Elevated serum soluble CD44 level in sarcoidosis.

Kasuga, Ikuma; Minemura, Kazushige; Nasu, Hidekazu; Hibi, Nozomu; Tago, H; Nagate, Akira; Kunisawa, Akira; Ohyashiki, Junko H.; Ohyashiki, Kazuma

doi:10.3892/ijmm.6.6.679

Cited by 3 publications

(2 citation statements)

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“…However, no difference was found in smokers or in the non-Löfgren group. Kasuga et al evaluated soluble CD44 in the serum (sCD44) of 13 sarcoidosis patients and 56 controls, as well as in the BALF of 11 sarcoidosis patients and 10 controls (41). In patients with sarcoidosis, the serum CD44 level was significantly higher than that of controls.…”

Section: Discussionmentioning

confidence: 99%

CD31+, CD38+, CD44+, and CD103+ lymphocytes in peripheral blood, bronchoalveolar lavage fluid and lung biopsy tissue in sarcoid patients and controls

Aleksonienė¹,

Besusparis²,

Gruslys³

et al. 2021

J Thorac Dis

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Background: The mechanisms driving the transition from inflammation to fibrosis in sarcoidosis patients are poorly understood; prognostic features are lacking. Immune cell profiling may provide insights into pathogenesis and prognostic factors of the disease. This study aimed to establish associations in simultaneous of lymphocyte subset profiles in the blood, bronchoalveolar lavage fluid (BALF), and lung biopsy tissue in the patients with newly diagnosed sarcoidosis.Methods: A total of 71 sarcoid patients (SPs) and 20 healthy controls (HCs) were enrolled into the study. CD31, CD38, CD44, CD103 positive T lymphocytes in blood and BALF were analysed. Additionally, the densities of CD4, CD8, CD38, CD44, CD103 positive cells in lung tissue biopsies were estimated by digital image analysis. Results: Main findings: (I) increase of percentage of CD3 + CD4 + CD38 + in BALF and blood, and increase of percentage of CD3 + CD4 + CD44 + in BALF in Löfgren syndrome patients comparing with patients without Löfgren syndrome, (II) increase of percentage of CD3 + CD4 + 103 + in BALF and in blood in patients without Löfgren syndrome (comparing with Löfgren syndrome patients) and increase of percentage of CD3 + CD4 + 103 + in BALF and in blood in more advanced sarcoidosis stage. (III) Increasing percentage of BALF CD3 + CD4 + CD31 + in sarcoidosis patients when comparing with controls independently of presence of Löfgren syndrome, smoking status or stage of sarcoidosis. Several significant correlations were found. Conclusions: Lymphocyte subpopulations in blood, BALF, and lung tissue were substantially different in SPs at the time of diagnosis compared to HCs. CD3 + CD4 + CD31 + in BALF might be a potential supporting marker for the diagnosis of sarcoidosis. CD3 + CD4 + CD38 + in BALF and blood and CD3 + CD4 + CD44 + in BALF may be markers of the acute immune response in sarcoidosis patients. CD4 + CD103 + T-cells in BALF and in blood are markers of the persistent immune response in sarcoidosis patients and are potential prognostic features of the chronic course of this disease.

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Section: Discussionmentioning

confidence: 99%

CD31+, CD38+, CD44+, and CD103+ lymphocytes in peripheral blood, bronchoalveolar lavage fluid and lung biopsy tissue in sarcoid patients and controls

Aleksonienė¹,

Besusparis²,

Gruslys³

et al. 2021

J Thorac Dis

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“…CD44 mediates adhesion to the endothelium and extracellular matrix and its expression on lymphocytes in pulmonary sarcoidosis, as well as other mucosal disorders such as Crohn's disease, has been speculated to influence their homing and activation, in addition to stimulating macrophage differentiation [36]. Furthermore, elevated levels of soluble CD44 have been demonstrated in conditions with an autoimmune background, including sarcoidosis [37,38], suggesting involvement in cell-cell communication. Recently, LINKE et al [39] discovered increased activity of mechanistic target of rapamycin (mTOR) complexes in sarcoid granulomas of patients with active progressive disease, compared to patients undergoing remission.…”

Section: Granulomatous Structures and Signallingmentioning

confidence: 99%

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

2019

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Despite more than a century of research, the causative agent(s) in sarcoidosis, a heterogeneous granulomatous disorder mainly affecting the lungs, remain(s) elusive. Following identification of genetic factors underlying different clinical phenotypes, increased understanding of CD4+ T-cell immunology, which is believed to be central to sarcoid pathogenesis, as well as the role of B-cells and other cells bridging innate and adaptive immunity, contributes to novel insights into the mechanistic pathways influencing disease resolution or chronicity. Hopefully, new perspectives and state-of-the-art technology will help to shed light on the still-elusive enigma of sarcoid aetiology. This perspective article highlights a number of recent advances in the search for antigenic targets in sarcoidosis, as well as the main arguments for sarcoidosis as a spectrum of autoimmune conditions, either as a result of an external (microbial) trigger and/or due to defective control mechanisms regulating the balance between T-cell activation and inhibition.

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Proteolytic Processing of CD44 and Its Implications in Cancer

Medrano-González¹,

Rivera-Ramírez²,

Montaño³

et al. 2021

Stem Cells International

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CD44 is a transmembrane glycoprotein expressed in several healthy and tumor tissues. Modifications in its structure contribute differently to the activity of this molecule. One modification that has provoked interest is the consecutive cleavage of the CD44 extracellular ectodomain by enzymes that belong mainly to the family of metalloproteases. This process releases biologically active substrates, via alternative splice forms of CD44, that generate CD44v3 or v6 isoforms which participate in the transcriptional regulation of genes and proteins associated to signaling pathways involved in the development of cancer. These include the protooncogene tyrosine-protein kinase Src (c-Src)/signal transducer and activator of transcription 3 (STAT3), the epithelial growth factor receptor, the estrogen receptor, Wnt/βcatenin, or Hippo signaling pathways all of which are associated to cell proliferation, differentiation, or cancer progression. Whereas CD44 still remains as a very useful prognostic cell marker in different pathologies, the main topic is that the generation of CD44 intracellular fragments assists the regulation of transcriptional proteins involved in the cell cycle, cell metabolism, and most importantly, the regulation of some stem cell-associated markers.

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Elevated serum soluble CD44 level in sarcoidosis.

Cited by 3 publications

References 0 publications

CD31+, CD38+, CD44+, and CD103+ lymphocytes in peripheral blood, bronchoalveolar lavage fluid and lung biopsy tissue in sarcoid patients and controls

CD31+, CD38+, CD44+, and CD103+ lymphocytes in peripheral blood, bronchoalveolar lavage fluid and lung biopsy tissue in sarcoid patients and controls

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

Proteolytic Processing of CD44 and Its Implications in Cancer

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