Elevated serum neopterin levels in atherosclerosis

Tatzber, Franz; Rabl, Hans; Koriska, Karl; Erhart, U.; Puhl, Herbert; Waeg, Georg; Krebs, Angelika; Esterbauer, Hermann

doi:10.1016/0021-9150(91)90061-7

Cited by 116 publications

(65 citation statements)

References 17 publications

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“…It is of note that these elevations of immunologic parameters occurred despite the near absence of significant differences in the levels of atherosclerosis-associated metabolic parameters between patients with and those without atherosclerosis. Previous workers have shown an increase in the level of circulating immunologic parameters in atherosclerosis in both cross-sectional 22,23,27 and prospective 4,6,10,29,33,40 studies. Our study extends these results to show that a core inflammatory signature can be identified in the blood of patients with atherosclerotic disease.…”

Section: Discussionmentioning

confidence: 96%

“…23 The role of latent bacterial and viral infections in the pathogenesis of atherosclerosis has been the subject of much recent debate. 24 Neopterin, a specific marker of macrophage activation, 25 is commonly used to screen for subclinical viral infections 26 and has been found to be elevated in the circulation of patients with atherosclerosis of the carotid, 27 coronary, 28 and peripheral 29 arteries. Another newer marker of infection is the peptide hormone procalcitonin (PCT).…”

mentioning

confidence: 99%

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Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Erren

Reinecke

Junker

et al. 1999

ATVB

275

149

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Erren

Reinecke

Junker

et al. 1999

ATVB

275

149

View full text Add to dashboard Cite

show abstract

“…Increased neopterin concentrations have been reported in patients with atherosclerosis (53,54). Acute myocardial infarction is also accompanied by a marked rise in urinary neopterin concentrations (55).…”

Section: Neopterin As Biomarker Of Immune Activationmentioning

confidence: 99%

Neopterin as a biomarker of immune response in cancer patients

Melichar¹,

Spisarová²,

Bartoušková³

et al. 2017

Ann. Transl. Med.

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“…The increased cholesterol concenn'ations in membranes and decreased unsaturated fatty acid contents of membrane phospholipids have been observed in patients with essential hypertension, myocardial infarction as well as at ageing (36)(37)(38)(39). Moreover, such diseases as essential hypertension (40), brady arrhythmias (41), cardiomyopathy (42, 43, 44) and atherosclerosis (45,46) as well as aging are accompanied with elevated kynurenine and lor neopterin concentrations in the blood. So the results of this study on lipid metabolism, as well as on kynurenine and neopterin concentrations extend and agree well with the data of the literature.…”

Section: Pteridineslvol 11 Rnomentioning

confidence: 99%

Impairment of Lipid Metabolism Due to Deficiency of Pyridoxal-5-phosphate and/or Activated Immune system: its Interpretation

Rudzite¹,

Jurika²,

Jäger

et al. 2000

Pteridines

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Impairment of lipid metabolism due to excess metabolite accumulation induced by pyridoxal-5-phosphate (P-5-P)-deficiency andlor stimulated immune system has been studied and interpreted. Decreased amounts of phospholipids as well as deviations in phospholipid classes and fatty acid composition of phospholipids have been demonstrated due to kynurenine accumulation in the blood of P-5-P-deficient cardiovascular patients and white rats as well as in cardiovascular patients with activated immune system identified by an increased neopterin concentration in the blood (dilated cardiomyopathy) . The addition of P-5-P to the incubation medium for phospholipid biosynthesis in vitro did not change fatty acid incorporation into phospholipids, whereas it normalised fatty acid incorporation into phospholipids in liYer homogenates recei,·ed from P-5-P-deficient rats: 'Ine addition of kynurenine, neopterin and noradrenalin (accumulated m isolated heart tissue after addition of kynurenine and neopterin to incubation medium for isolated heart) to incubation medium for phospholipid biosynthesis in vitro induced an increase of saturated and a decrease of polyunsaturated fatty acid incorporation into phospholipids. These changes in fatty acid incorporation into phospholipids were followed by increased cholesterol concentrations in samples and an increased cholesterol/phospholipid ratio. Our results suggest that these changes in lipids are characteristic for decreased membrane fluidity, depressed cell cycle and lowered possibility of phospholipids to keep cholesterol in solution. P-5-P-deficiency is also accompanied with excess accumulation of homocysteine in the blood. The addition of L-homocysteine to the incubation medium for phospholipid biosynthesis in vitro was followed by inverse changes in fatty acid incorporation into phospholipids when compared with kynurenine , neopterin and noradrenalin. L-homocysteine induced a decrease of saturated and an increase of polyunsaturated fatty acid incorporation into phospholipids. The cholesterol concentration decreased in samples and the cholesterol/phospholipid ratio decreased, too . These findings suggest that changes in lipids induced by L-homocysteine are characteristic for increased membrane fluidity and stimulated cell cycle. In this study, we have observed a similar effect to L-homocysteine effect when L-homocysteine, L-tryptophan and 5,6,7,8-tetrahydrobiopterin were added to the incubation medium for phospholipid biosynthesis in vitro. The comparison of our results with data from the literature allows to suggest that excess metabolite accumulation due to activated formation and inactivated catabolism of it plays a significant role in quantitative and qualitative changes of lipids, especially phospholipids, and therefore participates in the regulation of membrane fluidity, cell cycle of normal and malignant cells as well as in keeping cholesterol in the state of solution.

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Elevated serum neopterin levels in atherosclerosis

Cited by 116 publications

References 17 publications

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Systemic Inflammatory Parameters in Patients With Atherosclerosis of the Coronary and Peripheral Arteries

Neopterin as a biomarker of immune response in cancer patients

Impairment of Lipid Metabolism Due to Deficiency of Pyridoxal-5-phosphate and/or Activated Immune system: its Interpretation

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