Elevated serum CA 19-9 in hepatic actinomycosis

Soardo, Giorgio; Basan, Lorenza; Intini, S; Avellini, Claudio; Sechi, Leonardo A.

doi:10.1080/00365520510024232

Cited by 9 publications

(6 citation statements)

References 5 publications

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“…With these types of benign conditions the elevation of CA19-9 is often lower than malignant conditions. At a level of 1000 U/ml the marker's positive predictive value approaches 100% [8]. In our patient the CA19-9 level was 49.6 U/ml, which may have been an indication that her presenting symptoms were not secondary to a malignant process.…”

Section: Discussionmentioning

confidence: 63%

“…CA19-9 is a carbohydrate epitope that is sialylated on the surface of certain tumors. It is not organ specific and is clinically used as a marker of pancreatic, hepatobiliary and gastric malignancies [8]. This marker is often elevated in benign disease states of the hepatobiliary system, renal failure, pleural effusion, intestinal pneumonia and systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

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Isolated hepatic actinomycosis: a case report

2010

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IntroductionActinomyces are slow growing, non-spore forming, gram-positive, branching bacilli that thrive in anaerobic and microareophilic conditions. Actinomyces are more commonly associated with oral and cervicofacial infections. Hepatic involvement in infections of the abdomen (known as isolated hepatic actinomycosis) is rare, accounting for only 5% of all cases of actinomycosis.Case presentationWe present the case of a 75-year-old Caucasian woman with a 3-month history of night sweats, fever, chills, abdominal bloating, anorexia, weight-loss, and early satiety. The patient was found to have isolated hepatic actinomycosis infection after undergoing a laparotomy with a biopsy of the liver. The patient has now recovered.ConclusionIsolated hepatic actinomycosis is a rare and often overlooked etiology for a liver mass. Given its subacute presentation and nondescript symptomatology, physicians should be aware of this differential and the potential pitfalls in diagnosis and management.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Isolated hepatic actinomycosis: a case report

2010

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“…Anemia, leukocytosis, ESR and CRP elevations, and prolongation of PT and activated partial thromboplastin time may be present in actinomycosis. Additionally, it may elevate serum levels of CA 19-9 [3] .…”

Section: Resultsmentioning

confidence: 99%

“…A yellowish vaginal discharge with foul odor was present on speculum examination. Laboratory data were notable for a white blood cell count of 12,610 cells/mm 3 (4,000-10,000 cells/mm 3 ), hemoglobin of 9.3 g/dl (12.0-16.0 g/dl), erythrocyte sedimentation rate (ESR) 101 mm/h (0-20 mm/h), C-reactive protein (CRP) 8.34 mg/dl (0-1.0 mg/dl), and prothrombin time (PT), r -glutamyl transpeptidase ( r -GTP), alkaline phosphatase (ALP) values of 1.26 INR (0.8-1.2 INR), 76 IU/l (8-35 IU/l), and 136 IU/l (30-115 IU/l), respectively. Relevant tumor markers did not exceed accepted normal ranges, i.e., alpha fetoprotein ( ␣ FP) 5 ng/ml, carcinoembryonic antigen (CEA) 1.1 ng/ml, carbohydrate antigen 19-9 (CA 19-9) 5 U/ml, cancer antigen 125 (CA 125) 16 U/ml, beta human chorionic gonadotropin ( ␤ -hCG) 4 mIU/ml.…”

Section: Introductionmentioning

confidence: 99%

A Case of Pelvic Actinomycosis with Hepatic Actinomycotic Pseudotumor

Kim¹,

Park²,

Park³

et al. 2007

Gynecol Obstet Invest

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Pelvic actinomycosis in women most commonly occurs during ascending infections, usually associated with intrauterine devices (IUDs). However, secondary hepatic actinomycosis is very rare. A 47-year-old woman using IUDs for 18 years was referred under the impression of ovarian cancer. Further investigation revealed a hepatic tumor diagnosed as an inflammatory pseudotumor by fine needle aspiration biopsy, and a pelvic mass diagnosed as pelvic actinomycosis by sulfur granules in bilateral adnexa gained by an explorative laparotomy. Long-term therapy with high-dose intravenous penicillin and oral amoxicillin resulted in clinical and radiological improvement. The management of pelvic actinomycosis is based on a medical approach, although it sometimes requires surgical intervention. However, the necessity for surgical treatment is controversial in cases of secondary hepatic actinomycosis.

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“…The CA19-9 level is often elevated in benign diseases of the hepatobiliary system, renal failure, pleural effusion, intestinal pneumonia, and systemic lupus erythematosus. However, the level of elevation in these benign conditions is often lower than that in malignant conditions [9,10]. Despite these benefits, CA19-9 has inadequate sensitivity and specificity to be used as a marker for differentiating hepatic actinomycosis from liver tumors [11,12].…”

Section: Discussionmentioning

confidence: 99%

The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report

Guo

Gong

et al. 2013

J Med Case Reports

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IntroductionPrimary hepatic actinomycosis is a rare disease, but is important in the differential diagnosis of hepatoma in endemic areas. As high mobility group box chromosomal protein 1 plays an important role in the pathogenesis of both acute and chronic inflammatory conditions, we postulate that high mobility group box chromosomal protein 1 may have a possible pathogenic role in hepatic actinomycosis. To the best of our knowledge, our report is the first to detect an association between highly elevated high mobility group box chromosomal protein 1 expression and hepatic actinomycosis.Case presentationA 67-year-old Chinese man was admitted to our hospital with a three-month history of epigastric pain, anorexia, and subjective weight loss. Ultrasonography and computed tomography of the patient’s abdomen confirmed a hypodense mass measuring seven cm in diameter in the left lateral segment of his liver. A hepatic tumor was suspected and surgical resection was scheduled. Histopathologic examination revealed that the overall features of the hepatic tissues were consistent with hepatic actinomycosis. Whole blood and hepatic tissue samples of the patient, of patients who had hepatocellular carcinoma and of healthy donors were collected. Serum high mobility group box chromosomal protein 1 concentration in actinomycosis was 8.5ng/mL, which was higher than the hepatocellular carcinoma level of 5.2ng/mL and the normal level of

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Elevated serum CA 19-9 in hepatic actinomycosis

Cited by 9 publications

References 5 publications

Isolated hepatic actinomycosis: a case report

Isolated hepatic actinomycosis: a case report

A Case of Pelvic Actinomycosis with Hepatic Actinomycotic Pseudotumor

The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report

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