Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behçet's disease and its association with disease activity and quality of life

Oktayoğlu, Pelin; Mete, Nuriye; Çağlayan, Mehmet Gökhan; Bozkurt, Mehtap; Bozan, Turgut; Em, Serda; Nas, Kemal

doi:10.3109/00365513.2014.984319

Cited by 22 publications

(17 citation statements)

References 46 publications

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“…In a study in which serum calprotectin level was analyzed in BD, calprotectin serum levels were found to be significantly higher in cases with BD compared to healthy controls; however serum calprotectin levels demonstrated no correlation with BD activity in that study [6]. …”

Section: Discussionmentioning

confidence: 99%

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The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet’s Disease

et al. 2016

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One of the regions of involvement of Behçet's disease (BD), a systematic inflammatory vasculitis with unknown etiology, is the gastrointestinal (GI) tract. Upper GI endoscopy, colonoscopy, and capsule endoscopy are frequently used methods to diagnose the intestinal involvement of BD. The aim of this study was to investigate the role of fecal calprotectin (FC) in the evaluation of intestinal involvement in BD. Material and Method. A total of 30 patients who were diagnosed with BD and had no GI symptoms and 25 individuals in the control group were included in this study. Results. Levels of FC were statistically significantly higher in patients with BD compared to the control group (p < 0.001). The correlation analysis performed including FC and markers of disease activity revealed a positive and statistically significant correlation between FC level and CRP and erythrocyte sedimentation rate (r: 0.255, p < 0.049, and r: 0.404, p < 0.001, resp.). FC levels in patients who were detected to have ulcers in the terminal ileum and colon in the colonoscopic examination were statistically significantly higher compared to the patients with BD without intestinal involvement (p = 0.01). Conclusion. The measurement of FC levels, in patients with BD who are asymptomatic for GI involvement, may be helpful to detect the possible underlying intestinal involvement.

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Section: Discussionmentioning

confidence: 99%

“…FC becomes evident during cell activation or death. We encountered a very low number of studies investigating the level of FC in BD in the literature review we performed [6]. The aim of this study was to investigate the role of FC in the evaluation of intestinal involvement in BD.…”

Section: Introductionmentioning

confidence: 99%

The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet’s Disease

et al. 2016

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Section: Behç Et's Diseasementioning

confidence: 99%

“…152 CLP was also tested as a disease biomarker, but no correlations were found with disease activity scores or quality of life indices in BD patients. 152 Uveitis and oral aphthous ulcerations might be potential sources of S100A8 and S100A9 production in BD. In fact, raised CLP serum levels have been found in patients with uveitis [153][154][155] and it has been shown that mucosal squamous epithelial cells can express CLP under inflammatory conditions.…”

Section: Behç Et's Diseasementioning

confidence: 99%

Calprotectin in rheumatic diseases

Ometto

Friso

Astorri

et al. 2016

Exp Biol Med (Maywood)

136

105

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Calprotectin is an acute-phase protein produced by monocytes and neutrophils in the circulation and inflamed tissues. Calprotectin seems to be more sensitive than CRP, being able to detect minimal residual inflammation and is a candidate biomarker in inflammatory diseases. High serum levels are associated with some severe manifestations of rheumatic diseases, such as glomerulonephritis and lung fibrosis. Calprotectin levels in other fluids, such as saliva and synovial fluid, might be helpful in the diagnosis of rheumatic diseases. Of interest is also the potential role of calprotectin as a target of treatment. AbstractCalprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are mainly produced by activated monocytes and neutrophils in the circulation and in inflamed tissues. The implication of calprotectin in the inflammatory process has already been demonstrated, but its role in the pathogenesis, diagnosis, and monitoring of rheumatic diseases has gained great attention in recent years. Calprotectin, being stable at room temperature, is a candidate biomarker for the follow-up of disease activity in many autoimmune disorders, where it can predict response to treatment or disease relapse. There is evidence that a number of immunomodulators, including TNF-a inhibitors, may reduce calprotectin expression. S100A8 and S100A9 have a potential role as a target of treatment in murine models of autoimmune disorders, since the direct or indirect blockade of these proteins results in amelioration of the disease process. In this review, we will go over the biologic functions of calprotectin which might be involved in the etiology of rheumatic disorders. We will also report evidence of its potential use as a disease biomarker.

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“…Calprotectin (MRP8/MRP14) is expressed by activated phagocytes, granulocytes, monocytes, and vascular endothelial cells; is recognized by tolllike receptors; and induces a thrombogenic and inflammatory response in human microvascular endothelial cells. Serum levels of calprotectin were significantly higher in patients with Behçet's disease compared with healthy controls [23]. Ischaemia-modified albumin (IMA) is a sensitive biomarker of ischaemia and oxidative stress.…”

Section: The Relation Between Vascular Involvement and Endothelial Dymentioning

confidence: 99%

Behçet's disease and risk of vascular events

Balta

Öztürk

et al. 2016

Current Opinion in Cardiology

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Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behçet's disease and its association with disease activity and quality of life

Abstract: Calprotectin may play a significant role in the pathogenetic mechanisms of BD. Further insight into this area of research might provide opportunities to develop novel treatment strategies.

Cited by 22 publications

References 46 publications

The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet’s Disease

The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet’s Disease

Calprotectin in rheumatic diseases

Behçet's disease and risk of vascular events

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