Elevated Serum Amylase Associated with Bronchogenic Carcinoma: Report of Case

Weiss, Murray J.; Edmondson, Hugh A.; Wertman, Maxine

doi:10.1093/ajcp/21.11.1057

Cited by 72 publications

(23 citation statements)

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“…Hyperamylasaemia resulting from the ectopic production of amylase by tumor tissue was first described 54 years ago by Weiss et al [1] in a patient with lung cancer. Subsequently, hyperamylasaemia has been reported in a number of epithelial tumors including ovarian [2], endometrial [3], gastric [4] and breast [5] cancer.…”

Section: Introductionmentioning

confidence: 97%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

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This study reports a case of a patient with lambda-light chain multiple myeloma who developed a high hyperamylasaemia of the salivary type during the disease and soon afterwards died. Ectopic production of amylase by myeloma cells has been described in a few cases and demonstrated by tissue culture and immunohistochemical techniques. The common characteristics of these cases were: salivary amylase isoenzyme increase, high tumor mass, extensive extra-medullary spread, extensive bone destruction and poor prognosis. In patients with amylase-producing multiple myeloma, the onset of hyperamylasaemia heralds a rapid disease progression; therefore, in these patients, a simple test such as serum amylase may represent a reliable disease activity index and provide an additional prognostic information.

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Section: Introductionmentioning

confidence: 97%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

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“…Paraneoplastic production of amylase activity is an un common phenomenon described in tumors of lung, ovary, breast, uterus, stomach and bone [1][2][3][4][5][6]. Ectopic amylase production is even rarer, with only 8 patients with multiple myeloma (MM) [7][8][9][10] and 1 more with monoclonal gammapathy of undetermined significance [11 ] being reported.…”

Section: Introductionmentioning

confidence: 99%

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

López

Ulibarrena²,

González-Porqué³

et al. 1993

Acta Haematol

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Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a possible pancreatitis made us suspect the diagnosis. Amylase production was observed in bone marrow cultures in which 96% of cellularity was composed of plasmablasts. Serum amylase level decreased when chemotherapy was given.

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“…The association between hyperamylasemia and lung cancer was fi rst reported by Weiss et al 1 Amylase-producing lung cancer is a relatively rare disease, comprising 1% to 3% of all lung cancers. The major histologic type of amylase-producing lung cancer is adenocarcinoma.…”

Section: Introductionmentioning

confidence: 91%

Serum amylase is a sensitive tumor marker for amylase-producing small cell lung cancer?

et al. 2007

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A 68-year-old male smoker was diagnosed as having amylase-producing small-cell lung cancer (SCLC). The serum amylase level was elevated, at 1756 IU/l, and the isozyme pattern was salivary type. Serum levels of "the tumor markers" CEA and NSE were 10.0 ng/ml and 22.6 ng/ml, respectively, but the level of pro-GRP was within the normal range. He was treated with combination chemotherapy of carboplatin and irinotecan. After completion of the chemotherapy, the serum amylase level decreased below the cutoff range and a computed tomography (CT) scan of the chest revealed marked reductions of the tumor in the primary site and in the lymph node metastasis. In November 2003, he was noted to have a slightly raised amylase level, of 168 IU/l, and raised levels of tumor markers. At this time, a CT scan, bone scintigraphy, and magnetic resonance imaging (MRI) of the brain demonstrated no recurrence. However, in December, MRI of the brain showed multiple metastases, and the recurrence of SCLC was thus confirmed. For the treatment of disease progression, the same regimen of chemotherapy as that given initially was administered. CT imaging revealed a partial response in the primary site and lymph node metastasis, and the serum amylase level decreased to 91 IU/l. After the completion of the second chemotherapy regimen, he underwent cranial irradiation and further chemotherapy. However, unfortunately, he died owing to deterioration of lung cancer. In this patient, the serum amylase level was found to be a highly sensitive marker of lung cancer.

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Elevated Serum Amylase Associated with Bronchogenic Carcinoma: Report of Case

Cited by 72 publications

References 0 publications

Amylase: A disease activity index in multiple myeloma?

Amylase: A disease activity index in multiple myeloma?

Amylase-Producing Bence Jones Multiple Myeloma with Pancreatitis-Like Symptoms

Serum amylase is a sensitive tumor marker for amylase-producing small cell lung cancer?

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