Elevated tricuspid regurgitation velocity is associated with increased adverse haematologic events during pregnancy in women with sickle cell disease

Marshall, William H.; Cleary, Erin M.; Della-Moretta, Sherraine; Li, Rui; Samuels, Philip; Desai, Payal; Rajpal, Saurabh

doi:10.1111/bjh.18160

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…There is an increased risk of PH and mortality with a raised tricuspid regurgitant jet velocity (TRV). 5 All pregnant and breastfeeding mothers should be advised to take folate and vitamin D supplementation. 6 Annual vaccination of influenza and pneumococcal vaccine should be reviewed as a part of antenatal care.…”

Section: Introductionmentioning

confidence: 99%

Fetomaternal Outcomes among Patients with Sickle Cell Disease: A Retrospective Study

Chaudhary¹,

Pitre²

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Introduction:We are presenting a study on pregnancy with sickle cell disease (SCD), which is the most common genetic disorder with high mortality and morbidity with varying severity. It is an increasing global health problem. Materials and methods: The cases were retrieved and a case-control study was done at GMERS Medical College and Hospital over a duration of 3 years from November 2019 to September 2022. General characteristics of 32 pregnancies and their fetomaternal complications were studied. A descriptive statistical analysis of the above-mentioned data was performed, and percentages were calculated. Results: Among 32 cases, 62.5% of cases were multigravida. Anemia (moderate and severe anemia) was the most common complication (71.87%). Hemolytic crisis was seen in 18.75%, and painful crises were seen in 6.25% cases, 9.37% of cases had acute chest syndrome. Complications such as urinary tract infection (UTI) were seen in 6.25%, preeclampsia in 34.37%, 56.25% had preterm deliveries, and history of miscarriage and stillbirth was seen in 34.37%. Intrauterine growth restriction (IUGR) was seen in 9.37%, neonatal death -3.12%, low birth weight -62.5%, fetal distress -12.50%, and intrauterine fetal death (IUFD) -6.25%. Maternal mortality was seen in 12.50% cases. Discussion: Because of physiological adaptations along with sickle cell crisis, maternal and fetal complications are more in SCD patients. Conclusion:The study will help understand the outcomes of pregnancy in SCD patients and will help for a better approach in treating these patients.

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Section: Introductionmentioning

confidence: 99%

Fetomaternal Outcomes among Patients with Sickle Cell Disease: A Retrospective Study

Chaudhary¹,

Pitre²

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Prediction of obstetric outcomes in sickle cell patients based on tricuspid regurgitant velocity

Lacasse,

Williams,

Ganguli

et al. 2024

Obstet Med

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Background Transthoracic echocardiography, a validated tool for risk assessment in non-pregnant population with sickle cell disease (SCD), uses tricuspid regurgitant velocity (TRV) over 2.5 m/s is an independent mortality risk factor. Its applicability in obstetrics lacks sufficient evidence. Methods In this multicenter retrospective cohort study across five tertiary centers, we aimed to validate TRV as a determinant of increased maternal and fetal risk. Data was collected on 93 women and included 21 patients with TRV of at least 2.5 m/s. The maternal primary composite outcome included occurrence of vaso-occlusive crisis, acute chest syndrome, gestational hypertension, preeclampsia, and mortality. The fetal primary composite outcome comprised perinatal mortality, premature delivery, reduced birth weight, and fetal distress. Results Adverse maternal and fetal events arose in both groups with no statistical difference. Conclusion This study cannot support TRV of 2.5 m/s or more as an independent predictor of adverse obstetric outcomes among women with SCD.

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Elevated tricuspid regurgitation velocity is associated with increased adverse haematologic events during pregnancy in women with sickle cell disease

Cited by 2 publications

References 11 publications

Fetomaternal Outcomes among Patients with Sickle Cell Disease: A Retrospective Study

Fetomaternal Outcomes among Patients with Sickle Cell Disease: A Retrospective Study

Prediction of obstetric outcomes in sickle cell patients based on tricuspid regurgitant velocity

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