Elevated serum progesterone does not impact euploidy rates in PGT-A patients

Pardiñas, Maria Luisa; Nohales, Mar; Labarta, Elena; Santos, J.M. De los; Mercader, Amparo; Remohı́, José; Bosch, Ernesto; Santos, María José de los

doi:10.1007/s10815-021-02197-y

Cited by 9 publications

(11 citation statements)

References 29 publications

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“…However, this result again did not reach statistical significance. Some contradictory findings have reported comparable top-quality blastocyst development rates between cycles with or without premature P 4 elevation [ 22 , 23 ]. In our study, E 2 levels were also significantly higher in the GnRHa group than in the CC+hMG group.…”

Section: Discussionmentioning

confidence: 99%

Effects of controlled ovarian stimulation regimens on top-quality blastocyst development and perinatal outcomes with the freeze-all strategy: A retrospective comparative study

Bhor¹,

Nakayama²,

Ono³

et al. 2023

Clin Exp Reprod Med

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Objective: This study aimed to determine the effect of ovarian stimulation regimens on the top-quality blastocyst development rate and perinatal outcomes with the freeze-all strategy. Methods: A retrospective comparative cohort analysis of 149 in vitro fertilization (IVF) cycles using the freeze-all strategy was conducted. The IVF cycles were stimulated with either a gonadotropin-releasing hormone antagonist or clomiphene citrate along with gonadotropin based on the patient’s serum anti-Müllerian hormone level. Oocyte retrieval, fertilization, and embryo culture were performed following standard procedures. All good-quality blastocysts were cryopreserved and used for frozen-thawed embryo transfer (FET) in subsequent cycles. The fertilization, blastulation, and top-quality blastocyst development rates were calculated. The perinatal outcomes of FET cycles, gestational period, and birth weight were assessed. Results: The main outcome of this study was the top-quality blastocyst development rate, and the secondary outcomes were perinatal parameters (e.g., gestational period and birth weight) between the stimulation regimens. Despite the higher number of usable-quality embryos in the antagonist group, the blastocyst development rate remained comparable (p=0.105). Similarly, perinatal outcomes were comparable in subsequent FET cycles (p=0.538).Conclusion: These findings suggest that the choice between antagonist and clomiphene citrate with gonadotropin as stimulation in controlled ovarian stimulation regimens may not affect the top-quality blastocyst development rate. The IVF outcomes (e.g., clinical pregnancy, miscarriage, and live birth rates) remained unaffected in subsequent FET cycles. Unlike fresh embryo transfer, the birth weight and gestational length were not associated with prior controlled ovarian stimulation regimens when the freeze-all strategy was used.

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Section: Discussionmentioning

confidence: 99%

Effects of controlled ovarian stimulation regimens on top-quality blastocyst development and perinatal outcomes with the freeze-all strategy: A retrospective comparative study

Bhor¹,

Nakayama²,

Ono³

et al. 2023

Clin Exp Reprod Med

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“…The impact of premature progesterone elevation on the fertilization potential of retrieved oocytes was analyzed in OS cycles resulting in IVF with frozen and fresh ET cycles. Again, those with premature progesterone elevation exhibited similar or increased fertilization rates and a similar number of euploid embryos, embryos transferred, and embryos cryopreserved [27,79,80,[82][83][84][85][86][87]. To better understand the impact of premature progesterone elevation on the quality of these embryos, various embryo development rates were analyzed.…”

Section: Oocyte and Embryo Qualitymentioning

confidence: 99%

Towards an Improved Understanding of the Effects of Elevated Progesterone Levels on Human Endometrial Receptivity and Oocyte/Embryo Quality during Assisted Reproductive Technologies

Kalakota

George

Morelli

et al. 2022

Cells

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Ovarian stimulation is an indispensable part of IVF and is employed to produce multiple ovarian follicles. In women who undergo ovarian stimulation with gonadotropins, supraphysiological levels of estradiol, as well as a premature rise in progesterone levels, can be seen on the day of hCG administration. These alterations in hormone levels are associated with reduced embryo implantation and pregnancy rates in IVF cycles with a fresh embryo transfer. This article aims to improve the reader’s understanding of the effects of elevated progesterone levels on human endometrial receptivity and oocyte/embryo quality. Based on current clinical data, it appears that the premature rise in progesterone levels exerts minimal or no effects on oocyte/embryo quality, while advancing the histological development of the secretory endometrium and displacing the window of implantation. These clinical findings strongly suggest that reduced implantation and pregnancy rates are the result of a negatively affected endometrium rather than poor oocyte/embryo quality. Understanding the potential negative impact of elevated progesterone levels on the endometrium is crucial to improving implantation rates following a fresh embryo transfer. Clinical studies conducted over the past three decades, many of which have been reviewed here, have greatly advanced our knowledge in this important area.

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“…[ 44 ] In few other studies, euploidy rate after preimplantation genetic testing (PGT) was similar in women with elevated P and LBR following transfer of such euploid embryos in FET cycles were not different. [ 45 46 47 48 ]…”

Section: P Remature P Rogesterone ...mentioning

confidence: 99%

“…[ 42 43 44 47 54 57 ] The euploidy rate after PGT-A was also similar in most studies. [ 45 46 47 48 ]…”

Section: E Levated P Rogesterone and ...mentioning

confidence: 99%

Premature progesterone elevation in in vitro fertilisation cycles – current perspectives

Gurunath

2022

J Hum Reprod Sci

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Elevated serum progesterone does not impact euploidy rates in PGT-A patients

Cited by 9 publications

References 29 publications

Effects of controlled ovarian stimulation regimens on top-quality blastocyst development and perinatal outcomes with the freeze-all strategy: A retrospective comparative study

Effects of controlled ovarian stimulation regimens on top-quality blastocyst development and perinatal outcomes with the freeze-all strategy: A retrospective comparative study

Towards an Improved Understanding of the Effects of Elevated Progesterone Levels on Human Endometrial Receptivity and Oocyte/Embryo Quality during Assisted Reproductive Technologies

Premature progesterone elevation in in vitro fertilisation cycles – current perspectives

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