Elevated serum copper levels in women with a history of post-partum depression

Crayton, John W.; Walsh, William J.

doi:10.1016/j.jtemb.2006.10.001

Cited by 65 publications

(32 citation statements)

References 22 publications

(25 reference statements)

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“…High Cu concentration is observed in Alzheimer’s, Parkinson’s, and Wilson’s diseases and may also lead to decline in intelligence in young adolescents [8, 9]. Limited data also suggests the potential importance of copper in the development of neuropsychiatric disorders, including depression [6, 11–16], and several compelling arguments can confirm this fact.…”

Section: Introductionmentioning

confidence: 99%

Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Styczeń

Sowa-Kućma

Siwek

et al. 2016

Biol Trace Elem Res

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Copper may be involved in the pathophysiology of depression. Clinical data on this issue are very limited and not conclusive. The purpose of the study was to determine the copper concentration in the serum of patients with major depressive disorder and to discuss its potential clinical usefulness as a biomarker of the disease. A case–control clinical study included 69 patients with current depressive episode, 45 patients in remission and 50 healthy volunteers. Cu concentration was measured by electrothermal atomic absorption spectrometry (ETAAS). The mean serum copper level in depressed patients was slightly lower (by 11 %; not statistically significant) than in the control group. Furthermore, there was no significant difference in Cu2+ concentration between depressive episode and remission, nor between remission and control group. In the remission group were observed significant correlations between copper levels and the average number of relapses over the past years or time of remission. There was no correlation between serum copper and severity of depression, as measured by HDRS and MADRS. The obtained results showed no significant differences between the copper concentration in the blood serum of patients (both with current depressive episode and in remission) and healthy volunteers, as well as the lack of correlations between the copper level in the active stage of the disease and clinical features of the population. Our study is the first conducted on such a large population of patients, so the results may be particularly important and reliable source of knowledge about the potential role of copper in depression.

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Section: Introductionmentioning

confidence: 99%

Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Styczeń

Sowa-Kućma

Siwek

et al. 2016

Biol Trace Elem Res

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“…Moreover, persistently high copper levels may contribute to postpartum depression due to the effects of metals on nervous tissue. Excess copper in the brain, can alter the balance of dopamine and norepinephrine, two mood-regulating neurotransmitters 15 .…”

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confidence: 99%

Serum Copper and Plasma Protein Status in Normal Pregnancy

Noor¹,

Jahan

Sultana³

2013

J Bangladesh Soc Physiol

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Background: Gradual alteration of serum copper and some plasma protein levels may occur with advancement of pregnancy, which is associated with increased maternal and infant morbidity and mortality. Objective: To observe serum copper and plasma protein levels in normal pregnant women of different trimesters in order to find out their nutritional status. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka, between 1 st January 2010 and December 2010. Ninety normal pregnant women of different trimesters with age 20-30 years were included in the study group. They were selected from Out Patient Department of Obstetrics and Gynaecology, SSMC. Age matched 30 non-pregnant women were taken as control. Serum copper level was measured by Spectrophotometric method, serum total protein and albumin levels were estimated by standard method. Statistical analysis was done by one way ANOVA, Bonferroni and Pearson's correlation coefficient test as applicable. Results: Serum Cu levels were significantly higher in all trimesters of pregnant women compared to control. Again, this value was significantly higher in 3 rd trimester than that of in 1 st and 2 nd trimester and also in 2 nd trimester than that of in 1 st trimester. In addition, mean serum total protein level was significantly lower in 3 rd trimester than control but no statistically significant difference was observed among different trimesters. Again, mean serum albumin level was significantly lower in 2 nd and 3 rd trimester than 1 st trimester and control. In addition, serum Cu concentration showed significant positive correlation with different trimesters of gestation. Conclusion: This study reveals that hypercupremia along with hypoproteinemia occur in pregnant women from 1 st to 3 rd trimester of gestation. This gradual alteration of micro and macronutrients become more profound with advancement of pregnancy.

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“…These findings are consistent with ours in that no relationship was observed between depression and serum zinc level. In addition, there was no statistically significant difference in serum zinc level between depressed and non-depressed men; moreover, copper level was higher in depressed women than depressed men (Crayton & Walsh, 2007).…”

Section: Discussionmentioning

confidence: 67%

“…Moreover, some studies have suggested that zinc and magnesium serum level in depressive patients, especially those with PPD, is lower than non-depressed individuals (DiGirolamo & Ramirez-Zea, 2009;Stanislawska et al, 2014;Swardfager et al, 2013). However, some other studies have not suggested any statistically significant relationship between the zinc and magnesium serum levels with depression (Crayton & Walsh, 2007;Islam et al, 2013). The anti-depression feature of zinc and magnesium has been seen in animal studies, including on mice (Kroczka et al, 2001;Mlyniec et al, 2013;Samardzic et al, 2013;Poleszak et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran

Edalati-Fard¹,

Mirghafourvand²,

Mohammad‐Alizadeh‐Charandabi³

et al. 2016

GJHS

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Objective: According to the World Health Organization, depression will be the second prevalent problem after ischemic heart diseases by the year 2020. Postpartum depression (PPD) as a major depressive episode has devastating impacts on the health of mother, newborn, infant, and even the whole family. This study was conducted to investigate the relationship of zinc and magnesium serum levels with PPD, as one of the commonly assumed causes of depression. Methods:This cross-sectional study was done on 122 postpartum women aged 18 years and more in two educational hospitals and one non-educational hospital in Tabriz-Iran, 2015. The eligible women were selected using convenience sampling method. Then, the demographic characteristics questionnaire and Edinburgh Depression Scale were completed by participants, and 5cc of blood sample was drawn from each participant. For data analysis, logistic regression test was used. Results:The mean score of depression scale was 8.0 (SD: 4.7), meaning that 18.9% of mothers were depressed. Results indicated a significant inverse correlation between Edinburgh depression score and magnesium serum level (p= 0.001). However, there was no statistically significant relationship between the zinc serum level and Edinburgh depression score (p=0.831), in so far as based on logistic regression analysis, increased magnesium serum level decreased the odds of depression [Odds ratio: 0.05; CI 95%: 0.01 to 0.29].Conclusions: In this study, there was a significant inverse relationship between magnesium serum level and Edinburgh depression score.

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Elevated serum copper levels in women with a history of post-partum depression

Cited by 65 publications

References 22 publications

Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Serum Copper and Plasma Protein Status in Normal Pregnancy

Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran

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