Elevated preoperative serum levels of angiogenic cytokines correlate to larger primary tumours and poorer survival in non-small cell lung cancer patients

Brattström, Daniel; Bergqvist, Michael; Hesselius, Patrik; Larsson, Anders; Lamberg, Kristina; Wernlund, Johan; Brodin, Ola; Wagenius, Gunnar

doi:10.1016/s0169-5002(02)00027-2

Cited by 61 publications

(51 citation statements)

References 32 publications

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“…When the cut-off value of serum VEGF was set at 500 pg/ml, the sensitivity in patients with SCLC was 31%. This cut-off value is the same as that used in previous reports (8,35). Recently, several tumor markers for SCLC have been reported.…”

Section: Vegf In Tumor Cells In Sclcmentioning

confidence: 99%

“…In lung cancer, several reports revealed that high serum VEGF levels are associated with greater tumor burden and prognosis in patients (8,(22)(23)(24)(25)39). Salven et al (25) reported that a high serum VEGF level is associated with a poor response to therapy and shorter survival in SCLC.…”

Section: Vegf In Tumor Cells In Sclcmentioning

confidence: 99%

“…This angiogenesis depends on several angiogenic factors (2,3,6). Some angiogenic factors play an important role in tumor progression and are an independent predictor of survival in lung cancer (7)(8)(9)(10). Vascular endothelial growth factor (VEGF) is one of the angiogenic factors (6) that is secreted by several tumor cells (11), and plays an important role in the tumor angiogenesis process (12).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, enzymelinked immunosorbent assay (ELISA) allows quantitative determination of VEGF in the serum of patients with various histologic types of cancer (17)(18)(19)(20)(21). The serum levels of VEGF in patients with lung cancer have also been reported, and high levels of VEGF in patients with SCLC are possibly associated with a poor prognosis (8,10,(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

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Vascular Endothelial Growth Factor Level as a Prognostic Determinant of Small Cell Lung Cancer in Japanese Patients

et al. 2005

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Objective To clarify the clinical significance of vascular endothelial growth factor (VEGF) in Japanese patients with small cell lung cancer (SCLC).Materials and Methods We measured serum VEGF levels using an enzyme-linked immunosorbent assay in 45 patients with SCLC before treatment and in 38 patients with benign pulmonary disease and in 32 healthy subjects (71 non-malignant subjects). VEGF immunostaining was performed in tissue biopsies obtained from 23 SCLC patients during bronchoscopic examination.Results Median serum VEGF level was 332 pg/ml in patients with SCLC and 160 pg/ml in non-malignant subjects, respectively. The 95% cut-off level to exclude nonmalignant subjects was 500 pg/ml. An elevated VEGF level (>500 pg/ml) was found more frequently in patients with extensive disease of SCLC than in those with the limited disease (p<0.01). A significant positive correlation was found between the serum VEGF level and platelet count in SCLC patients (r=0.389; p=0.0083). Serum VEGF level also correlated with serum lactate dehydrogenase in SCLC patients (r=0.381; p=0.0098). However, it did not correlate with serum neuron-specific enolase and pro-gastrin-releasing peptide level. Patients with the elevated VEGF levels had significantly shorter progressionfree time than those with the normal VEGF levels (p<0.05). Patients with the elevated VEGF levels had a significantly shorter overall survival time than those with the normal VEGF levels in univariate survival analysis (p<0.05). Further, the elevated VEGF level remained as a significant determinant of poor survival in multivariate analysis (p<0.01). Serum VEGF level was significantly higher in patients with positive VEGF protein immunoreactivity in tumor tissue in SCLC. Conclusion

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Section: Vegf In Tumor Cells In Sclcmentioning

confidence: 99%

Section: Vegf In Tumor Cells In Sclcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vascular Endothelial Growth Factor Level as a Prognostic Determinant of Small Cell Lung Cancer in Japanese Patients

et al. 2005

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“…Особенно это касается роли FGF2 [69][70][71][72][73][74]. Так, в иссле-довании, включившем данные 335 больных немелкоклеточным раком легкого, высокий уровень экспрессии FGF2 в опухолевых клет-ках был ассоциирован с низкими показателя-ми 5-летней выживаемости (37% против 59%, р=0,015).…”

Section: немелкоклеточный рак легкогоunclassified