Elevated serum uric acid is associated with incident hypertension in the health according to various contemporary blood pressure guidelines

Liu, Cheng Wei; Ke, Shin‐Rong; Tseng, Guo-Shiang; Wu, Yen‐Wen; Hwang, Juey‐Jen

doi:10.1016/j.numecd.2021.01.003

Cited by 12 publications

(12 citation statements)

References 31 publications

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“…Many experimental studies suggest that UA may play a casual role in the development of hypertension (14,15). Hyperuricemia induced hypertension, which can be prevented by UA-lowering treatment (35). Hyperuricemia has been shown to stimulate the renin-angiotensin system, inhibit neuronal nitric oxide synthase and induce endothelial dysfunction (35,36).…”

Section: Uamentioning

confidence: 99%

“…Hyperuricemia induced hypertension, which can be prevented by UA-lowering treatment (35). Hyperuricemia has been shown to stimulate the renin-angiotensin system, inhibit neuronal nitric oxide synthase and induce endothelial dysfunction (35,36). In addition, UA has been reported to induce trophoblastic production of pro-inflammatory interleukin-1β through activation of inflammatory pathways (37).…”

Section: Uamentioning

confidence: 99%

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Increased Uric Acid, Gamma-Glutamyl Transpeptidase and Alkaline Phosphatase in Early-Pregnancy Associated With the Development of Gestational Hypertension and Preeclampsia

Chen

Ou²,

Lin³

et al. 2021

Front. Cardiovasc. Med.

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Background: Previous studies have reported that biomarkers of liver injury and renal dysfunction were associated with hypertensive disorders of pregnancy (HDP). However, the associations of these biomarkers in early pregnancy with the risk of HDP and longitudinal blood pressure pattern during pregnancy were rarely investigated in prospective cohort studies.Methods: A total of 1,041 pregnant women were enrolled in this prospective cohort study. BP was assessed in four stages throughout pregnancy. The following biomarkers were measured at early pregnancy before 18 weeks gestation: lactate dehydrogenase (LDH), aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), uric acid (UA), and estimated glomerular filtration rate (eGFR). Linear mixed-effects and logistic regression models were used to examine the associations of these biomarkers with longitudinal BP pattern during pregnancy and HDP incidence, respectively.Results: In unadjusted models, higher serum UA, GGT, ALP, and LDH levels, as well as lower eGFR and AST/ALT, were associated with higher BP levels during pregnancy and an increased risk of HDP. After adjustment for maternal age, pre-pregnancy BMI and other potential confounders, UA, GGT, ALP, and LDH remained positively associated with both BP and HDP. However, eGFR and AST/ALT were not associated with HDP after adjusting for potential confounders. When including all 6 biomarkers simultaneously in multivariable analyses, increased UA, GGT, and ALP significantly associated with gestational hypertension and preeclampsia.Conclusion: This study suggests that increased UA, GGT, and ALP in early-pregnancy are independent risk factors of gestational hypertension and preeclampsia.

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Section: Uamentioning

confidence: 99%

Section: Uamentioning

confidence: 99%

Increased Uric Acid, Gamma-Glutamyl Transpeptidase and Alkaline Phosphatase in Early-Pregnancy Associated With the Development of Gestational Hypertension and Preeclampsia

Chen

Ou²,

Lin³

et al. 2021

Front. Cardiovasc. Med.

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“…In contrast to the HUA, the AH is insidious. Continuous research has shown that continuously increasing UA levels are also closely related to many diseases, such as diabetes [ 2 ], hypertension [ 3 ], stroke [ 4 ], and myocardial infarction [ 5 ]. It also suggests the great harm of the AH.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

et al. 2021

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Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH.

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“…Our study was previously registered at ClinicalTrials.gov with the identi cation number NCT03473951 (Ref. [30]). Furthermore, data were deidenti ed and meet privacy rules of the health insurance portability and accountability act (HIPAA).…”

Section: A Study Cohortmentioning

confidence: 99%

Left Ventricular Hypertrophy Detection Using Electrocardiographic Signal

Wu²,

et al. 2022

Preprint

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Left ventricular hypertrophy (LVH) indicates subclinical organ damage, associating with the incidence of cardiovascular diseases. From the medical perspective, electrocardiogram (ECG) is a low-cost, non-invasive, and easily reproducible tool that is often used as a preliminary diagnosis for the detection of heart disease. Nowadays, there are many criteria for assessing LVH by ECG. These criteria usually include that voltage combination of RS peaks in multi-lead ECG must be greater than one or more thresholds for diagnosis. We developed a system for detecting LVH using ECG signals by two steps: firstly, the R-peak and S-valley amplitudes of the 12-lead ECG were extracted to automatically obtain a total of 24 features and ECG beats of each case (LVH or non-LVH) were segmented; secondly, a back propagation neural network (BPN) was trained using a dataset with these features. Echocardiography (ECHO) was used as the gold standard for diagnosing LVH. The number of LVH cases (of a Taiwanese population) identified was 173. As each ECG sequence generally included 8 to 13 cycles (heartbeats) due to differences in heart rate, etc., we identified 1466 ECG cycles of LVH patients after beat segmentation. Results showed that our BPN model for detecting LVH reached the testing accuracy, precision, sensitivity, and specificity of 0.961, 0.958, 0.966 and 0.956, respectively. Detection performances of our BPN model, on the whole, outperform 7 methods using ECG criteria and many ECG-based artificial intelligence (AI) models reported previously for detecting LVH.

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Elevated serum uric acid is associated with incident hypertension in the health according to various contemporary blood pressure guidelines

Cited by 12 publications

References 31 publications

Increased Uric Acid, Gamma-Glutamyl Transpeptidase and Alkaline Phosphatase in Early-Pregnancy Associated With the Development of Gestational Hypertension and Preeclampsia

Increased Uric Acid, Gamma-Glutamyl Transpeptidase and Alkaline Phosphatase in Early-Pregnancy Associated With the Development of Gestational Hypertension and Preeclampsia

Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

Left Ventricular Hypertrophy Detection Using Electrocardiographic Signal

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