Elevated Risk Profile of Women in Secondary Prevention of Coronary Artery Disease: A 6-Year Survey of 117,913 Patients

Reibis, Rona; Bestehorn, Kurt; Pittrow, David; Jannowitz, Christina; Wegscheider, Karl; Völler, Heinz

doi:10.1089/jwh.2008.1082

Cited by 21 publications

(13 citation statements)

References 47 publications

(46 reference statements)

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“…This result is in accordance with previous reports [24,25]. Singh, M., et al conducted a retrospective study [25] to analyse the gender difference of LDL-C target achievement in secondary prevention after acute myocardial infarction over a 5-year period (2003–2007).…”

Section: Discussionsupporting

confidence: 90%

Determinants for Achieving the LDL-C Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan

Yin

Chuang

et al. 2015

PLoS ONE

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BackgroundEpidemiological and clinical studies have clearly established the link between low-density lipoprotein cholesterol (LDL-C) and atherosclerosis-related cardiovascular consequences. Although it has been a common practice for physicians to prescribe lipid-lowering therapy for patients with dyslipidemia, the achievement rate is still not satisfied in Taiwan. Therefore, the determinants for achieving the LDL-C target needed to be clarified for better healthcare of the patients with dyslipidemia.MethodThis registry-type prospective observational study enrolled the patients with cardiovascular diseases (coronary artery disease (CAD) and cerebrovascular disease (CVD)) from 18 medical centers across Taiwan, and clinically followed them for five years. At every clinical visit, vital signs, clinical endpoints, adverse events, concurrent medications and laboratory specimens were obtained as thoroughly as possible. The lipid profile (total cholesterol, high-density lipoprotein cholesterol, LDL-C, triglyceride), liver enzymes, and creatinine phosphokinase were evaluated at baseline, and every year thereafter. The cross sectional observational data was analyzed for this report.ResultAmong the 3,486 registered patients, 54% had their LDL-C < 100 mg/dL. By univariate analysis, the patients achieving the LDL-C target were associated with older age, more male sex, taller height, lower blood pressure, more under lipid-lowering therapy, more smoking cessation, more history of CAD, DM, physical activity, but less history of CVD. The multivariate analysis showed statin therapy was the most significant independent determinant for achieving the treatment target, followed by age, history of CAD, diabetes, blood pressure, and sex. However, most patients were on regimens of very-low to low equipotent doses of statins.ConclusionAlthough the lipid treatment guideline adherence is improving in recent years, only 54% of the patients with cardiovascular diseases have achieved their LDL-C target in Taiwan, and the most significant determinant for this was statin therapy.

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Section: Discussionsupporting

confidence: 90%

Determinants for Achieving the LDL-C Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan

Yin

Chuang

et al. 2015

PLoS ONE

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“…Our previous studies showed that female patients had a lower medication compliance rate than that of the male . Additionally, male gender is shown to be associated with an increased goal achievement, which is consistent with previous studies that show that females are less likely to achieve goal LDL than males . The lower medication compliance rate in female patients might result in a lower goal achievement rate since medication compliance is important for the achievement of LDL‐C goal.…”

Section: Discussionsupporting

confidence: 88%

The Management of LDL Cholesterol and Predictors of Goal Achievement in Stroke Patients in China: A Cross‐Sectional Study

Wang

2016

CNS Neurosci Ther

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“…11,12 Reibis et al 11 in patients with acute coronary syndrome observed that female patients compared with males were less likely to achieve target values for blood pressure, fasting glucose, and lipid values in the early period after acute coronary events. These results are in accordance with previous reports.…”

Section: Discussionmentioning

confidence: 99%

Time Trends of Gender-Based Differences in Lipid Goal Attainments During Secondary Prevention of Coronary Artery Disease

Singh

Chin²,

Crothers

et al. 2013

American Journal of Therapeutics

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Coronary artery disease is the leading cause of death in both men and women worldwide. Little is known about gender-based differences in lipid goal attainment during secondary prevention of coronary artery disease. We conducted this study to analyze gender differences in low-density lipoprotein cholesterol target attainment in secondary prevention after acute myocardial infarction over a 5-year period. In this retrospective study, the electronic database of lipid clinic at a single center was used as the data source. Temporal trends and gender differences in demographics, lipid profile, and medication use were determined. Goal low-density lipoprotein (LDL) was defined per National Cholesterol Education Program ATP III guidelines.A total of 1365 patients (823 males, 542 females) constituted the study sample. Patients in 2007 were older than those in 2003 (females 68.6 ± 14 vs. 70.7 ± 11.7 years; males 63.6 ± 12 vs. 65.8 ± 11 years; P < 0.05) and had a higher body mass index (females 27.8 ± 1 vs. 28.6 ± 1 kg/m; males 27.6 ± 1 vs. 28.1 ± 1 kg/m, in 2003 and 2007 respectively, P < 0.05). Mean LDL decreased significantly overtime in both males and females. No gender difference in lipid-lowering therapy was observed. Females had a higher LDL than did males in 2003 (115.3 ± 12.3 vs. 99.7 ± 12.5 mg/dL; P < 0.05), and this difference persisted through 2007 (102.2 ± 11.7 vs. 91.3 ± 11.2 mg/dL; P < 0.05). Overall rate of achieving goal LDL improved from 76.5% (2003) to 83.02% (2007), P < 0.05, but remained lower for females than for males both in 2003 and 2007 [69.8% vs. 80.1% (2003), P < 0.05, and 77.9% vs. 85.6% (2007), P < 0.05].The trend over a recent 5-year period shows that females are less likely to achieve goal LDL than males are, and it indicates the need for more aggressive lipid-lowering strategies in females.

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Elevated Risk Profile of Women in Secondary Prevention of Coronary Artery Disease: A 6-Year Survey of 117,913 Patients

Abstract: Although control of cardiovascular risk factors has improved in both genders, over a recent 6-year period, female patients compared with males were less likely to achieve target values for blood pressure, fasting glucose, and lipid values in the early period after acute coronary events.

Cited by 21 publications

References 47 publications

Determinants for Achieving the LDL-C Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan

Determinants for Achieving the LDL-C Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan

The Management of LDL Cholesterol and Predictors of Goal Achievement in Stroke Patients in China: A Cross‐Sectional Study

Time Trends of Gender-Based Differences in Lipid Goal Attainments During Secondary Prevention of Coronary Artery Disease

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