Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity
Michael A. Portelli,
Sangita Bhaker,
Vincent Pang
et al.
Abstract:BackgroundExpression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown.ObjectivesTo determine (i) the expression profile of uPAR in cultured human bronchial epithelial cells (HBEC) from asthma patients, (ii) the relationship between uPAR and the epithelial barrier, including blocking uPAR functions and (iii) the function of different uPAR isoforms.Met… Show more
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