Elevated SCF levels in the serum of patients with chronic renal failure

Kitoh, Takashi; Ishikawa, Hitoshi; Ishii, Tatsuo; Nakagawa, Shigeki

doi:10.1046/j.1365-2141.1998.00902.x

Cited by 33 publications

(26 citation statements)

References 31 publications

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“…Furthermore, SCF significantly enhanced proliferation and invasion of KIT-positive colorectal cancer cells at concentrations exceeding 1 ng/mL. Because the level of SCF in human serum ranges between 1 ng/mL and 3 ng/mL [24,25], serum SCF can readily stimulate the proliferation and invasion of KIT-positive colorectal cancer. On the other hand, KIT and SCF co-expression has been reported and autocrine pathways were suggested in a previous work [18,19].…”

Section: Discussionmentioning

confidence: 99%

Stem Cell Factor/c-kit Receptor Signaling Enhances the Proliferation and Invasion of Colorectal Cancer Cells Through the PI3K/Akt Pathway

et al. 2007

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In this study, we examined the role of c-kit receptor (KIT) signal transduction on the proliferation and invasion of colorectal cancer cells. We found that c-kit was expressed in 2 colorectal cancer cell lines as determined by RT-PCR, Western blot, and flow cytometry. In KIT-positive lines, KIT was activated by stem cell factor (SCF). SCF enhanced cellular proliferation of positive lines as demonstrated by the WST-1 proliferation assay. Furthermore, SCF enhanced the invasive ability of KIT-positive cell lines. SCF stimulation upregulated p44/42 mitogen-activated protein kinase (MAPK) and Akt as shown by Western blot. We examined the roles played by p44/42 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways in proliferation and invasion. PI3K/Akt activity strongly correlated with proliferation and invasion and p44/42 MAPK was correlated with only invasion. In conclusion, the SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway.

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Section: Discussionmentioning

confidence: 99%

Stem Cell Factor/c-kit Receptor Signaling Enhances the Proliferation and Invasion of Colorectal Cancer Cells Through the PI3K/Akt Pathway

et al. 2007

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“…In an interesting study, serum SCF levels were significantly elevated in patients with chronic renal failure. 29 In the present study, the extent of MC infiltration tended to be higher in patients undergoing hemodialysis. An increase in serum SCF concentration in patients with endstage renal disease might stimulate MC infiltration into the interstitium.…”

Section: Discussionmentioning

confidence: 83%

Mast cells and tubulointerstitial fibrosis in patients with ANCA-associated glomerulonephritis

Otsubo

Nitta

Uchida

et al. 2003

Clinical and Experimental Nephrology

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“…Infiltrating MCs are primarily observed in the peritubular interstitial spaces especially in areas of fibrosis, some perivascular, but rarely in glomeruli. Their localization in the pathological kidney has been associated with increased systemic and interstitial levels of SCF that can be expressed by renal tubular and interstitial cells . However, few data exist concerning MCp in the kidney.…”

Section: Kidney Mast Cellsmentioning

confidence: 99%

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?

Frossi

Mion

Sibilano

et al. 2018

Immunological Reviews

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Mast cells (MCs) are derived from committed precursors that leave the hematopoietic tissue, migrate in the blood, and colonize peripheral tissues where they terminally differentiate under microenvironment stimuli. They are distributed in almost all vascularized tissues where they act both as immune effectors and housekeeping cells, contributing to tissue homeostasis. Historically, MCs were classified into 2 subtypes, according to tryptic enzymes expression. However, MCs display a striking heterogeneity that reflects a complex interplay between different microenvironmental signals delivered by various tissues, and a differentiation program that decides their identity. Moreover, tissue-specific MCs show a trained memory, which contributes to shape their function in a specific microenvironment. In this review, we summarize the current state of our understanding of MC heterogeneity that reflects their different tissue experiences. We describe the discovery of unique cell molecules that can be used to distinguish specific MC subsets in vivo, and discuss how the improved ability to recognize these subsets provided new insights into the biology of MCs. These recent advances will be helpful for the understanding of the specific role of individual MC subsets in the control of tissue homeostasis, and in the regulation of pathological conditions such as infection, autoimmunity, and cancer.

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Elevated SCF levels in the serum of patients with chronic renal failure

Cited by 33 publications

References 31 publications

Stem Cell Factor/c-kit Receptor Signaling Enhances the Proliferation and Invasion of Colorectal Cancer Cells Through the PI3K/Akt Pathway

Stem Cell Factor/c-kit Receptor Signaling Enhances the Proliferation and Invasion of Colorectal Cancer Cells Through the PI3K/Akt Pathway

Mast cells and tubulointerstitial fibrosis in patients with ANCA-associated glomerulonephritis

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?

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