Elevated Tear Interleukin-6 and Interleukin-8 Levels in Patients With Conjunctivochalasis

Erdogan-Poyraz, Ceren; Mocan, Mehmet Cem; Bozkurt, Banu; Gariboglu, S.; İrkeç, Murat; Orhan, Mehmet

doi:10.1097/ico.0b013e3181861d0c

Cited by 38 publications

(10 citation statements)

References 19 publications

(31 reference statements)

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“…Furthermore, given an association between Cch and inflammation, anti-inflammatory medications are also recommended and similarly have been shown to improve dry eye signs and symptoms in patients who suffer from dry eye syndrome. 5,[20][21][22] Finally, removal of redundant conjunctival folds, either with surgical or nonsurgical techniques (such as thermal cauterization or electrocoagulation) can improve symptoms and tear film stability. [23][24][25][26][27] As with all studies, our findings must be considered along with the limitations of this study.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Conjunctivochalasis on Dry Eye Symptoms and Signs

Chhadva

Alexander

McClellan³

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

The Impact of Conjunctivochalasis on Dry Eye Symptoms and Signs

Chhadva

Alexander

McClellan³

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…They found that some apopitosis regulation proteins, apopitosis related proteins, and inflammatory proteins are in the CCh but not in normal controls. Erdogan-Poyraz et al17 reported that inflammatory cytokine interleukin (IL)-6 and IL-8 levels were correlated with the severity of CCh. Guo et al18 found that pentraxin 3 immunostaining was strongly positive in the subconjunctival stroma of CCh specimens.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of patients with conjunctivochalasis

Balcı¹

2014

OPTH

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PurposeTo evaluate the clinical characteristics of patients with conjunctivochalasis (CCh).Methods and materialsThis retrospective study enrolled 30 subjects diagnosed with conjunctivochalasis. Complete ophthalmic examination, including visual acuity assessment, slit-lamp examination, applanation tonometry, dilated funduscopy, tear break-up time, Schirmer 1 test, and fluorescein staining were performed in all patients. Age, sex, laterality, ocular history, symptoms, and clinical findings were recorded.ResultsThe study included 50 eyes from 30 cases. Ages ranged from 45 to 80 years, with a mean age of 65±10 years. CChs grading were as follows: 30 (60%) eyes with grade 1 CCh; 15 (30%) eyes with grade 2 CCh; and five (10%) eyes with grade 3 CCh. CCh was located in the inferior bulbar conjunctiva in 45 (90%) eyes, and in the remaining five (10%) CCh was located in the superior bulbar conjunctiva. Ten (33.3%) patients had no symptoms. Dryness, eye pain, redness, blurry vision, tired eye feeling, and epiphora were the symptoms encountered in the remaining twenty (63.6%) patients. Altered tear meniscus was noted in all cases. The mean tear break-up time was 7.6 seconds. The mean Schirmer 1 test score was 7 mm. Pinguecula was found in ten patients.ConclusionDryness, eye pain, redness, blurry vision, and epiphora were the main symptoms in patients with CCh. Dryness, eye pain, and blurry vision were worsened during downgaze and blinking. So CCh should be taken into consideration in the differential diagnosis of chronic ocular irritation and epiphora.

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“…[1][2][3] Although initially asymptomatic, CCh eventually leads to dryness, tearing, subconjunctival hemorrhage, and exposure [2][3][4] Tear levels of proinflammatory cytokines such as tumor necrosis factor-␣ (TNF-␣), interleukin 1-␤ (IL-1␤), IL-6, and IL-8 are elevated in CCh patients. [5][6][7] The coexisting ocular surface inflammation might further be aggravated by delayed tear clearance, which is also frequently associated with CCh. 8 -10 We have long speculated that excessive proteolytic degradation by matrix metalloproteinases (MMPs) leads to CCh.…”

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confidence: 99%