Elevated thalamic and prefrontal regional cerebral blood flow in obsessive–compulsive disorder: a SPECT study

Lacerda, Acioly L.T.; Dalgalarrondo, Paulo; Caetano, Dorgival; Camargo, Edwaldo E.; Etchebehere, Elba; Soares, Jair C.

doi:10.1016/s0925-4927(03)00061-1

Cited by 93 publications

(55 citation statements)

References 39 publications

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“…As an important part of the CSTC circuitry and a sensory and motor gateway, the thalamus provides specific channels from the basal ganglia to the cortical motor areas, and is responsible for sensory inputs and interactions between the cortex and basal ganglia, thus permitting the thalamus to mediate cognition and behavior [39,40]. The decreased interhemispheric VMHC values in the thalamus found in the present study indicate a reduced functional strength between the left and right sides of the thalamus.…”

Section: Research Ping LImentioning

confidence: 47%

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Wang¹,

Chen²,

Li³

et al. 2018

Neuropsychiatry

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Neuroimaging studies have shown structural and functional abnormalities in parts of the cortico-striato-thalamo-cortical (CSTC) brain circuitry in patients with obsessive-compulsive disorder (OCD). However, little is known about changes in the interhemispheric functional homotopy in the resting-state in OCD. This study used a voxel-mirrored homotopic connectivity (VMHC) approach combined with resting-state functional magnetic resonance imaging to investigate changes in interhemispheric functional homotopy in 60 OCD patients and 60 healthy controls. Compared with the healthy controls, the OCD patients showed decreased VMHC values in the thalamus. The results suggest that changes in functional homotopy in the CSTC circuitry may be involved in the pathophysiologic mechanism of OCD. Our findings provide new evidence of abnormalities in the CSTC circuitry in OCD.

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Section: Research Ping LImentioning

confidence: 47%

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Wang¹,

Chen²,

Li³

et al. 2018

Neuropsychiatry

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“…Positron emission tomography with FDG showed increased metabolic rates in the orbitofrontal and cingulate gyrus region in patients with OCD [1][2][3][4] . SPECT studies have supported these patient hyperactivity findings in some [5,6] but not all studies [7,8] . The effect was more marked in more ventral areas than dorsal areas in one study that presented this dimension [9] and more marked in medial frontal cortex in one study [10] .…”

Section: Introductionmentioning

confidence: 88%

“…SPECT studies, consistent with FDG-PET studies, also found low flow in the caudate [15][16][17] as did some fMRI studies [18] . SPECT studies found both reduced [17] and high flow [6] in the thalamus, however. Lastly, event-related brain potential measures of components associated with the anterior cingulate [19] and frontostriatal systems [20,21] have had enhanced amplitudes in OCD patients and subjects with obsessive-compulsive characteristics.…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography Imaging of Risperidone Augmentation in Serotonin Reuptake Inhibitor-Refractory Patients

Buchsbaum¹,

Hollander²,

Pallanti³

et al. 2006

Neuropsychobiology

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We studied 15 nondepressed patients with obsessive-compulsive disorder (OCD) who were nonresponders to serotonin reuptake inhibitors with an additive trial of risperidone. Positron emission tomography with ¹⁸F-deoxyglucose and magnetic resonance imaging was obtained at baseline and following 8 weeks of either risperidone or placebo in a double-blind parallel group design. Risperidone treatment was associated with significant increases in relative metabolic rate in the striatum, cingulate gyrus, the prefrontal cortex, especially in the orbital region, and the thalamus. Four of 9 patients who received risperidone showed clinical improvement (CGI score of 1 or 2 at 8 weeks) while none of the 6 patients who received placebo showed improvement. Patients with low relative metabolic rates in the striatum and high relative metabolic rates in the anterior cingulate gyrus were more likely to show a clinical response. These metabolic predictors of clinical response are consistent with earlier PET studies showing similar prediction when either neuroleptics or serotonin reuptake inhibitor treatments are administered individually. Our results are consistent with a frontostriatal circuit change related to both dopaminergic and serotonergic systems and with the presence of psychopharmacological subtypes within OCD.

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“…Interestingly in the recent report [26] right thalamic activity negatively correlated with perseverative errors in early dementia. Inverse correlation between compulsive behavior and right thalamus rCBF in obsessivecompulsive disorder was reported by Lacerda et al [27]. Weinberger postulated that primary defect in schizophrenia when performing WCST is not located in prefrontal region but in the functional connectivity, including temporal cortex [28].…”

Section: Discussionmentioning

confidence: 77%

99mTc-ECD SPECT at rest and activation in young patients with schizophrenia

et al. 2011

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AbstractThe aim of the study was to localize brain parts involved in executive functions in patients with schizophrenia by means of 99mTc-ECD single photon emission computed tomography (SPECT) with 3-dimensional automatic software. We examined 12 men with schizophrenia (mean age 29±3.9 years). Brain perfusion SPECT was performed at rest and during Wisconsin Card Sorting Test (WCST). Two types of quantitative SPECT analysis were applied; voxel-based and volume of interest (VOI)-based. With voxel-based approach, rest and activation SPECT were compared. VOI-based analysis allowed for correlation of regional cerebral blood flow (rCBF) in 20 VOIs with WCST scores. In voxel-based analysis, the patterns of rCBF decrease and increase after activation varied between patients, with combinations of different brain regions involved. In VOI-based approach, the only statistically significant difference between activation and rest was rCBF decrease in the left basal ganglia (p=0.028). The thalami and right temporal cortex correlated with the greatest number of WCST scores, followed by left occipital cortex and left cerebellum. In conclusion, our results suggest that patterns of WCST activation and deactivation vary between patients with schizophrenia. Among the network of involved brain structures, right temporal cortex and thalami appear to play the major role.

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Elevated thalamic and prefrontal regional cerebral blood flow in obsessive–compulsive disorder: a SPECT study

Cited by 93 publications

References 39 publications

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Positron Emission Tomography Imaging of Risperidone Augmentation in Serotonin Reuptake Inhibitor-Refractory Patients

99mTc-ECD SPECT at rest and activation in young patients with schizophrenia

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