Elevated Troponin I Level on Admission Is Associated With Adverse Outcome of Primary Angioplasty in Acute Myocardial Infarction

Matetzky, Shlomo; Sharir, Tali; Domingo, Michelle; Noč, Marko; Chyu, Kuang‐Yuh; Kaul, Sanjay; Eigler, Neal; Shah, Prediman K.; Cercek, Bojan

doi:10.1161/01.cir.102.14.1611

Cited by 83 publications

(66 citation statements)

References 25 publications

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“…[1][2][3][4][5][6] However, data on troponin's effects on actual clinical care compared to CK testing alone in a heterogeneous patient population (including patients with and without acute cardiac disease presenting at different times in their illnesses with and without classic symptoms and diagnostic ECGs) are limited. In one such population, we found that combined CK and troponin I (CKTnI) testing led to more ED discharges than CK testing alone.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, troponin testing has been shown to be especially useful for stratifying patients into those who could benefit from interventions such as low-molecular weight heparin and GPIIa/IIIb inhibitors. [4][5][6][7] These were not widely available or used at the study hospital during the majority of this study, and it is possible that in settings where these are standard interventions, troponin could be shown to influence clinical care and outcomes in different or additional ways. Discharge diagnoses were made based on all clinical information available to the study's inpatient physicians and were not independently verified.…”

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confidence: 99%

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The effect of cardiac troponin testing on clinical care in a veterans population

2005

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The effect of cardiac troponin testing on clinical care in a veterans population

2005

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“…She did not have any evidence of cardiac dysrhythmias during her stay in the emergency room. Initial Troponin I (normal <0.4 ng/mL) and CK-MB (normal <7.7 ng/mL) were elevated at 7.82 ng/mL and 55.2 ng/mL, respectively [7,8]. Six hours later, Troponin I increased to 13.44 ng/mL and CK-MB to 75.7 ng/mL.…”

Section: Casementioning

confidence: 99%

Lyme disease presenting with facial palsy and myocarditis mimicking myocardial infarction

Gilson

Khalighi

Elmi

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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A 45-year-old woman presented with a sudden episode of typical chest pain, radiating to her neck. The patient denied premature coronary artery disease in the family. Initial EKG showed normal sinus rhythm with a 1 mm ST-elevation involving lead II and lead aVF and a 1 mm ST-depression in lead V1 with associated T-wave inversion. Initial Troponin I (normal <0.4 ng/mL) and CK-MB (normal <7.7 ng/mL) were elevated at 7.82 ng/mL and 55.2 ng/mL, respectively. Six hours later, Troponin I increased to 13.44 ng/mL and CK-MB to 75.7 ng/mL. The patient underwent cardiac catheterization which did not show any significant obstructive coronary artery disease. Two days later the patient developed right-sided facial palsy. Diagnosis of Lyme disease was confirmed by ELISA with positive IgM and IgG antibodies. Treatment with intravenous ceftriaxone and oral steroids was started. Eventually resolution of symptoms and, normalization of cardiac markers and EKG changes, were achieved. This is a rare case of Lyme myocarditis associated with markedly elevated Troponin I, normal left ventricle function, and an absence of conduction abnormalities. To the best of our knowledge, Lyme myocarditis mimicking acute coronary syndrome with such high levels of Troponin I and neurologic compromise has not been previously described. Lyme myocarditis may be a challenging diagnosis in endemic areas especially in patients with coronary artery disease risk factors, presenting with typical chest pain, EKG changes and positive cardiac biomarkers. Therefore, it should be considered a differential diagnosis in patients presenting with clinical symptoms suggestive of acute coronary syndrome. Abbreviations AV: Atrioventricular; CK-MB: Creatinine Kinase-MB; EKG: Electrocardiogram; ELISA: Enzyme-Linked Immunosorbent Assay; IgG: Immunoglobulin G; IgM: Immunoglobulin M

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“…Because of its prolonged release in the blood, these biomarkers are useful diagnosing sub-acute myocardial infarction [4]. Studies showed that patients with elevated admission cTnI had a significantly higher incidence of cardiac mortality and of cardiac events, i.e., death, nonfatal myocardial infarction, target-vessel revascularization [6]. …”

Section: Troponin I (Tni)mentioning

confidence: 99%

Left Ventricular Remodeling after Acute Myocardial Infarction and Biomarkers

Žaliaduonytė-Pekšienė¹,

Portacenko²

2017

J Cardiovasc Dis Diagn

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Considering to pathogenetic mechanisms of MI a few classical biomarkers have been used for diagnosis of MI or acute coronary syndrome. Lately novel markers have been identified to provide diagnostic and prognostic information and outcome of MI or acute coronary syndrome. A few novel biomarkers are overviewed in this article. A few novel biomarkers mentioned in this article showed significant relation to left ventricle remodelling and poor prognosis after myocardial infarction.

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Elevated Troponin I Level on Admission Is Associated With Adverse Outcome of Primary Angioplasty in Acute Myocardial Infarction

Abstract: In patients with ST-segment elevation AMI, an elevated cTnI on admission is associated with an increased risk of primary angioplasty failure and a more complicated clinical course.

Cited by 83 publications

References 25 publications

The effect of cardiac troponin testing on clinical care in a veterans population

The effect of cardiac troponin testing on clinical care in a veterans population

Lyme disease presenting with facial palsy and myocarditis mimicking myocardial infarction

Left Ventricular Remodeling after Acute Myocardial Infarction and Biomarkers

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