Elevated Serum Midkine in Patients With Acute Pancreatitis

Li, Yao; Lu, Yongda; Shen, Jiaqing; Xu, Chunfang

doi:10.1016/j.amjms.2017.07.010

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Local complications were comprised of acute peripancreatic fluid collection, pancreatic pseudocyst, acute necrotic collection, walled‐off necrosis, gastric outlet dysfunction, splenic and portal vein thrombosis, and colonic necrosis …”

Section: Methodsmentioning

confidence: 99%

“…Organ failure was considered to exist when one of the following manifestations occurred: (a) shock (systolic pressure < 90 mm Hg); (b) pulmonary insufficiency (PaO 2 ≤ 60 mm Hg); (c) renal failure (serum creatinine > 2.0 mg/dL after hydration); (d) gastrointestinal bleeding (>500 mL/24 h); (e) disseminated intravascular coagulation (platelets ≤ 100 000/mm 3 , fibrinogen ≤ 100 mg/dL, and fibrin split products > 80 mg/mL); (f) a severe metabolic disturbance (serum calcium ≤ 7.5 mg/dL); and (g) the presence of SIRS, which was defined by presence of two or more following criteria: (a) heart rate > 90 beats/min, (b) core temperature < 36 or >38°C, (c) white blood count < 4000 or >12 000/mm 3 , and (d) respirations > 20/min …”

Section: Methodsmentioning

confidence: 99%

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The early predictive role of complement C3 and C4 in patients with acute pancreatitis

Zhang

Qiao

Huang

et al. 2020

Clinical Laboratory Analysis

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Acute pancreatitis (AP) is a common disease in the department of gastroenterology. The main etiologies of AP are biliary tract diseases, alcohol over-consumption, and hyperlipidemia. 1 Most of AP patients involve regional inflammation and/or necrosis of the pancreas which will result in the discharge of a variety of inflammatory mediators. However, a small proportion of patients will suffer from the systemic inflammatory reaction caused by the over-production of these inflammatory mediators. 2 For those patients, which are thought as severe AP (SAP), systemic inflammatory response syndrome and various organ dysfunctions are finally induced secondary to the pancreatic damage. 3 In SAP, high morbidity and mortality are often observed clinically. 4,5 Thus, the early and effective assessment of severe cases is still of urgency and benefits the early interventions. AbstractObjective: The prognostic role of complement C3 and C4 in peripheral blood in early stage of acute pancreatitis (AP) is unknown. In this study, we aimed to evaluate the prognostic value of C3 and C4 in early stage of AP. Methods:A total of 164 patients were enrolled in this study. The blood samples were collected within 24 hours after AP onset. We compared C3 and C4 levels in patients with different AP severity. The optimal cutoff value for them to predict severe AP (SAP) was determined by receiver operating characteristic (ROC) curve analysis. Results:The reduction of C3 and C4 levels was observed. For prediction of MSAP and SAP, the AUC of C3 and C4 levels was 0.695 (95% CI: 0.612-0.779) and 0.739 (95% CI: 0.657-0.821). The cutoff value of C3 and C4 levels was 0.705 and 0.145 g/L, with the sensitivity of 0.612 and 0.735, and the specificity of 0.735 and 0.710. For prediction of SAP, the AUC of C3 and C4 levels was 0.749 (95% CI: 0.607-0.891) and 0.766 (95% CI: 0.596-0.936). The cutoff value of C3 and C4 levels was 0.400 and 0.125 g/L, with the sensitivity of 0.859 and 0.767, and the specificity of 0.600 and 0.786. Conclusions:A marked change of complement C3 and C4 was observed in peripheral blood of patients with AP, suggesting the participation of complement system in the early phase of AP. C3 and C4 levels were sensitive and accurate in judging the severity of AP. K E Y W O R D Sacute pancreatitis, complement C3 and C4, peripheral blood, prediction, severityThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The early predictive role of complement C3 and C4 in patients with acute pancreatitis

Zhang

Qiao

Huang

et al. 2020

Clinical Laboratory Analysis

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Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis

Bálint

Für

Kiss

et al. 2020

Sci Rep

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The main causes of acute pancreatitis (AP) are biliary disease, alcohol consumption, hypertriglyceridaemia (HTG) and endoscopic retrograde cholangiopancreatography (ERCP). The aim of this meta-analysis was to evaluate the effects of these aetiological factors on the severity and outcome of AP. Pubmed and Embase were searched between 01/01/2012 and 31/05/2020. Included articles involved adult alcoholic, biliary, HTG- or post-ERCP AP (PAP) patients. Primary outcome was severity, secondary outcomes were organ failures, intensive care unit admission, recurrence rate, pancreatic necrosis, mortality, length of hospital stay, pseudocyst, fluid collection and systematic inflammatory response syndrome. Data were analysed from 127 eligible studies. The risk for non-mild (moderately severe and severe) condition was the highest in HTG-induced AP (HTG-AP) followed by alcoholic AP (AAP), biliary AP (BAP) and PAP. Recurrence rate was significantly lower among BAP vs. HTG-AP or AAP patients (OR = 2.69 and 2.98, 95% CI 1.55–4.65 and 2.22–4.01, respectively). Mortality rate was significantly greater in HTG-AP vs. AAP or BAP (OR = 1.72 and 1.50, 95% CI 1.04–2.84 and 0.96–2.35, respectively), pancreatic necrosis occurred more frequently in AAP than BAP patients (OR = 1.58, 95% CI 1.08–2.30). Overall, there is a potential association between aetiology and the development and course of AP. HTG-AP is associated with the highest number of complications. Furthermore, AAP is likely to be more severe than BAP or PAP. Greater emphasis should be placed on determining aetiology on admission.

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Elevated Serum Midkine in Patients With Acute Pancreatitis

Cited by 2 publications

References 27 publications

The early predictive role of complement C3 and C4 in patients with acute pancreatitis

The early predictive role of complement C3 and C4 in patients with acute pancreatitis

Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis

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