Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms

Wu, Zixiang; Zhang, Xiang Yang; Wang, Huanhuan; Tang, Wei; Yu, Xiang; Zhang, FeiXue; Liu, Jiahong; Fu, Ye; Hu, Jianjun; Chen, Yuanling; Liu, Linjing; Chen, Da Chun; Xiu, Mei Hong; Kosten, Thomas R.; He, Jincai

doi:10.1016/j.pnpbp.2011.08.018

Cited by 51 publications

(35 citation statements)

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“…Although the this confirms some studies [57,58], it also contradicts others that found no difference in SOD activity between chronic SCZ patients and healthy controls [59] or found increased SOD activity in FEP and chronic SCZ patients compared to normal controls [60]. As in the latter study, the levels of SOD were greater in FEP than in chronic patients, the authors suggested that OS might occur in the initial phase of SCZ, getting worse with the chronicity of the disorder.…”

Section: Oxidative Stress-a Field For New Tailored Therapies?supporting

confidence: 66%

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Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

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Section: Oxidative Stress-a Field For New Tailored Therapies?supporting

confidence: 66%

“…As in the latter study, the levels of SOD were greater in FEP than in chronic patients, the authors suggested that OS might occur in the initial phase of SCZ, getting worse with the chronicity of the disorder. This could either be explained by aging or by antipsychotic treatment [60].…”

Section: Oxidative Stress-a Field For New Tailored Therapies?mentioning

confidence: 99%

Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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“…The GPx level was reported to be higher in a study of patients with first-episode schizophrenia [32], while another study reported lower GPx levels [29]. The SOD level [33] was reported to be lower in one study conducted in patients with treated and untreated schizophrenia, while another study reported higher SOD levels [34]. …”

Section: Discussionmentioning

confidence: 99%

“…A study on patients with treated and untreated schizophrenia reported a negative correlation between total GSH (GSHt) and reduced GSH (GSHr) levels and the CGI score [33]. Plasma SOD activity was found to be negatively correlated with positive symptoms in both treated and untreated patients with schizophrenia; however, no such relationship was found in patients with FEP [34]. …”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

Şimşek

Gençoğlan

Yüksel³

et al. 2016

Neuropsychobiology

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Objective: Oxidative stress has been reported to play a role in the psychopathology of schizophrenia, though only a few studies have investigated the relationship between early-onset schizophrenia and oxidative stress. The aim of the present study is to evaluate the level of oxidative stress and the presence of DNA damage in first-episode psychosis (FEP) in adolescents. Methods: This study was conducted in the Department of Child Psychiatry of the Dicle University Hospital. It included 20 adolescent patients (age 11-17 years) with psychosis (acute psychosis, schizophreniform disorder, or schizophrenia) according to DSM-IV criteria who had received no previous psychiatric therapy (patient group) and 20 age/gender-matched healthy adolescents (control group). Structured psychiatric interviews [Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version (K-SADS-PL) and Positive and Negative Symptom Scale (PANSS)] were conducted on the patients, and the Clinical Global Impressions (CGI) scale was used to evaluate the severity of disease. Glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q (CoQ), and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were determined using the ELISA method and commercial ELISA kits. Results: The mean age was 14.5 ± 1.6 years in the FEP group (male-to-female ratio: 8/12) and 14.4 ± 1.5 years in the control group (male-to-female ratio: 8/12). There were no differences between the patient and control groups in terms of SOD, GPx, or 8-OHdG values (p > 0.05). Conclusions: This study on DNA damage and oxidative stress in FEP in adolescents had a small sample size, and our data suggest that oxidative stress is associated with a chronic disease course rather than being an early sign of early-onset schizophrenia.

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“…Levels vary among schizophrenia subtypes. Studies that divide experimental patients into three subtypes: paranoid type; residual type; and disorganized type, Herken, et al [9] did find that erythrocyte CAT level of the three subtypes was significantly higher than that of the normal control group. However erythrocyte SOD levels were not significantly different.…”

Section: Changes Of Antioxidant System In Schizophreniamentioning

confidence: 99%

Oxidative Stress and Schizophrenia

2017

J Psychiatry Brain Sci.

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Many studies show that oxidative stress is a pathophysiological mechanism of schizophrenia. Elevated oxidative stress levels and the damage to the antioxidant defense system can observed in early schizophrenia. High oxidation levels damage lipids, proteins, nucleic acids and other tissues. Antioxidant defense system imbalance has been observed in both neuroleptic-naïve first-episode schizophrenics and chronic schizophrenics being treated with medication and indicates the presence of oxidative stress in schizophrenia.Antipsychotic drugs also exert certain impacts on oxidative stress while improving the schizophrenia clinical symptoms. Antioxidants synergistically improve schizophrenia clinical symptoms. A combination regime of antipsychotic drugs and antioxidants is a potentially effective treatment strategy for schizophrenia.Keywords: Schizophrenia; Oxidative stress; Antioxidant defense system; Antioxidants.Schizophrenia is a common, serious mental illness, usually associated with, among other things, disordered perceptions, thoughts, emotions, volition and behavior. Major symptoms include positive symptoms (e.g. delusions or hallucinations), negative symptoms (i.e. affective flattening, alogia, or avolition) and cognitive dysfunction. The precise etiology of the disease remain unclear and both genetic and environmental factors appear to be involved. Recently scholars and researchers have begun to study the effect of oxidative stress on schizophrenia pathophysiology and it is thought to be involved in schizophrenia generation and development. This study reviews, and summarizes, schizophrenia pathogenesis, and oxidative stress medication therapy. Oxidative stress explained first, followed by a discussion of its relationship to schizophrenia. It then discusses http://jpbs.qingres.com

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Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms

Cited by 51 publications

References 49 publications

Biomarkers and schizophrenia: a qualitative review

Biomarkers and schizophrenia: a qualitative review

Oxidative Stress and DNA Damage in Untreated First-Episode Psychosis in Adolescents

Oxidative Stress and Schizophrenia

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