Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia

Hu, Yu; Li, Haiyan; Zhang, Lei; Shan, Baozhong; Xu, Xiao; Li, Hong; Liu, Xinguang; Xu, Shang‐Fu; Yu, Shuang; Ma, Daoxin; Peng, Jun; Hou, Ming

doi:10.1016/j.humimm.2012.04.015

Cited by 68 publications

(57 citation statements)

References 33 publications

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“…In accordance with previous reports [24,25], in our HT patients the percentage of Th17 cells positively correlated with numbers of Th22 cells. These results suggest that Th22 and Th17 subsets have a synergetic role in HT.…”

Section: Discussionsupporting

confidence: 93%

“…It was originally reported that Th22 cells were important in the pathogenesis of chronic inflammatory skin diseases [20,21]. Th22 cells have also been shown to contribute to numerous autoimmune diseases such as atopic dermatitis [22], Behcet's disease [19], systemic lupus erythematosus [23], rheumatoid arthritis [24], immune thrombocytopenia [25], systemic sclerosis [26], and others. Recently, it was reported that Th22 cells were elevated at the onset of GD [27] and in newly diagnosed HT patients [28].…”

Section: Mice and Iodine-induced Thyroiditismentioning

confidence: 99%

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Increased differentiation of Th22 cells in Hashimoto^|^rsquo;s thyroiditis

et al. 2014

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Section: Discussionsupporting

confidence: 93%

Section: Mice and Iodine-induced Thyroiditismentioning

confidence: 99%

Increased differentiation of Th22 cells in Hashimoto^|^rsquo;s thyroiditis

et al. 2014

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“…As seen in Fig. 2, RORct expression was significantly higher in active ITP patients (05.02 ± 1.03) than that in healthy controls (0.99 ± 0.22) (P < 0.01), suggesting the abnormal Th17 cells in ITP, consistent with the previously studies showing the association of Th17 differentiation with the pathogenesis of ITP [9][10][11]. However, its level was significantly lower in patients in remission (1.37 ± 0.40) than that in active patients (P < 0.01) without significant difference to controls (P > 0.05).…”

Section: Expression Of Rorct and Th17 Cells In Itp Patients And Controlssupporting

confidence: 89%

“…T helper cells (Th)1 and Th2 cells, two T cell subsets, are important for autoimmune reactivity and imbalance of Th1/Th2 has been reported to be associated with ITP [5,8]. However, in recent years, apart from Th1/Th2, another novel subset of Th cells, IL-17 secreting Th-cells (Th17) and associated cytokines (IL-17) are also identified to be implicated in the pathogenesis of ITP [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Increased RUNX1 expression in patients with immune thrombocytopenia

Liu

Zhu

et al. 2016

Human Immunology

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Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required for Th17 differentiation. Whether RUNX1 was involved in the pathogenesis of ITP remains poorly understood. In this study, 30 active ITP patients, 20 ITP in remission and 20 age and gender matched healthy controls were included. Peripheral blood mononuclear cells (PBMCs) were isolated to measure mRNA level of RUNX1 and retinoic acid receptor-related orphan receptor-γt (RORγt) by quantitative real-time PCR and Th17 cells by flow cytometry. Meanwhile, plasma was extracted for measurement of IL-17 level by ELISA. Our results showed a significantly higher expression of RUNX1, RORγt, Th17 cells and plasma level of IL-17 in active ITP patients than that in healthy controls. No differences of expression of RUNX1, RORγt and Th17 cells were observed between remission patients and controls. Furthermore, a significantly positive correlation of RUNX1 with RORγt was found in active ITP patients. In conclusion, RUNX1 was associated with the pathogenesis of ITP possibly through regulation of Th17 cell differentiation and therapeutically targeting it might be a novel approach in ITP treatment.

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“…Последние исследования показали, что при ИТП увеличивается число других подтипов Т-клеток (Th17), секретирую-щих интерлейкины 17. Интересно, что многие харак-теристики иммунной дисрегуляции, описанные при ИТП, такие как изменение баланса Th1 / Th2, повышение Th17 и изменение профилей T-клеток, отмечаются и при других аутоиммунных заболевани-ях [10][11][12][13]. Патогенетические механизмы вторичных тромбо-цитопений более сложны, чем таковые первичной ИТП.…”

Section: патогенез иммунной тромбоцитопенииunclassified