Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: A cytokine antibody array analysis

Lu, Shengyong; Peng, Hongjun; Wang, Lifeng; Seewoobudul, Vasish; Zhang, Yan; Gao, Weijia; Wu, Weiwei; Liao, Mei; Wang, Mi; Tang, Hao; Li, Wenping; Li, Weihui; Li, Zexuan; Zhou, Jiansong; Zhang, Zhijun; Li, Lingjiang

doi:10.1016/j.comppsych.2013.03.026

Cited by 92 publications

(69 citation statements)

References 52 publications

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“…In addition, we re-included one article in the meta-analysis of correlations between VEGF and severity of disease (Isung et al, 2012). The results of the literature search are listed in Table 1 (Berent et al, 2014;Carvalho et al, 2014Carvalho et al, , 2013Clark-Raymond et al, 2014;Dalby et al, 2013;Dome et al, 2009;Elfving et al, 2014;Fornaro et al, 2013;Galecki et al, 2013a;Kahl et al, 2009;Kotan et al, 2012;Lee and Kim, 2012;Lu et al, 2013;Schweiger et al, 2008;Takebayashi et al, 2010;Ventriglia et al, 2009). …”

Section: Studies Included In the Current Meta-analysismentioning

confidence: 99%

“…Similarly, during step 3, we subdivided the studies according to the sample source used in the studies into the serum sample subgroup (Berent et al, 2014;Carvalho et al, 2014Carvalho et al, , 2013Elfving et al, 2014;Galecki et al, 2013a;Kahl et al, 2009;Kotan et al, 2012;Schweiger et al, 2008;Ventriglia et al, 2009) and the plasma sample subgroup (ClarkRaymond et al, 2014;Dalby et al, 2013;Dome et al, 2009;Fornaro et al, 2013;Lee and Kim, 2012;Lu et al, 2013;Takebayashi et al, 2010 …”

Section: Meta-analysis Of Vegf Using Serum or Plasma Samplesmentioning

confidence: 99%

“…Isung and colleagues recruited a group who had attempted suicide, most of whom fulfilled the diagnosis of mood disorders in DSM (Diagnostic and Statistical Manual of Mental Disorders) axis I, and found lower VEGF levels in their cerebrospinal fluid than in healthy controls (Isung et al, 2012). In addition, many studies have demonstrated an increase in peripheral VEGF in MDD patients compared with healthy controls, either in serum (Berent et al, 2014;Carvalho et al, 2014;Elfving et al, 2014;Galecki et al, 2013a;Kahl et al, 2009;Schweiger et al, 2008) or plasma (Lee and Kim, 2012;Lu et al, 2013;Takebayashi et al, 2010). However, some studies have reported inconsistent findings.…”

Section: Introductionmentioning

confidence: 96%

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Increased levels of vascular endothelial growth factor in patients with major depressive disorder: A meta-analysis

Tseng¹,

Cheng²,

Chen

et al. 2015

European Neuropsychopharmacology

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Section: Studies Included In the Current Meta-analysismentioning

confidence: 99%

Section: Meta-analysis Of Vegf Using Serum or Plasma Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Increased levels of vascular endothelial growth factor in patients with major depressive disorder: A meta-analysis

Tseng¹,

Cheng²,

Chen

et al. 2015

European Neuropsychopharmacology

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“…The cutoffs of each sub-scale for moderate-severe exposure are: 1) emotional abuse $13, 2) emotional neglect $15, 3) sexual abuse $8, 4) physical abuse $10, and 5) physical neglect $10. This reliable questionnaire has great internal consistency and criterion-related validity in clinical and community samples; the good internal consistency coefficients for the five subscales are demonstrated in many studies [19,20,21,22].…”

Section: Assessment Of Childhood Traumamentioning

confidence: 99%

Reduced Cingulate Gyrus Volume Associated with Enhanced Cortisol Awakening Response in Young Healthy Adults Reporting Childhood Trauma

Lu¹,

Gao²,

Wei³

et al. 2015

Holistic Perspectives on Trauma

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Background: Preclinical studies have demonstrated the relationship between stress-induced increased cortisol levels and atrophy of specific brain regions, however, this association has been less revealed in clinical samples. The aim of the present study was to investigate the changes and associations of the hypothalamic-pituitary-adrenal (HPA) axis activity and gray matter volumes in young healthy adults with self-reported childhood trauma exposures.

