Elevated Syndecan-1 levels in the sera of patients with breast cancer correlate with tumor size

Malek-Hosseini, Zahra; Jelodar, Sina; Talei, Abdolrasoul; Ghaderi, Abbas; Doroudchi, Mehrnoosh

doi:10.1007/s12282-017-0773-0

Cited by 19 publications

(16 citation statements)

References 34 publications

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“…The altered expression profiles of ECM components, such as integrins, cadherins, and syndecans, have been found to correlate with tumorigenesis, tissue invasiveness, metastatic behavior, and survival in many types of cancer, including breast cancer [25,26]. Breast cancer presents the highest incidence of all tumors and is still the first cause of death from cancer in women.…”

Section: Introductionmentioning

confidence: 99%

Single-Cell Probe Force Studies to Identify Sox2 Overexpression-Promoted Cell Adhesion in MCF7 Breast Cancer Cells

Iturri

Weber

Vivanco

et al. 2020

Cells

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The replacement of the cantilever tip by a living cell in Atomic Force Microscopy (AFM) experiments permits the direct quantification of cell–substrate and cell–cell adhesion forces. This single-cell probe force measurement technique, when complemented by microscopy, allows controlled manipulation of the cell with defined location at the area of interest. In this work, a setup based on two glass half-slides, a non-fouling one with bacterial S-layer protein SbpA from L. sphaericus CMM 2177 and the second with a fibronectin layer, has been employed to measure the adhesion of MCF7 breast cancer cells to fibronectin films (using SbpA as control) and to other cells (symmetric vs. asymmetric systems). The measurements aimed to characterize and compare the adhesion capacities of parental cells and cells overexpressing the embryonic transcription factor Sox2, which have a higher capacity for invasion and are more resistant to endocrine therapy in vivo. Together with the use of fluorescence techniques (epifluorescence, Total Internal Fluorescence Microscopy (TIRF)), the visualization of vinculin and actin distribution in cells in contact with fibronectin surfaces is enabled, facilitating the monitoring and quantification of the formation of adhesion complexes. These findings demonstrate the strength of this combined approach to assess and compare the adhesion properties of cell lines and to illustrate the heterogeneity of adhesive strength found in breast cancer cells.

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Section: Introductionmentioning

confidence: 99%

Single-Cell Probe Force Studies to Identify Sox2 Overexpression-Promoted Cell Adhesion in MCF7 Breast Cancer Cells

Iturri

Weber

Vivanco

et al. 2020

Cells

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“…HPSE expression strongly correlates with poor survival in BC (Sun et al, 2017) and serum levels of shed SDC1 have been identified to be informative in regards to progression of several cancers including breast (Joensuu et al, 2002;Vassilakopoulos et al, 2005;Szarvas et al, 2016). Shed SDC1 abundance detected in serum has been associated with BC size (Malek-Hosseini et al, 2017), and to be a result of chemotherapy (Ramani and Sanderson, 2014). SDC1 gene expression in BC can be prognostic (Cui et al, 2017), with its induction in stromal fibroblasts identified in invasive BC (Yang et al, 2011;Vlodavsky et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

Huang

Reye

Momot

et al. 2020

Front. Cell Dev. Biol.

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Huang et al. HPSE/SDC1 Axis Affects Mammographic Density parallel collagen alignment, reduced the abundance of fibrillar collagen as assessed by picrosirius red viewed under polarized light, and reduced MD. Our results reveal a potential role for HPSE in maintaining MD via its direct regulation of SDC1, which in turn physically tethers collagen into aligned fibers characteristic of MD. We propose that inhibitors of HPSE and/or SDC1 may afford an opportunity to reduce MD in high BC risk individuals and reduce MD-associated BC progression in conjunction with established BC therapies.

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“…63,70 The MMP-9-mediated shedding of syndecan-1 and -4 by HeLa cells involves ECM degradation during cancer cell metastasis and invasion, and shed syndecan-1 is involved in tumor cell proliferation. 68 A positive correlation between shed syndecan-1 levels and tumor size was reported in breast tumor progression, 71 and shed syndecan-1 was shown to bind activated vascular endothelial growth factor receptor 2 (VEGFR2) and thereby stimulate tumor cell invasion, 72 suggesting that it is involved in tumor angiogenesis. Heparanase-1, which is upregulated in many human tumors in association with increases in the metastatic potential of tumor cells, regulates syndecan-1 expression and shedding to influence breast cancer progression.…”

Section: Syndecan Shedding and Ecm Remodeling In Cancer Cellsmentioning

confidence: 99%

Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer

Jang

Kim

Hwang

et al. 2020

J Histochem Cytochem.

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The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly common in the development of cancer. The ECM has been recognized as a key driver of cancer development and progression, and ECM remodeling occurs at all stages of cancer progression. Thus, cancer cells need to change the ECM to support relevant cell surface adhesion receptor–mediated cell functions. In this context, it is interesting to examine how cancer cells regulate ECM remodeling, which is critical to tumor malignancy and metastatic progression. Here, we review how the cell surface adhesion receptor, syndecan, regulates ECM remodeling as cancer progresses, and explore how this can help us better understand ECM remodeling under these pathological conditions

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Elevated Syndecan-1 levels in the sera of patients with breast cancer correlate with tumor size

Abstract: The positive correlation between soluble Syndecan-1 levels and tumor size in the present study highlights the importance of different varieties (cell-bound and soluble) of this molecule in the breast tumor progression and their significance as tumor biomarkers.

Cited by 19 publications

References 34 publications

Single-Cell Probe Force Studies to Identify Sox2 Overexpression-Promoted Cell Adhesion in MCF7 Breast Cancer Cells

Single-Cell Probe Force Studies to Identify Sox2 Overexpression-Promoted Cell Adhesion in MCF7 Breast Cancer Cells

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer

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