Elevated plasma TGF-β1 levels in patients with chronic obstructive pulmonary disease

Mak, Judith C.W.; Chan‐Yeung, Moira; Ho, Stanley; Chan, K. S.; Choo, Kahlin; Yee, Kwok Sang; Chau, CH; Cheung, Amy; Ip, Mary S.M.

doi:10.1016/j.rmed.2009.01.005

Cited by 69 publications

(51 citation statements)

References 36 publications

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“…As described previously, TGF-β1 is elevated in serum from COPD patients [53], which could lead to increased numbers of Th17 cells. Serum and sputum levels of IL-6 are increased during periods of exacerbations in COPD [84], again potentially leading to increased numbers of Th17 cells.…”

Section: Control Of Differentiationmentioning

confidence: 60%

“…IL-2-deficient mice have a reduced number of nT reg -cells, indicating the importance in T regcell proliferation [52]. Increased levels of TGF-β1 in serum in patients with COPD compared with healthy controls has been found [53]. In addition, IL-2 levels are higher in patients with stable COPD [54] compared with those who exhibit a rapid decline in lung function.…”

Section: Control Of Differentiationmentioning

confidence: 99%

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Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

et al. 2010

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COPD (chronic obstructive pulmonary disease) is an inflammatory disorder of the airways, which is associated with irreversible airway obstruction. The pathological hallmarks of COPD are destruction of the lung parenchyma (pulmonary emphysema), inflammation of the central airways (chronic bronchitis) and inflammation of the peripheral airways (respiratory bronchiolitis). Tobacco smoking is established as the main aetiological factor for COPD. A maladaptive modulation of inflammatory responses to inhalation of noxious particles and gases is generally accepted as being a key central pathogenic process; however, the precise regulatory mechanisms of the disease are poorly understood. Two cell types are known to be important in immune regulation, namely regulatory T-cells and the newly identified Th17 (T-helper 17) cells. Both types of cells are subsets of CD4 T-lymphocytes and modulate the immune response through secretion of cytokines, for example IL (interleukin)-10 and IL-17 respectively. The present review will begin by describing the current understanding of inflammatory cell involvement in the disease process, and then focus on the possible role of subsets of regulatory and helper T-cells in COPD.

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Section: Control Of Differentiationmentioning

confidence: 60%

Section: Control Of Differentiationmentioning

confidence: 99%

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

et al. 2010

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“…It has reported TGF-β1 elevated in the plasma of COPD patients 23,24) and increased the release of active TGF-β1 induced by cigarette smoke in rat tracheal explant. 25) We found in this study that enhanced TGF-β1 expression correlated with the increase in airway wall thickness and collagen deposition and that the elevation of TGF-β1 in the mRNA and protein level was significantly inhibited in COPD rats after HSYA treatment.…”

Section: Disscusionmentioning

confidence: 99%

Hydroxysafflor Yellow A Attenuates Small Airway Remodeling in a Rat Model of Chronic Obstructive Pulmonary Disease

