Elevated titers of cell-free interleukin-2 receptor in serum and cerebrospinal fluid specimens of patients with acquired immunodeficiency syndrome

Sethi, K. K.; Näher, Helmut

doi:10.1016/0165-2478(86)90052-0

Cited by 41 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the mentioned reports as well as our results of the high specificity for disease activity, it should be mentioned that various infectious processes can also cause elevated sCD25 levels (15,29).…”

Section: Discussioncontrasting

confidence: 39%

Serum levels of soluble forms of T cell activation antigens CD27 and CD25 in systemic lupus erythematosus in relation with lymphocytes count and disease course

et al. 1995

View full text Add to dashboard Cite

SummarySystemic lupus erythematosus (SLE) patients are characterized by a low lymphocyte count, which is considered a specific disease marker and is related to disease activity. The membrane bound molecules CD25 and CD27 are expressed and released in a soluble CD25 (sCD25) and soluble CD27 (sCD27) form by activation of predominantly T cells. In previous studies it was claimed that sCD25 as well sCD27 might be used as parameters for activation of the immune system; a correlation between the sCD25 profile with the disease course in SLE patients was also shown. To assess the relationship between lymphocyte count and these T cell activation markers, we performed a cross-sectional and a longitudinal study. In the longitudinal study three SLE patients who were known for a long time at our outpatient clinic were studied. Both T cell markers strongly correlated with each other and formed a reflection of the disease course. In all 7 periods of exacerbation, which we observed in the 3 investigated patients, both levels increased preceding this period; however, no correlation was found with the lymphocyte count. In the cross sectional study of 69 patients with SLE, sCD25 and sCD27 levels were correlated with defined disease manifestations; sCD25 was elevated in all periods of increased disease activity. The same holds true for sCD27, with the exception of patients with nephritis in which the highest levels were observed. Both profiles of sCD25 and sCD27 were strongly correlated during the whole disease course. Our data prove that in the pathogenesis of SLE an active recruitement of unprimed and primed T cells takes place.

show abstract

Section: Discussioncontrasting

confidence: 39%

Serum levels of soluble forms of T cell activation antigens CD27 and CD25 in systemic lupus erythematosus in relation with lymphocytes count and disease course

et al. 1995

View full text Add to dashboard Cite

show abstract

“…Upon stimulation, activation markers CD80, CD86 and CD70 are increased in HIV infected patients (Wolthers et al, 1996). Other soluble activation markers have also been found in serum and plasma to be increased in HIV infected patients including beta 2 -microglobulin (Grieco et al, 1984), IL-2 receptor (Sethi & Näher, 1986;Pizzolo et al, 1987), tumor necrosis factor (Reddy, Sorrell, Lange, & Grieco, 1988) tumor necrosis factor receptor II (Fahey et al, 1998) and others. A recurrent trend in research focusing on immune activation is the consistent importance of CD38 as a marker of disease prognosis.…”

Section: Immune Activation 31 Immune Activation Markers and Their Romentioning

confidence: 99%

“…Soluble markers of immune activation, that are more easily measurable than cellular activation, have also been shown to have prognostic value and predict HIV disease progression with comparable efficiency to CD4 counts and viral load measurements (Liu et al, 1997). In particular, neopterin, produced by macrophages upon IFNg stimulation (Melmed, Taylor, Detels, Bozorgmehri, & Fahey, 1989), beta 2 -microglobulin for general lymphoid activation (Chitra, Bakthavatsalam, & Palvannan, 2011;Fahey et al, 1990), and soluble IL-2 receptor (Sethi & Näher, 1986) have all been shown to be elevated and predictive of disease progression to varying degrees (Fahey et al, 1998). Increased soluble CD14 levels, a marker of monocyte activation that also correlated with IL-6, C-reactive protein, serum amyloid A and D-dimer, independently predicts mortality in HIV patients (Sandler et al, 2011).…”

Section: Immune Activation 31 Immune Activation Markers and Their Romentioning

confidence: 99%

HIV Without AIDS: The Immunological Secrets of Natural Hosts

Ende¹,

Bonkosky²,

Paiardini³

2011

HIV and AIDS - Updates on Biology, Immunology, Epidemiology and Treatment Strategies

View full text Add to dashboard Cite

“…The mechanism responsible for these reduced responses is not well understood, although both quantitative factors (related to the loss of CD4 lymphocytes) and qualitative factors (related to the function of the remaining CD4 lympho- ytes) have been implicated. Reported to be among the latter are T cell inhibitory factors present in serum from HIV+ individuals [11,12]; inhibitory effects of HIV proteins such as gpl20, gp41, and tat [13][14][15]; elevated serum levels of soluble IL-2Ra [16] which can compete with cellular IL-2R for free IL-2 [17]; reduced production of IL-2 and other growth factors [5,6,[17][18][19][20]; and overproduction of inhibitory factors such as transforming growth factor-beta 1 (TGE-jSl) [21]. A direct viral effect seems unlikely, since the frequency of HIV-infected cells is very low (10-3-10-") [22,23].…”

Section: Introductionmentioning

confidence: 99%

Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men

Chopra

Raj

Scally

et al. 1993

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYPrevious sttidies have shown that exogenous IL-2 does not correct the reduction in phytohaemagglutinin (PHA)-induced proliferation of lymphocytes from HIV-1 infected (HIV+) individuals. We investigated the mechanism of this reduction to determine if reduced expression of the complete IL-2 receptor (IL-2R) was responsible. In a series of experiments, PH A-stimulated lymphocytes from a total of 89 HIV-and 93 HIV+ homosexual men from the Baltimore Multicentre AIDS Cohort Study (MACS) were studied to determine the expression of messages for the a and ^ subunits of the IL-2R, the binding of'^5I-IL-2 to high affinity IL-2R, and the effect of IL-2 on cell proliferation. Compared to HIV" donors, PHA-stimulated lymphocytes from most HIV+ donors demonstrated (i) a reduction in high affinity IL-2R expression that correlated with the reduction in the IL-2-induced proliferative response; and (ii) a reduction in expression of both IL-2R a-and jS-chain mRNA which may be responsible for decreased high affitiity IL-2R expression. However, lymphocytes from some HIV+ individuals had borderline low IL-2-induced proliferation despite normal or elevated expression of high affinity IL-2R. These results suggest that decreased expression of IL-2R may account, at least in part, for the lower proliferative response of cells from HIV+ donors.

show abstract

Elevated titers of cell-free interleukin-2 receptor in serum and cerebrospinal fluid specimens of patients with acquired immunodeficiency syndrome

Cited by 41 publications

References 15 publications

Serum levels of soluble forms of T cell activation antigens CD27 and CD25 in systemic lupus erythematosus in relation with lymphocytes count and disease course

Serum levels of soluble forms of T cell activation antigens CD27 and CD25 in systemic lupus erythematosus in relation with lymphocytes count and disease course

HIV Without AIDS: The Immunological Secrets of Natural Hosts

Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men

Contact Info

Product

Resources

About