Elevated Serum Leptin Levels: A Risk Factor for Non-Small-Cell Lung Cancer?

Abstract

Objective: Leptin is intimately intertwined in the molecular pathophysiology of several cancer types; with regard to lung cancer, however, limited research has been conducted, with overall conflicting results. Methods: The present case-control study comprises 66 non-small-cell lung cancer (NSCLC) cases and 132 healthy controls matched for gender and age. Lifestyle, sociodemographic and medical history information has been obtained in addition to body mass index (BMI) measurements and weight change during the last 2 months. Serum leptin and adiponectin levels were determined following a standard protocol. Results: In multiple logistic regression analyses, elevated serum leptin emerged as a risk factor for NSCLC independent of central obesity, more pronounced after controlling for BMI and recent weight loss (odds ratio = 4.58, 95% confidence interval: 1.94–10.82). Additionally, smoking and animal foods consumption were strongly associated with the disease, whereas plant foods consumption showed a protective association. Conclusions: The observed higher serum leptin levels in NSCLC cases might be attributed to direct or indirect effects mediated by cancer- or cachexia-related cytokines. In line with the growth-promoting properties of leptin in the lung tissue documented elsewhere, increased serum leptin concentration may represent a tumor-promoting event during non-small-cell lung carcinogenesis.

Prospective cohort study on television viewing time and incidence of lung cancer: findings from the Japan Collaborative Cohort Study

“…We also included variables 1 such as daily dietary consumption of green leafy vegetables (1-2 times/month or less, 2 1-2 times/week or less, 3-4 times/week or more, unknown), oranges (1-2 times/month 3 or less, 1-2 times/week or less, 3-4 times/week or more, unknown), and fruits other than 4 oranges (1-2 times/month or less, 1-2 times/week or less, 3-4 times/week or more, 5 unknown) in the multivariate models because these variables were known to be 6 associated with a reduction in lung cancer mortality [5]. However, we did not include 7 daily walking time because it did not make a meaningful contribution to the model.…”

Malign Plevral Efüzyonlarda Leptin: Yeni Bir Markır Olabilir mi?

“…Bu çalışmalarda leptinin serum düzeylerinde yükseklik bulunmuştur. Yapılan bir çalışmada 66 küçük hücreli dışı akciğer kanserli hastada ve 132 sağlıklı gönüllünün serum leptin düzeyleri karşılaştırılmış ve serum leptin düzeyinin küçük hücreli dışı akciğer kanseri için bağımsız bir risk faktörü olabileceği vurgulanmıştır (27). Diğer bir çalışmada ise 140 hasta ve 342 sağlıklı gönüllüde leptin geni olarak tanımlanmış LEP-2548 G/A polimorfizmi incelenmiş ve AA taşıyıcılı kişilerin akciğer kanseri gelişimi açısından riskli olabileceği, bu riskin sigara içimi ile arttığı bildirilmiştir (28).…”

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

“…Clinically stable emphysematous COPD patients exhibit low leptin levels compared with the chronic bronchitis subtype 159. During acute flare ups, these plasma levels rise temporarily,189 as seen in NSCLC 209, 210. Likewise, enhanced plasma ghrelin levels are noticed in COPD211 and NSCLC212 and are related to cachectic status.…”