugated Bilirubin in Schizophrenic Patients

Cited by 2 publications

References 10 publications

Unconjugated Bilirubin as a State Marker in Patients with Schizophrenia in Acute Episode. An Egyptian Study

Unconjugated Bilirubin as a State Marker in Patients with Schizophrenia in Acute Episode. An Egyptian Study

Unconjugated bilirubin as a state marker in patients with schizophrenia in acute episode: an Egyptian study

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