Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy

Abstract

Elevated local proinflammatory cytokines may be involved in the pathophysiology of pain in length-dependent small fiber neuropathy. These findings suggest a potential therapeutic role of locally applied cytokine inhibitors.

ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Increases Corneal Nerve Fiber Density

“…The etiology of the loss of small nerve fibers in sarcoidosis has not been definitively identified, but one prevalent hypothesis is that nerve fiber dropout is the end result of systemic and/or local inflammation (11). Neuropathy arising from inflammation can affect both the peripheral nerve endings and the neuronal somata within the dorsal root gan-glia of the spinal cord.…”

Pain in primary Sjögren's syndrome

“…An increased gene expression of some pro-inflammatory cytokines, such as interleukin (IL)6 and IL8, has been shown in skin biopsies of patients with SFN not related to pSS [40]. Furthermore, potentially neurotoxic autoantibodies, such as antibodies directed against RNA-binding autoantigens of the so-called GW/P bodies [41], a-fodrin [42] and type III muscarinic receptor [43], have also been reported to be associated with peripheral neurological involvement of pSS and then potentially operative even for SFN.…”

Peripheral neuropathies in Sjögren’s syndrome: A critical update on clinical features and pathogenetic mechanisms

“…Apart from their direct cytotoxic effect, T cells may exert their effects via secreted cytokines. Of interest is a recent study, involving skin biopsy specimens from patients with small fiber neuropathy of diverse etiology, which showed increased local expression of interleukin e 6 and 8, compared to healthy subjects [85]. This type of investigations using skin biopsies could prove very useful.…”