Elevated Serum Arginase Activity Levels in Patients with Breast Cancer

Polat, Murat; Taysı, Seyithan; Polat, Sevinç; Böyük, Abdullah; Bakan, Ebubekîr

doi:10.1007/s00595-002-2563-2

Cited by 63 publications

(48 citation statements)

References 20 publications

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“…The present results imply that both NOS, which converts arginine to citrulline, and arginase, which converts arginine to ornithine, may be elevated in CS patients. The implication of higher arginase activity in CS is consistent with reports of arginase induction by inflammatory cytokines known to be elevated in cardiac ischemia-reperfusion injury and CS 28 and extends reports of increased arginase activity in a number of disease states, including MI, 29 asthma, 30 breast cancer, 31 and pulmonary hypertension. 22,32 NO also can be produced in large and potentially toxic amounts by iNOS expressed in response to trauma and inflammatory stimuli.…”

Section: Discussionsupporting

confidence: 88%

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

et al. 2007

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Background-It is unclear whether abnormalities of arginine and nitric oxide metabolism are related to hemodynamic dysfunction and mortality in patients with cardiogenic shock (CS) after acute myocardial infarction. Methods and Results-Plasma metabolites reflecting arginine bioavailability, nitric oxide metabolism, and protein oxidation were analyzed by mass spectrometry in patients with CS (nϭ79) and age-and gender-matched patients with coronary artery disease and normal left ventricular function (nϭ79). CS patients had higher levels of asymmetric dimethylarginine (ADMA; PϽ0.0001), symmetric dimethylarginine (PϽ0.0001), monomethylarginine (Pϭ0.0003), nitrotyrosine (PϽ0.0001), and bromotyrosine (PϽ0.0001) and lower levels of arginine (PϽ0.0001), ratio of arginine to ornithine (Pϭ0.03), and ratio of arginine to ornithine plus citrulline) (Pϭ0.0003). CS patients with elevated ADMA levels were 3.5-fold (95% confidence interval, 1.4 to 11.3; Pϭ0.02) more likely to die in 30 days than patients with low ADMA levels. ADMA remained the only independent predictor of mortality on multiple logistic regression analysis. In patients with normal renal function, symmetric dimethylarginine levels inversely correlated with mean arterial pressure and systemic vascular resistance, whereas levels of ADMA correlated with pulmonary capillary wedge pressure and both systolic and diastolic pulmonary artery pressures. Despite dramatic elevations, levels of protein oxidation products did not predict hemodynamic dysfunction or mortality in CS patients. Conclusions-CS is characterized by an arginine-deficient and highly specific pro-oxidant state, with elevated levels of methylated arginine derivatives, including endogenous nitric oxide synthase inhibitors. Levels of methylated arginine derivatives strongly correlate with hemodynamic dysfunction. Among all clinical and laboratory parameters monitored, ADMA levels were the strongest independent predictor of 30-day mortality.

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Section: Discussionsupporting

confidence: 88%

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

et al. 2007

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“…While playing roles in amino acid metabolism, increased ARG1 expression is reported in patients with advanced cancer, including hepatocellular carcinoma, renal cell carcinoma and breast cancer (77)(78)(79)(80)(81). A study in preclinical murine models has also shown that inhibition of ARG1 in the skin is associated with increased inflammation and defects in matrix deposition (82).…”

Section: Discussionmentioning

confidence: 99%

In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue

Azimi

Kaufman

Ali

et al. 2016

CGP

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“…Perioperative arginine-enriched nutrition significantly improved the long-term overall survival and long-term disease-specific survival in malnourished patients with head and neck cancer (Buijs et al, 2010). Higher expression and activity of ARG1 are often observed in the blood of cancer patients (Polat et al, 2003;Grabon et al, 2009;Rodriguez et al, 2009). After surgical removal of malignant tumors, remnant cells can proliferate.…”

Section: Discussionmentioning

confidence: 99%

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

Srivastava

Ghosh²

2015

Asian Pacific Journal of Cancer Prevention

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Background: Arginine may play important roles in tumor progression by providing ornithine for polyamine biosynthesis, required for cell growth. The aim of this work was to determine the expression of arginine metabolic pathway enzymes in head and neck squamous cell carcinoma (HNSCC) in northeast India. Materials and Methods: The expressions of arginase isoforms (ARG1 and ARG2), ornithine aminotransferase (OAT) and ornithine decarboxylase (ODC) were examined in fifty paired HNSCC and adjacent non-tumor tissues by immunohistochemistry. Immunocytochemistry, semiquantitative reverse transcription sq-PCR and quantitative real-time qPCR were used to assess protein and mRNA expressions in peripheral blood of fifty HNSCC patients and hundred controls. Results: ARG1 and ODC protein and mRNA were strongly expressed in peripheral blood from HNSCC patients. No ARG2 expression was observed. In vivo, expression of ARG1, ARG2 and ODC was significantly higher in tumor than in non-tumor tissues. Most tumors expressed low levels of OAT, with no difference in tissues or blood, compared to controls. The absolute extent of maximal ARG1 upregulation with qPCR showed 6.23 fold increase in HNSCC. Conclusions: These findings strongly suggest that in HNSCCs, the ARG1 pathway is stimulated leading to the formation of polyamines as indicated by higher ODC expression, which promote tumor growth.

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Elevated Serum Arginase Activity Levels in Patients with Breast Cancer

Cited by 63 publications

References 20 publications

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue

Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India

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