Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019

Wada, Hideo; Ichikawa, Yuhuko; Ezaki, Minoru; Yamamoto, Akira; Tomida, Masaki; Yoshida, Masamichi; Fukui, Shunsuke; Moritani, Isao; Shiraki, Katsuya; Shimaoka, Motomu; Iba, Toshiaki; Suzuki‐Inoue, Katsue; Shimpo, Hideto

doi:10.3390/jcm11040985

Cited by 15 publications

(28 citation statements)

References 32 publications

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“…1, at the time of massive bleeding, was intubated, and sedation and mechanical ventilation were initiated. Wada et al [ 14 ], as a result of the conducted research, stated that platelet activation may be important in the worsening progress of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Bleeding into the Abdominal and Ilio-Lumbar Muscles—A Rare Complication in the Course of COVID-19: Analysis of Four Cases and a Literature Review

Mackiewicz−Milewska

Sakwińska

Cisowska-Adamiak

et al. 2022

JCM

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The risk of venous thromboembolic (VTE) complications, mainly in the form of pulmonary embolism (PE) and deep vein thrombosis (DVT), in COVID-19 is well known, necessitating the administration of thrombotic prophylaxis in most patients. With a high risk of VTE complications or their presence, full anticoagulation may be associated with hemorrhagic complications. COVID-19 bleeding is rarely reported. Here, we present four cases of patients with muscle bleeding: two in the iliopsoas muscle, which resulted in death despite the embolization of the bleeding vessel, and two in the oblique and straight abdominal muscles, which were treated conservatively. In the reported cases, the severity of the bleeding coincided with the severity of the course of COVID-19. When observing a sudden drop in hemoglobin (Hb) in a patient with COVID-19, one must always remember the possible complications in the form of muscle bleeding, which can be fatal.

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Section: Discussionmentioning

confidence: 99%

Bleeding into the Abdominal and Ilio-Lumbar Muscles—A Rare Complication in the Course of COVID-19: Analysis of Four Cases and a Literature Review

Mackiewicz−Milewska

Sakwińska

Cisowska-Adamiak

et al. 2022

JCM

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“…50 The elevated plasma levels of soluble CLEC-2 have been reported in patients with thrombotic microangiopathy and DIC, 51 52 as well as in patients with arterial thrombosis such as acute coronary syndrome 53 and acute cerebral infarction. 54 Wada et al 55 reported that the plasma levels of CLEC-2 in COVID-19 patients were significantly higher than in those with bacterial infections, and the levels reflected the severity of illness. Notably, the platelet counts were maintained within the normal range in those patients.…”

Section: Platelet-related Biomarkersmentioning

confidence: 99%

Platelet Activation and Thrombosis in COVID-19

Iba

Wada

Levy

2022

Semin Thromb Hemost

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Although thrombosis frequently occurs in infectious diseases, the coagulopathy associated with COVID-19 has unique characteristics. Compared with bacterial sepsis, COVID-19-associated coagulopathy presents with minimal changes in platelet counts, normal prothrombin times, and increased D-dimer and fibrinogen levels. These differences can be explained by the distinct pathophysiology of the thromboinflammatory responses. In sepsis-induced coagulopathy, leukocytes are primarily responsible for the coagulopathy by expressing tissue factor, releasing neutrophil extracellular traps, multiple procoagulant substances, and systemic endothelial injury that is often associated with vasoplegia and shock. In COVID-19-associated coagulopathy, platelet activation is a major driver of inflammation/thrombogenesis and von Willebrand factor and platelet factor 4 are deeply involved in the pathogenesis. Although the initial responses are localized to the lung, they can spread systemically if the disease is severe. Since the platelets play major roles, arterial thrombosis is not uncommon in COVID-19. Despite platelet activation, platelet count is usually normal at presentation, but sensitive biomarkers including von Willebrand factor activity, soluble P-selectin, and soluble C-type lectin-like receptor-2 are elevated, and they increase as the disease progresses. Although the role of antiplatelet therapy is still unproven, current studies are ongoing to determine its potential effects.

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“…A second approach, used by Wada and collaborators, 8 is based on surrogate markers, that is, on the detection in plasma of molecules that could be released from activated platelets, with the idea that the higher the concentration of molecules released from platelets, the greater the extent of platelet activation. In their study, Wada and collaborators make a case for the role of C‐type lectin‐like receptor 2 (CLEC‐2).…”

Section: Figurementioning

confidence: 99%

“Unconventional CD147‐dependent platelet activation elicited by SARS‐CoV‐2 in COVID‐19”: Reply

Maugeri

Manfredi

2022

Journal of Thrombosis and Haemostasis

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Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019

Cited by 15 publications

References 32 publications

Bleeding into the Abdominal and Ilio-Lumbar Muscles—A Rare Complication in the Course of COVID-19: Analysis of Four Cases and a Literature Review

Bleeding into the Abdominal and Ilio-Lumbar Muscles—A Rare Complication in the Course of COVID-19: Analysis of Four Cases and a Literature Review

Platelet Activation and Thrombosis in COVID-19

“Unconventional CD147‐dependent platelet activation elicited by SARS‐CoV‐2 in COVID‐19”: Reply

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