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“…There were a number of studies investigating cytokines in those with a history of childhood maltreatment, both in healthy adults (26) and in adults with MDD (27). There were also more studies investigating the role of the inflammatory marker C-reactive protein (CRP) in adults with MDD and a history of early childhood adversity (28,29).…”

Section: Chaptermentioning

confidence: 99%

The role of cytokines and inflammatory markers in depression in adolescents

Mills¹

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Aims: The overarching hypothesis is that circulating levels of pro-inflammatory cytokines and other inflammatory markers are genetically associated with depression in adolescents.Specifically, it is hypothesised that there will be a correlation between variation in genetic risk of depression and genetic variation of circulating pro-inflammatory cytokines and inflammatory markers. Methods:A systematic review of the literature was conducted to establish the current understanding of the relationship between inflammatory markers and depression in adolescents and to inform study design. Multiple approaches (including different types of genetic analyses and multiple data sets) were used to address the overarching hypothesis.A pilot study measuring cytokines, inflammatory markers, and other biomarkers involved in immune regulation (including Vitamin D, antibodies to infectious agents, and gliadin antibodies (found in coeliac disease)) was conducted in 107 monozygotic (MZ) and 160 dizygotic (DZ) twin pairs (mean age 16.2 years, standard deviation (SD) 0.25 years) from the Brisbane Adolescent Twin Study. A clinical study was undertaken to collect biological samples and clinical data from an in-patient adolescent mental health unit. Investigation of the relationship between iron measures (altered in inflammatory states)and measures of depression was undertaken in community cohorts of twins and their parents (3,416 adolescents from 1,688 families, and 9,035 adults from 4,533 families). In the adolescent cohort, depressive measures were assessed through the Somatic and Psychological Health Report (SPHERE) (mean age 15.1 years (SD 3.2 years)). In the adult cohort, a quantitative score of depression was measured by the Delusions Symptoms State Inventory (DSSI) (mean age 23.2 years (SD 2.2 years)). Heritabilities of, and phenotypic and genetic correlations between, traits were estimated. Association analyses, genetic profile risk score analyses, and LD score analyses were also used to investigate the genetic relationship between the iron and depression measures. Genetic profile risk score analyses were used to explore the genetic relationship between these variables. Results:In the pilot study, cytokines that were successfully measured in plasma were found to be moderately heritable (transforming growth factor-β1 (TGFβ1), 0.57 (95% CI 0.26 -0.80) and tumour necrosis factor-receptor type 1 (TNFR1), 0.50 (95% CI 0.11-0.63)). A negative correlation between Vitamin D and the cytokine IL-18 (-0.14) was not statistically significant (p=0.054). However, major difficulties were encountered in measuring cytokines, in particular due to the low levels of circulating cytokines in healthy adolescents. Challenges were also encountered in the cytokines study of the clinical sample of adolescents, which were able to be broadly divided into patient factors, blood collection factors, and other data collection factors.Iron measures were found to be highly heritable in both adolescents and adults: The relationship between CRP and Major D...

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Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: A cytokine antibody array analysis

Cited by 92 publications

References 52 publications

Increased levels of vascular endothelial growth factor in patients with major depressive disorder: A meta-analysis

Increased levels of vascular endothelial growth factor in patients with major depressive disorder: A meta-analysis

Reduced Cingulate Gyrus Volume Associated with Enhanced Cortisol Awakening Response in Young Healthy Adults Reporting Childhood Trauma

The role of cytokines and inflammatory markers in depression in adolescents

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