Elevated Serum Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios Could be Useful in Lung Cancer Diagnosis

Abstract

Background: Lung cancer (LC) is still the primary cause of cancer deaths worldwide, and late diagnosis is a major obstacle to improving lung cancer outcomes. Recently, elevated preoperative or pretreatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) detected in peripheral blood were identified as independent prognostic factors associated with poor survival with various cancers, including colon cancer, esophageal cancer, gastric cancer and breast cancer. Objective: The aim of this study was to examine whether MPV, NLR and PLR could be useful inflammatory markers to differentiate lung cancer patients from healthy controls. An investigation was also made of the relationship between these markers and other prognostic factors and histopathological subgroups. Materials and Methods: Retrospectively eighty-one lung cancer patients and 81 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. The preoperative or pretreatment blood count data was obtained from the recorded computerized database. Results: NLR and PLR values were significantly higher in the LC patients compared to the healthy subjects.( NLR: 4.42 vs 2.45 p=0.001, PLR: 245.1 vs 148.2 p=0.002) MPV values were similar in both groups (7.7 vs 7.8). No statistically significant relationship was determined between these markers (MPV, NLR and PLR) and histopathological subgroups and TNM stages. Conclusions: NLR and PLR can be useful biomarkers in LC patients before treatment. Larger prospective studies are required to confirm these findings.

Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer

“…In the literature, increased N/L ratio was significantly related with the lung cancer (Kemal et al, 2014), gastric cancer (Kim et al, 2015), colon cancer (Absenger et al, 2013) and papillary thyroid cancer DOI:http://dx.doi.org/10.7314/APJCP.2016.17.4.2321 Inflammatory Hematological Parameters in Benign Nodular Goiter andPapillary Thyroid Cancer (Seretis et al, 2013).…”

Neutrophil to Lymphocyte Ratio - Not an Independent Prognostic Factor in Patients with the Myelodysplastic Syndrome

“…The relative difference in the neutrophil and lymphocyte counts, the neutrophilto-lymphocyte ratio (NLR), has attracted the interest of investigators as an emerging systemic inflammatory marker. A high preoperative or pretreatment NLR was identified as an independent prognostic factor associated with poor survival in various cancers, including breast cancer, colon cancer, lung cancer, and mesothelioma (He et al, 2014;Kemal et al, 2014). The pathogenesis and progression of the disease may be correlated to ovarian cancer; prognosis was found to be correlated with tumour volume in metastatic renal cell carcinoma, and there are reports that NLR may be a negative prognostic marker in thyroid carcinoma (Kim et al, 2013).…”

Volumen plaquetario medio, índice de neutrófilos/linfocitos e índice de trombocitos/linfocitos para determinar el diagnóstico y/o pronóstico en niños con mordedura de serpiente

“…[4][5][6]8 El VPM, el INL y el ITL se miden como parte de los análisis de sangre de rutina en muchos laboratorios sin que esto implique costos adicionales. 4,9 El VPM se asocia con la activación y la función de los trombocitos en las afecciones inflamatorias. 6,9 Los trombocitos son componentes vitales de la hemostasia normal y liberan varias citocinas proinflamatorias.…”

“…4,9 El VPM se asocia con la activación y la función de los trombocitos en las afecciones inflamatorias. 6,9 Los trombocitos son componentes vitales de la hemostasia normal y liberan varias citocinas proinflamatorias. 4,6,9 El VPM puede aumentar cuando se produce inflamación leve y puede disminuir en los casos de inflamación más grave debido al consumo demandante de trombocitos en las zonas de inflamación.…”

“…6,9 Los trombocitos son componentes vitales de la hemostasia normal y liberan varias citocinas proinflamatorias. 4,6,9 El VPM puede aumentar cuando se produce inflamación leve y puede disminuir en los casos de inflamación más grave debido al consumo demandante de trombocitos en las zonas de inflamación. 4 El VPM refleja las afecciones proinflamatorias, en las que las citocinas proinflamatorias regulan el proceso de inflamación.…”