Elevated Serum Total IgE – A Potential Marker for Severe Chronic Urticaria

Abstract

Background: Elevated IgE levels in patients with chronic urticaria have been noted previously, but the significance of these findings has not been appreciated. Objective: To measure the IgE levels in such patients and to examine the relationship between these levels and urticarial severity, autologous serum skin test, anti-thyroid antibodies and duration. Methods: Serum total IgE levels from 203 patients with chronic urticaria were measured and compared with nonatopic individuals. Additionally, patients were assessed for urticarial severity, the presence of autologous serum skin test and anti-thyroid antibodies. Results: Of the chronic urticaria patients, 47 (23.2%) were classified as mild, whereas 67 (33%) were classified as having moderate and 89 (43.8%) as having severe chronic urticaria. Total IgE levels were elevated, above 175 U/ml, in 69/203 (34%) of patients, compared with 7/81 (8.6%) of healthy controls (p < 0.001). A significant association between increased total IgE and chronic urticaria severity was found. Whereas 93% of patients with increased level of total IgE suffered from moderate-to-severe chronic urticaria, this was observed in only 69% of patients with normal IgE (p < 0.0001). Autologous serum skin test and anti-thyroid antibodies were positive in 59/163 (36%) and 28/189 (15%) patients, respectively. A significant association between increased total IgE levels and the presence of autologous serum skin test, anti-thyroid antibodies and urticarial duration lasting more than 25 months (p < 0.0001, p < 0.0001 and p = 0.021, respectively) was also detected. Conclusions: Total serum IgE levels are frequently elevated in patients with chronic urticaria and these are associated with disease severity and duration.

Multiple Nonsteroidal Anti-Inflammatory Drug-Induced Cutaneous Disease: Relevance, Natural Evolution and Relationship with Atopy

“…Our data highlighting the high prevalence of atopy in patients with HRs to NSAIDs are in line with other studies [10,11,12]. In general, other studies have also supported the role of atopy in chronic urticaria [13,14]. In our experience, atopy (defined as the percentage of positive skin prick test results to inhalant allergens) is present in around 25% of CSU patients [unpubl.…”

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

“…Two articles [5,17] reported the association between serum immunoglobulin E (IgE) and CSU duration. Elevated total IgE levels were described in 32/139 (23%) [5] and in 69/203 (34%) [17] patients.…”

CRP, D-dimer, fibrinogen and ESR as predictive markers of response to standard doses of levocetirizine in patients with chronic spontaneous urticaria

“…Levocetirizine was more often effective in patients with mild CSU compared to those with severe disease (66. 7 and co-workers where total IgE was suggested as a marker of severe CSU (7). Thus, the role of total IgE in CSU should be better characterized in further research.…”