Elevated platelet activation in patients with chronic urticaria: a comparison between aspirin-intolerant and aspirin-tolerant groups

Palikhe, Sailesh; Palikhe, Nami Shrestha; Kim, Seung Hyun; Yoo, Hye-Soo; Shin, Yoo Seob; Park, Hae‐Sim

doi:10.1016/j.anai.2014.06.011

Cited by 16 publications

(20 citation statements)

References 35 publications

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“…43 In addition, aspirin does not affect P-selectin expression on platelets from patients with aspirin-intolerant chronic urticaria. 44 These studies are in good agreement with the results of our study. Plasma markers do not necessarily reflect platelet activation in the airways, and further study is needed to investigate local platelet activation.…”

Section: Discussionsupporting

confidence: 95%

Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

Mitsui

Kondo

Hayashi

et al. 2016

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 95%

Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

Mitsui

Kondo

Hayashi

et al. 2016

Journal of Allergy and Clinical Immunology

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“…More difficult to explain is lower PLR in NECD than in other types of NSAID hypersensitivity. The absolute number and percentage of platelets and lymphocytes were comparable among all types of NSAID hypersensitivity [24,25]. In our study, most patients with NECD also had chronic spontaneous urticaria, which was asymptomatic at the time of the study.…”

Section: Discussionsupporting

confidence: 56%

Eosinophil/Neutrophil/Platelet-to-Lymphocyte Ratios in Various Types of Immediate Hypersensitivity to NSAIDs: A Preliminary Study

Branicka

Rogala

Glück

2020

Int Arch Allergy Immunol

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Background: The eosinophil/neutrophil/platelet-to-lymphocyte ratios (ELR, NLR, and PLR) have been used as clinical markers of systemic inflammation. However, they have not yet been tested in various subtypes of immediate hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs). Objectives: To assess the ELR, NLR, and PLR in various types of hypersensitivity to NSAIDs. Materials and Methods: A retrospective analysis of complete blood cell count and the ELR, NLR, and PLR was performed. Appropriate types of hypersensitivity to NSAIDs were diagnosed based on the anamnesis and drug provocation tests. The analysis covered 97 patients. Twenty were diagnosed with NERD (NSAID-exacerbated respiratory disease), 20 with NECD (NSAID-exacerbated cutaneous disease), 38 with NIUA (NSAID-inducted urticaria/angioedema), and 19 with SNIUAA (single-NSAID-induced urticaria/angioedema or anaphylaxis). Two controls groups were included: the first covered 15 patients with bronchial asthma and the second 28 patients with chronic spontaneous urti-caria without NSAID hypersensitivity. Results: The NLR did not differ significantly between the NSAID hypersensitivity types. The ELR was significantly higher in NERD patients, and the PLR was significantly lower in NECD patients than in patients with other types of NSAID hypersensitivity and in controls. Conclusions: The ELR and PLR may be useful in differentiating various types of immediate hypersensitivity to NSAIDs. Moreover, the ELR may be helpful in differentiating patients with bronchial asthma with and without NSAID hypersensitivity and PLR in differentiating patients with chronic spontaneous urticaria from NECD.

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“…To what extent platelets are involved in the pathogenesis of NECD remains to be established. 27,28 Diagnosis The diagnosis of NECD first requires confirmation of the diagnosis of chronic urticaria, which by definition is the spontaneous development of urticaria that has been continuously or intermittently present for at least 6 weeks. 29 A careful history can confirm the diagnosis of NECD if the patient has previously reacted to NSAIDs or acetylsalicylic acid (ASA) with exacerbation of their underlying chronic urticaria.…”

Section: Clinical Presentationmentioning

confidence: 99%

Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema

Kowalski

Woessner

Sanak

2015

Journal of Allergy and Clinical Immunology

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Nonsteroidal anti-inflammatory drug (NSAID)-induced urticarial and angioedema reactions are among the most commonly encountered drug hypersensitivity reactions in clinical practice. Three major clinical phenotypes of NSAID-induced acute skin reactions manifesting with angioedema, urticaria, or both have been distinguished: NSAID-exacerbated cutaneous disease, nonsteroidal anti-inflammatory drug-induced urticaria/angioedema (NIUA), and single NSAID-induced urticaria and angioedema. In some patients clinical history alone might be sufficient to establish the diagnosis of a specific type of NSAID hypersensitivity, whereas in other cases oral provocation challenges are necessary to confirm the diagnosis. Moreover, classification of the type of cutaneous reaction is critical for proper management. For example, in patients with single NSAID-induced reactions, chemically nonrelated COX-1 inhibitors can be safely used. However, there is cross-reactivity between the NSAIDs in patients with NSAID-exacerbated cutaneous disease and NIUA, and thus only use of selective COX-2 inhibitors can replace the culprit drug if the chronic treatment is necessary, although aspirin desensitization will allow for chronic treatment with NSAIDs in some patients with NIUA. In this review we present a practical clinical approach to the patient with NSAID-induced urticaria and angioedema.

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Elevated platelet activation in patients with chronic urticaria: a comparison between aspirin-intolerant and aspirin-tolerant groups

Cited by 16 publications

References 35 publications

Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

Eosinophil/Neutrophil/Platelet-to-Lymphocyte Ratios in Various Types of Immediate Hypersensitivity to NSAIDs: A Preliminary Study

Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug–related urticaria and angioedema

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