Elevated Resting Heart Rate Is a Marker of Subclinical Left Ventricular Dysfunction in Hodgkin Lymphoma Survivors

Heemelaar, Julius C.; Krol, A. D.G.Stijn; Louwerens, Marloes; Beeres, Saskia L.M.A.; Holman, Eduard R.; Schalij, Martin J.; Antoni, M. Louisa

doi:10.1016/s0735-1097(21)04633-7

Cited by 2 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autonomic dysregulation is thought to be one of the most important factors. RHR reflects the balance between vagal and sympathetic systems [7], with elevated RHR indicating increased sympathetic activation and autonomic dysregulation [1,6,8]. Sympathetic nerve activation is linked not only to tumorigenesis, tumor proliferation and metastasis but also to arrhythmogenesis and cardiovascular events [1,9,10], hence, the sympathetic system might influence heart rate and tumor mortality simultaneously while on the other hand, the severity of tumors also reflects on sympathetic tone.…”

Section: Introductionmentioning

confidence: 99%

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

et al. 2022

View full text Add to dashboard Cite

Background Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer mortality in those with elevated resting heart rates (RHR). Skin sympathetic nerve activity (SKNA) is a new method of stimulating electrical signals in skin to evaluate autonomic function from sympathetic tone. In this study, we investigated the association between changes in RHR and autonomic function and ESCC mortality. Methods Thirty-nine stage II-IV ESCC patients receiving CRT between March 2019 and November 2020 were prospectively enrolled and carefully selected, followed up and received the same meticulous supportive care. Serial RHR was recorded every two weeks from before CRT to eight weeks after CRT and average SKNA were recorded before and four weeks after CRT. All-cause mortality was defined as primary outcome. Results We found the RHR of ESCC patients to be significantly elevated and peaking at four weeks after CRT (p < 0.001) and then to gradually decrease. Those with an elevated RHR above the cutoff level (18 beat-per-minute) at eight weeks after CRT had worse overall survival. In addition, those with higher baseline sympathetic tone (average SKNA ≥ 0.86 μV) also had poor outcome. Conclusions Increased pre-treatment sympathetic tone and elevated RHR after CRT are alarm signs of poor ESCC outcome. Further exploration of the mechanisms underlying these associations could potentially lead to intervention strategies for reducing mortality. Trial registration This study is registered with ClinicalTrials.gov, identifier: NCT03243448.

show abstract

Section: Introductionmentioning

confidence: 99%

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Autonomic dysregulation is thought to be one of the most important factors. RHR re ects the balance between vagal and sympathetic systems [7]. with elevated RHR indicating increased sympathetic activation and autonomic dysregulation [1,6,8].…”

Section: Introductionmentioning

confidence: 99%

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

Tang

Tsai

Lee

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer mortality in those with elevated resting heart rates (RHR). Skin sympathetic nerve activity (SKNA) is a new method of stimulating electrical signals in skin to evaluate autonomic function from sympathetic tone. In this study, we investigated the association between changes in RHR and autonomic function and ESCC mortality. Methods Thirty-nine stage II-IV ESCC patients receiving CRT between March 2019 and November 2020 were prospectively enrolled and carefully selected, followed up and received the same meticulous supportive care. Serial RHR was recorded every two weeks from before CRT to eight weeks after CRT and average SKNA were recorded before and four weeks after CRT. All-cause mortality was defined as primary outcome. Results We found the RHR of ESCC patients to be significantly elevated and peaking at four weeks after CRT (p < 0.001) and then to gradually decrease. Those with an elevated RHR above the cutoff level (18 beat-per-minute) at eight weeks after CRT had worse overall survival. In addition, those with higher baseline sympathetic tone (average SKNA ≥ 0.86µV) also had poor outcome. Conclusions Increased pre-treatment sympathetic tone and elevated RHR after CRT are alarm signs of poor ESCC outcome. Further exploration of the mechanisms underlying these associations could potentially lead to intervention strategies for reducing mortality. Trial registration: This study is registered with ClinicalTrials.gov, identifier: NCT03243448.

show abstract

Elevated Resting Heart Rate Is a Marker of Subclinical Left Ventricular Dysfunction in Hodgkin Lymphoma Survivors

Cited by 2 publications

References 50 publications

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes

Contact Info

Product

Resources

About