“…UCH-L1 is highly expressed throughout the central and peripheral nervous systems, but only in tracal quantities in the large intestine, kidney, ovary, and testis (Orr et al, 2011). This marker is involved in protein binding, proteasome-mediated ubiquitination, sensory pain perception, maintenance of the axonal integrity, axon target recognition, neuroendocrine cell protection, proteolysis, neuromuscular process, muscle fibre development, and traumatic brain injury (Papa et al, 2010;Blyth et al, 2011;Wilson et al, 2016). Therefore, the ubiquitin system plays significant roles in the regulation of many cellular and biological processes.…”