Wang

Xue

Dong

et al. 2014

Biological & Pharmaceutical Bulletin

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Our previous studies found that hydroxysafflor yellow A (HSYA), an active ingredient in Carthamus tinctorius L., has anti-inflammatory and anti-fibrosis properties. In this study, we investigated the effect of HSYA on small airway remodeling (SAR) in a chronic obstructive pulmonary disease (COPD) rat model induced by cigarette smoke and lipopolysaccharide (LPS). SAR is a common lesion in COPD characterized by thickening of the airway wall, mainly by subepithelial fibrosis. In this study the thickness of the small airway was determined by total wall area/basement membrane perimeter (WAt/Pbm). Collagen deposition of the small airway was assessed by Masson's trichrome staining. HSYA significantly attenuated the thickening and collagen deposition of the small airway and inhibited transforming growth factor β1 (TGF-β1) mRNA and protein expression in COPD rat. In addition, HSYA inhibited the phosphorylation of p38 mitogen-activated protein kinases (MAPK) in the lung tissue of rat. HSYA can attenuate experimentally induced airway remodeling and this attenuation may be attributed to suppression of TGF-β1 expression.Key words hydroxysafflor yellow A; airway remodeling; transforming growth factor-β1; p38 mitogen-activated protein kinase (MAPK); chronic obstructive pulmonary disease (COPD)Chronic obstructive pulmonary disease (COPD), characterized by airflow limitation that is progressive and persistent, is a leading cause of death worldwide.1) Cigarette smoking and bacterial infection have been widely recognized as the main causes of COPD.2,3) The main pathological changes of the lung from COPD are emphysema and small airway remodeling (SAR).4) SAR, characterized by subepithelial fibrosis, goblet cell metaplasia and excessive mucus production, is now accepted as an important cause of airflow obstruction in COPD.5) No ideal medication has been able to effectively reverse the airway remodeling. Therefore the development of novel medications for the prevention of airway remodeling in COPD is urgently needed.More recently, the role of transforming growth factor β1 (TGF-β1) in the pathogenesis of SAR in COPD has attracted more interests, particularly since genetic studies have demonstrated gene polymorphisms of the TGF-β superfamily is associated with COPD. TGF-β1 is ubiquitously expressed and is secreted by many lung cell types including airway epithelial cells, vascular endothelial cells, smooth muscle cells, fibroblasts and inflammatory cells. 6)TGF-β1 can increase deposition of extracellular matrix in the airways and can stimulate lung fibroblast differentiating into myofibroblast.7) It has been reported that intratracheal instillation of TGF-β1 in mice leads to airway remodeling with peribronchiolar collagen deposition and basal membrane thickening. 8) Thus, it seems reasonable to hypothesize that targeting the TGF-β1 expression may provide a novel therapeutic method for attenuating SAR in COPD.Safflower is the dry flower of Carthamus tinctorius L. and naturally distributed around the world.9) It has been used extensively...

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“…A genome-wide linkage analysis in the Boston Early-Onset COPD study suggested that SERPINE2 may be associated with the COPD-related phenotypes (Palmer et al, 2003;Silverman et al, 2002). Similarly, the association analysis of the family-based data showed significant association of multiple SERPINE2 single nucleotide polymorphisms (SNPs) with COPD related-phenotypes, which was confirmed by Mak et al, 2009;Su et al, 2005) than in European (van Diemen et al, 2010;Wu et al, 2004). Given the large differences in genetic background of Asians and Europeans (Li et al, 2008;Zhao and Lee, 1989), it is important to provide further evidences related to these distinct populations to detect the complexity of COPD.…”

Section: Introductionmentioning

confidence: 84%

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

Hua

et al. 2012

Genes Genet. Syst.

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Chronic Obstructive Pulmonary Disease (COPD) is a complex human disease which is driven not only by genetic factors, but also by various environmental variables, such as gender, age and smoking. Therefore, there is a demand for investigating the complexity among various risk factors involved in COPD. In this study, 44 tagging SNPs from EPHX1, GSTP1, SERPINE2 and TGFB1 were selected and genotyped in 310 COPD cases and 203 controls, all of which belong to the Han from North China. We integrated functional prediction algorithms of nonsynonymous SNPs (nsSNPs) into Bayesian network to explore the complex regulatory relationships among disease traits and various risk factors. The results showed that three basic variables (age, sex and smoking) were risk factors of COPD-related trait and phenotype. Besides these environmental risk factors, deleterious nsSNPs were found to perform better than those of significant synonymous SNPs when used as variables to make risk prediction of disease outcome. This study provides further evidences for detecting the complexity of COPD in Northern Chinese Han Population.

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Elevated plasma TGF-β1 levels in patients with chronic obstructive pulmonary disease

Cited by 69 publications

References 36 publications

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells

Hydroxysafflor Yellow A Attenuates Small Airway Remodeling in a Rat Model of Chronic Obstructive Pulmonary Disease

A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population

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