Elevated platelet‐associated IgG in immune thrombocytopenic purpura associated with Waldenström's macroglobulinemia

Yamamoto, Katsuya; Nagata, Kaoru; Hamaguchi, Hiroyuki

doi:10.1002/ajh.10036

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Cited by 9 publications

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“…A few case reports referred to the mechanism of immune thrombocytopenia associated with WM. Platelet-associated IgM and IgG were mentioned as possible causes [7,8]. A recent publication reported on a patient with WM where the IgM paraprotein reacted with the GPIb/IX protein on the surface membrane of platelets and inhibited GPIb-mediated platelet aggregation [9].…”

Section: Case Presentationmentioning

confidence: 99%

Agranulocytosis Associated with Waldenström Macroglobulinemia

et al. 2018

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Currently, there are only 2 case reports of Waldenström macroglobulinemia (WM) associated with severe neutropenia. This is a case report of a woman with a past medical history of WM who presented with neutropenic fever. The patient’s febrile neutropenia resolved after RCD chemotherapy (cyclophosphamide 750 mg/m², dexamethasone 20 mg, and rituximab 375 mg/m²). Fourteen days after administration, the neutrophil level had started to rise and normalized after 6 days. To the best of our knowledge, this is the 3rd reported case of agranulocytosis due to WM.

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Section: Case Presentationmentioning

confidence: 99%