Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma

He, Xiaoyun; Liao, Yun; Lu, Wen; Xu, Gufeng; Tong, Huan; Ke, Jieqi; Wan, Xiaoping

doi:10.1007/s13277-016-4869-5

Cited by 20 publications

(22 citation statements)

References 21 publications

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“…In hepatoma HCCLM3 cells, studies found that STMN1 siRNA could obviously inhibit cell proliferation and migration (24). In human endometrial carcinoma (EC) cell line Ishikawa, STMN1 was further identified showing a positive effect on cell viability and migration (25). In agreement with previous reports, our studies in vitro suggested that reduced expression of STMN1 in FaDu cells obviously induced a cell cycle arrest in G1 phase, accompanied by inhibited cell viability.…”

Section: Discussionmentioning

confidence: 99%

Stathmin1 overexpression in hypopharyngeal squamous cell carcinoma: A new promoter in FaDu cell proliferation and migration

Chen

Zhang

Ding

et al. 2016

International Journal of Oncology

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Stathmin1, a microtubule-destabilizing phosphoprotein, is considered to play a crucial role in regulating cellular microtubule dynamics and controlling mitosis. Previous studies have showed that STMN1 is highly expressed in many human malignancies and is related to development, invasion and metastasis of tumors. However, its expression pattern, clinical performance and functional roles in hypopharyngeal squamous cell carcinoma (HSCC) have not been addressed. In this study, we found that STMN1 was significantly elevated in HSCC and its expression level was correlated with poor differentiation (P<0.001), clinical stage (P<0.001), large tumor size (P=0.001) and lymph node metastasis (P=0.008). A positive correlation between STMN1 and Ki-67 expression was also exhibited. High STMN1 expression predicted poor survival. Furthermore, we found that knockdown of STMN1 by siRNAs inhibited the FaDu cell proliferation and migration. Moreover, decreased STMN1 expression in FaDu cells reversed the acquisition of EMT phenotype by upregulating E-cadherin, as well as reduced vimentin expression at protein and mRNA levels. These results suggested that STMN1 plays an important role in proliferation and migration of HSCC and may be used as a potential prognostic biomarker or therapeutic target of HSCC.

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Section: Discussionmentioning

confidence: 99%

Stathmin1 overexpression in hypopharyngeal squamous cell carcinoma: A new promoter in FaDu cell proliferation and migration

Chen

Zhang

Ding

et al. 2016

International Journal of Oncology

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“…There are two sites, observed in seven of the omics studies: STMN1 S‐25 and TPR S‐2155, which are direct ERK targets. STMN‐1 is responsible for microtubule filament organization, which plays a role in tumor growth and invasion , the S‐25 phosphorylation site on this oncoprotein is known to play a role in metastasis. TPR is a member of the nuclear pore complex that regulates the transport of mRNA and some proteins such as ERK and it also plays a role in mitosis .…”

Section: Analysis Of the Erk Target Sitesmentioning

confidence: 99%

A compendium of ERK targets

2017

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Edited by Wilhelm JustThe RAF-MEK-ERK cascade is one of the most studied signaling pathways as it controls many vital cellular programs. There has been an immense amount of effort to determine ERK target proteins involved in regulating these programs. Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho-proteomic technologies, numerous studies have expanded the number of ERK target proteins. Here, we compile a comprehensive ERK target phospho-site archive, in which we gathered information from various research studies, and we provide this archive as an online database to form a searchable compendium of ERK targets.

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“…Stathmin 1 (STMN1), a major microtubule-depolymerizing protein, serves as a prognostic marker for multiple cancers, including NSCLC,15 gallbladder carcinoma,16 and colon cancer 17. STMN1 has been found to destabilize microtubules and plays an important role in the regulation of cell cycle progression and tumor metastasis 18,19…”

Section: Introductionmentioning

confidence: 99%

Silencing of miR-1247 by DNA methylation promoted non-small-cell lung cancer cell invasion and migration by effects of STMN1

Zhang¹,

Fu²,

Pan³

et al. 2016

OTT

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MicroRNAs (miRNAs) play an important role in cancer development and progression, altering several biological functions by affecting targets through either degradation of mRNAs or suppression of protein translation. One such miRNA, miR-1247, is downregulated in various cancers, but its biological role in non-small-cell lung cancer (NSCLC) is unknown. This study found that the expression of miR-1247 was significantly reduced in NSCLC cell lines and tumor tissues compared with matched normal lung tissues and cell lines as a result of DNA hypermethylation. Overexpression of miR-1247 or demethylation by 5-azacytidine (5-Aza) treatment dramatically inhibited cell growth, migration, invasion, and cell cycle progression. Furthermore, Stathmin 1 (STMN1) was found to be an immediate and functional target of miR-1247. The expression of STMN1 was significantly increased in NSCLC cell lines but was decreased by 5-Aza treatment. In addition, miR-1247 upregulation partially inhibited STMN1-induced promotion of migration and invasion of A549 and H1299 cells. The results suggest that miR-1247 was silenced by DNA methylation. MiR-1247 and its downstream target gene STMN1 may therefore be a future target for the treatment of NSCLC.

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Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma

Cited by 20 publications

References 21 publications

Stathmin1 overexpression in hypopharyngeal squamous cell carcinoma: A new promoter in FaDu cell proliferation and migration

Stathmin1 overexpression in hypopharyngeal squamous cell carcinoma: A new promoter in FaDu cell proliferation and migration

A compendium of ERK targets

Silencing of miR-1247 by DNA methylation promoted non-small-cell lung cancer cell invasion and migration by effects of STMN1

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